The Application of Small Molecules to the Control of Typical Species Associated With Oral Infectious Diseases

Shen, Yang; Lyu, Xiaoying; Zhang, Jin; Shui, Yusen; Yang, Ran; Xu, Xin

doi:10.3389/fcimb.2022.816386

Cited by 4 publications

(3 citation statements)

References 167 publications

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“…In the oral cavity, wound healing is not just limited to recovering from injury or surgery, but it also covers the biological processes that occur after diseases including cancer and infections [ 2 ]. Various strategies have been employed to promote oral tissue repair [ 34 ]. However, the adopted strategies, including non-surgical or surgical modalities combined with antimicrobial therapies, have not always achieved the wished success.…”

Section: Discussionmentioning

confidence: 99%

Emerging Effects of Resveratrol Derivatives in Cells Involved in Oral Wound Healing: A Preliminary Study

D’Amico

Pierfelice

Amoroso

et al. 2023

IJMS

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Recently, there has been an increasing interest in finding new approaches to manage oral wound healing. Although resveratrol (RSV) exhibited many biological properties, such as antioxidant and anti-inflammatory activities, its use as a drug is limited by unfavorable bioavailability. This study aimed to investigate a series of RSV derivatives (1a–j) with better pharmacokinetic profiles. At first, their cytocompatibility at different concentrations was tested on gingival fibroblasts (HGFs). Among them, derivatives 1d and 1h significantly increased cell viability compared to the reference compound RSV. Thus, 1d and 1h were investigated for cytotoxicity, proliferation, and gene expression in HGFs, endothelial cells (HUVECs), and oral osteoblasts (HOBs), which are the main cells involved in oral wound healing. For HUVECs and HGFs, the morphology was also evaluated, while for HOBs ALP and mineralization were observed. The results showed that both 1d and 1h did not exert negative effects on cell viability, and at a lower concentration (5 µM) both even significantly enhanced the proliferative rate, compared to RSV. The morphology observations pointed out that the density of HUVECs and HGFs was promoted by 1d and 1h (5 µM) and mineralization was promoted in HOBs. Moreover, 1d and 1h (5 µM) induced a higher eNOS mRNA level in HUVECs, higher COL1 mRNA in HGFs, and higher OCN in HOBs, compared to RSV. The appreciable physicochemical properties and good enzymatic and chemical stability of 1d and 1h, along with their promising biological properties, provide the scientific basis for further studies leading to the development of RSV-based agents useful in oral tissue repair.

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Section: Discussionmentioning

confidence: 99%

Emerging Effects of Resveratrol Derivatives in Cells Involved in Oral Wound Healing: A Preliminary Study

D’Amico

Pierfelice

Amoroso

et al. 2023

IJMS

View full text Add to dashboard Cite

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“…Several studies have found that caffeic acid can inhibit the growth of oral pathogens, such as Streptococcus mutans and Porphyromonas gingivalis, which are associated with dental caries and periodontitis, respectively. Caffeic acid works by disrupting the bacterial cell membrane and inhibiting the activity of enzymes involved in bacterial metabolism [34].…”

Section: Discussionmentioning

confidence: 99%

Antibacterial Activity of Lysimachia nummularia L. in Oro-Dental Diseases

et al. 2023

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The aim is to evaluate the antibacterial and antifungal properties of the extracts obtained from Lysimachia nummularia L. in order to be able to introduce these extracts into pharmaceutical products and obtain useful products in the infectious and antifungal pathology of the oro-dental cavity. Extracts from different parts of the studied species have been obtained and chemically characterized: the total polyphenols in 40% ethanolic extracts have been determined and the caffeic and chlorogenic acids and trans-resveratrol, bioactive compounds involved in the antimicrobial properties of the studied species, have been identified, separated, and quantitatively determined. The antibacterial and antifungal activities of the extract of Lisymachia nummularia L. were determined using the diffusion method against a set of bacteria isolated from samples from different patients with diseases of the oro-dental cavity. The extract of Lisymachia nummularia L. exhibited antimicrobial activity against Gram-positive bacteria more than Gram-negative, where the effect was weaker; however, it had no antifungal effects on Candida albicans. Another aspect that must be emphasized is that the best antibacterial results were obtained from the aerial segment of the plant, the part where the highest concentration of polyphenols was identified in the studies presented. These results indicate that the pharmacological effects of the studied bacterial species support the use of extracts in obtaining pharmaceutical products that can be used to optimize treatment schemes in oro-dental diseases.

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“…Dental biofilm is composed of a wide variety of microorganisms; microbial dysbiosis in this biofilm contributes to the occurrence of both caries and periodontal diseases [ 9 , 10 ]. Based on epidemiological and experimental studies, oral health care providers recommend that effective oral hygiene, through the mechanical removal of the biofilm, be conducted to maintain optimal oral health [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Socioeconomic Inequalities and Toothbrushing Frequency among Schoolchildren Aged 6 to 12 Years in a Multi-Site Study of Mexican Cities: A Cross-Sectional Study

et al. 2022

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Periodic toothbrushing is the most common, effective, and reliable way to mechanically remove biofilm from oral tissues. The objective of the present study was to determine the association between toothbrushing frequency and socioeconomic position for schoolchildren between 6 and 12 years of age in four cities in Mexico. A cross-sectional study was conducted on 500 Mexican schoolchildren between 6 and 12 years of age from public schools in four Mexican cities. Questionnaires were administered to the parents/guardians of the schoolchildren to obtain the variables included in the study. The dependent variable was toothbrushing frequency, dichotomized as: 0 = less than twice a day and 1 = at least twice a day. The analysis was performed in Stata. The average age of the schoolchildren was 8.9 ± 1.9 years; 50.4% were female. The prevalence of toothbrushing was 52.8% (at least twice a day) (95% CI = 48.4−57.1). In the multivariate model, the variables associated (p < 0.05) with toothbrushing frequency were older age of the schoolchild (OR = 1.14); younger age of the mother (OR = 0.93); being a girl (OR = 1.70); being enrolled in Seguro Popular (OR = 0.69); being in a household that was owned (OR = 2.43); and being a schoolchild who lived in a home that owned a car (OR = 1.31). The prevalence of toothbrushing at least twice a day was just over 50% in these Mexican children. We found demographic and socioeconomic variables to be associated with toothbrushing. Based on socioeconomic variables that were associated with toothbrushing frequency—such as health insurance, home ownership and the household owning a car—the results of the present study confirm the existence of health inequalities in toothbrushing frequency.

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The Application of Small Molecules to the Control of Typical Species Associated With Oral Infectious Diseases

Cited by 4 publications

References 167 publications

Emerging Effects of Resveratrol Derivatives in Cells Involved in Oral Wound Healing: A Preliminary Study

Emerging Effects of Resveratrol Derivatives in Cells Involved in Oral Wound Healing: A Preliminary Study

Antibacterial Activity of Lysimachia nummularia L. in Oro-Dental Diseases

Socioeconomic Inequalities and Toothbrushing Frequency among Schoolchildren Aged 6 to 12 Years in a Multi-Site Study of Mexican Cities: A Cross-Sectional Study

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