The application of the Fischer indole synthesis in medicinal chemistry

α-Hydroxydimethylacetal/ketal as an α-hydroxycarbonyl equivalent in interrupted Heyns/Amadori rearrangement: regioselective synthesis of substituted C2- and C3-acylindoles

“…Because of their high importance, the synthesis of these functionalized indoles has been an important topic of interest to chemists and methodological developments towards their effective synthesis continue to emerge. 9 Although traditionally indole scaffolds have been achieved through Fisher indole synthesis 10 and cyclization of 2-alkynylanilines, 11 metal catalyzed synthesis of indole 12 has been a strategy of choice in contemporary organic synthesis. Despite the developments in the synthesis of indole scaffolds, methods known for the construction of 2- or 3-acylindole are scarce.…”