The Application of Surface Response Methodology to the Pretreatment of WC Substrates Prior to Diamond Coating

Shirdar, Mostafa Rezazadeh; Golshan, Abolfazl; Izman, S.; Ghodsiyeh, Danial

doi:10.1007/s11665-013-0691-z

Cited by 12 publications

(1 citation statement)

References 15 publications

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“…Response surface methodology (RSM) is defined as a collection of the statistical and mathematical techniques that can be employed to determine the effect of several factors at different levels and further their effects on each other [ 35 ]. This technique is suitable for analyzing and modeling for a specific application where a response of interest is influenced by different variables [ 36 , 37 ].…”

Section: Methodsmentioning

confidence: 99%

Optimization of the Mechanical Properties and the Cytocompatibility for the PMMA Nanocomposites Reinforced with the Hydroxyapatite Nanofibers and the Magnesium Phosphate Nanosheets

Shirdar

Taheri

et al. 2021

Materials

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Commercial poly methyl methacrylate (PMMA)-based cement is currently used in the field of orthopedics. However, it suffers from lack of bioactivity, mechanical weakness, and monomer toxicity. In this study, a PMMA-based cement nanocomposite reinforced with hydroxyapatite (HA) nanofibers and two-dimensional (2D) magnesium phosphate MgP nanosheets was synthesized and optimized in terms of mechanical property and cytocompatibility. The HA nanofibers and the MgP nanosheets were synthesized using a hydrothermal homogeneous precipitation method and tuning the crystallization of the sodium-magnesium-phosphate ternary system, respectively. Compressive strength and MTT assay tests were conducted to evaluate the mechanical property and the cytocompatibility of the PMMA-HA-MgP nanocomposites prepared at different ratios of HA and MgP. To optimize the developed nanocomposites, the standard response surface methodology (RSM) design known as the central composite design (CCD) was employed. Two regression models generated by CCD were analyzed and compared with the experimental results, and good agreement was observed. Statistical analysis revealed the significance of both factors, namely, the HA nanofibers and the MgP nanosheets, in improving the compressive strength and cell viability of the PMMA-MgP-HA nanocomposite. Finally, it was demonstrated that the HA nanofibers of 7.5% wt and the MgP nanosheets of 6.12% wt result in the PMMA-HA-MgP nanocomposite with the optimum compressive strength and cell viability.

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Section: Methodsmentioning

confidence: 99%