The application of the hierarchical approach for the construction of foldameric peptide self-assembled nanostructures

Abstract

In this paper, we show that a hierarchical approach for the construction of nanofibrils based on α,β-peptide foldamers is a rational method for the design of novel self-assembled nanomaterials based...

Scalable Synthesis of All Stereoisomers of 2-Aminocyclopentanecarboxylic Acid─A Toolbox for Peptide Foldamer Chemistry

“…Peptide foldamers incorporating β-amino acids, such as ACPC, have shown numerous unique properties and activities. , Excellent biological activities ranging from anticancer, antibacterial, and antiviral to antifungal activities, combined with high resistance to proteolytic degradation, make members of this class of compounds valuable drug candidates. − Moreover, there are peptide foldamers with interesting catalytic activity. − Another interesting property of this class of compounds is the possibility of the formation of nanostructures. , …”

“…22−25 Another interesting property of this class of compounds is the possibility of the formation of nanostructures. 26,27 Considering all of the achievements mentioned above, it could be stated without doubt that molecules with wellpredictable three-dimensional structures and chosen functions can be constructed using constrained β-amino acid building blocks. However, the major technical problem with the wide application of this technology is access to appropriate amounts of enantiomerically pure derivatives of constrained β-amino acids useful for solid-phase peptide synthesis, in particular, ACPC.…”

“… 22 − 25 Another interesting property of this class of compounds is the possibility of the formation of nanostructures. 26 , 27 …”