The application of probiotics and flaxseed promotes metabolism of n-3 polyunsaturated fatty acids in pigs

Sopková, Drahomíra; Hertelyová, Zdenka; Andrejčáková, Zuzana; Vlčková, Radoslava; Gancarčíková, Soňa; Petrílla, Vladimir; Ondrašovičová, Silvia; Krešáková, Lenka

doi:10.1080/09712119.2015.1124333

Cited by 24 publications

(18 citation statements)

References 37 publications

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“…In chicken farming, efforts seeking alternatives for in-feed antibiotics started in the 1980s and have gained enormous interest in recent years [ 11 ]. Such alternatives include fiber-degrading enzymes, prebiotics, probiotics, symbiotics, and phytobiotics [ 12 ]. Among them, probiotics are advantageous for its low production cost and wide range of application among different kinds of host animals [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Feed-additive probiotics accelerate yet antibiotics delay intestinal microbiota maturation in broiler chicken

et al. 2017

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Background: Reducing antibiotics overuse in animal agriculture is one key in combat against the spread of antibiotic resistance. Probiotics are a potential replacement of antibiotics in animal feed; however, it is not clear whether and how probiotics and antibiotics differ in impact on physiology and microbial ecology of host animals. Results: Host phenotype and fecal microbiota of broilers with either antibiotics or probiotics as feed additive were simultaneously sampled at four time points from birth to slaughter and then compared. Probiotic feeding resulted in a lower feed conversion ratio (FCR) and induced the highest level of immunity response, suggesting greater economic benefits in broiler farming. Probiotic use but not antibiotic use recapitulated the characteristics of age-dependent development of gut microbiota in the control group. The maturation of intestinal microbiota was greatly accelerated by probiotic feeding, yet significantly retarded and eventually delayed by antibiotic feeding. LP-8 stimulated the growth of many intestinal Lactobacillus spp. and led to an altered bacterial correlation network where Lactobacillus spp. are negatively correlated with 14 genera and positively linked with none, yet from the start antibiotic feeding featured a less-organized network where such inter-genera interactions were fewer and weaker. Consistently, microbiota-encoded functions as revealed by metagenome sequencing were highly distinct between the two groups. Thus, "intestinal microbiota maturation index" was proposed to quantitatively compare impact of feed additives on animal microecology. Conclusions: Our results reveal a tremendous potential of probiotics as antibiotics' substitute in poultry farming.

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Section: Introductionmentioning

confidence: 99%

Feed-additive probiotics accelerate yet antibiotics delay intestinal microbiota maturation in broiler chicken

et al. 2017

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“…Such diseases are most commonly treated by use of the surface application of commercial antibiotics. Suitable prebiotic substrates are, for example polyunsaturated fatty acids (PUFAs) which are richly represented in flaxseed (Rodriguez-Leyva et al, 2010;Nemcová et al, 2012;Andrejčáková et al, 2016;Sopková et al, 2017). The effect of probiotics, for improved effectiveness, may be potentiated by special natural substrates used as prebiotics (Nemcová et al, 2010).…”

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confidence: 99%

“…The effect of probiotics, for improved effectiveness, may be potentiated by special natural substrates used as prebiotics (Nemcová et al, 2010). Flaxseed is the richest plant source of n-3 PUFA ALA which, together with its derivativeseicosapentaenoic (EPA, C20:5 n-3) and docosahexaenoic (DHA, C22:6 n-3) acids are unique for their mostly pronounced cardioprotective (Rodriguez-Leyva et al, 2010), hypocholesterolemic (Sopková et al, 2017), hepatoprotective (Andrejčáková et al, 2016), anti-inflammatory (Liu et al, 2003) and neuroprotective (Contreras, 2012) effects on the organisms. Polyunsaturated fatty acids, such as linoleic (LA, C18:2 n-6) and α-linolenic (ALA, C18:3 n-3) acids are essential for humans and other animals.…”

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confidence: 99%

Supplemental flaxseed modulates ovarian functions of weanling gilts via the action of selected fatty acids

Vlčková

Andrejčáková

Hertelyová

et al. 2018

Animal Reproduction Science

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The aim of this study was to examine the influence of dietary flaxseed on the endocrine and ovarian functions of weanling gilts challenged with E. coli and Coronavirus infections treated with dietary probiotic cheeses and to understand the possible mechanisms of its effects on ovarian function. Probiotics were used as a natural substitution for antibiotics and 10% dietary flaxseed is an effective prebiotic which supports the action of probiotics and has other beneficial effects on the organism. Probiotics with or without flaxseed were fed to weanling gilts starting 10 days before and lasting up until 14 days after weaning. The ovaries were measured and histologically analysed. The blood samples for the levels of steroid hormones and insulin-like growth factor I (IGF-I) were assessed using immunoassays and the levels of fatty acids were assessed using gas chromatography. All samples were collected on the day of weaning and 14 days after weaning. On the day of weaning, increased levels of linoleic acid and IGF-I was associated with higher body weight. The steroid hormones were not affected by the diet. The conversion of alpha-linolenic acid (ALA) to timodonic (EPA) and cervonic (DHA) acids were lower compared to controls, and together with high levels of myristic, palmitic and palmitoleic acids was associated with the higher proliferation and lower apoptosis in the primordial, primary and secondary follicles; although the inhibition of the cell cycle was observed in relation to the low level of eicosadienoic acid. The high levels of ALA, EPA and DHA and the low levels of myristic, palmitic and palmitoleic acids may have been the effect of flaxseed feeding 14 days post-weaning and may have had a reverse effect on the proliferation and apoptosis of ovarian follicles. These data suggest that flaxseed may suppress the follicle development in weanlings via the stimulation of apoptosis and the inhibition of proliferation via the modulation of the metabolism of selected fatty acids.

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“…Through such mechanisms, the dietary PUFAs may positively affect the health of weaners and support their rapid adjustment to the character of post-weaning diet [21]. The high content of essential ω-3 alpha-linolenic acid (ALA) in flaxseed may positively affect the serum levels of lipoproteins and triacylglycerols [31] and affect the animal products nutritionally by additional ω-3 PUFAs produced at biosynthesis in animal tissues [18]. [18,40].…”

Section: Introductionmentioning

confidence: 99%

The Influence of Probiotic Lactobacilli and Flaxseed on the Health of Weaned Piglets and Metabolism of Polyunsaturated Fatty Acids (PUFAs)

et al. 2016

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This study investigated for 14 days post-weaning, the influence of dietary supplementation of synbiotics in the form of probiotic cheeses containing cultures of L. plantarum and L. fermentum and crushed flaxseed (source of ω-3 polyunsaturated fatty acids — PUFAs and fibre) on 36 commercial piglets originating from an infected herd (Coronavirus and E. coli) during the critical period of weaning. We focused on the health and metabolism of PUFAs in this critical period of a piglet’s life. The dietary supplementation positively affected: the overall health state of weaners, reduced diarrhoea by 29 % by 14 days post-weaning and significantly increased the counts of lactic acid bacteria, bifidobacteria and the production of volatile fatty acids. The PUFA concentrations in the m. biceps femoris of the piglets were analysed by gas chromatography. High levels of ω-3 alpha-linolenic acid (ALA) in flaxseed increased significantly the level of ALA, eicosapentaenic acid (EPA) and docosahexaenic acid (DHA) in the pig muscles on days 7 and 14 post-weaning. The levels of ω-6 linolenic acid (LA) were less affected by the diet, but were increased on day 14 post-weaning, while the conversion products of LA, and arachidonic acid (AA), were decreased on days 7 and 14. The increased level of dietary ALA favoured the activity of Δ-6-desaturase for the conversion of ALA to EPA and DHA, at the expense of AA synthesis from LA. The ability of synbiotics to incorporate high levels of DHA in the pig muscles appear prospective for improving the nutritional properties of pork and reducing the occurrence of civilization diseases in consumers of this product of animal origin.

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The application of probiotics and flaxseed promotes metabolism of n-3 polyunsaturated fatty acids in pigs

Cited by 24 publications

References 37 publications

Feed-additive probiotics accelerate yet antibiotics delay intestinal microbiota maturation in broiler chicken

Feed-additive probiotics accelerate yet antibiotics delay intestinal microbiota maturation in broiler chicken

Supplemental flaxseed modulates ovarian functions of weanling gilts via the action of selected fatty acids

The Influence of Probiotic Lactobacilli and Flaxseed on the Health of Weaned Piglets and Metabolism of Polyunsaturated Fatty Acids (PUFAs)

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