The application of platelet‐rich plasma for skin graft enrichment: A meta‐analysis

Abstract

Existing evidence demonstrated that the role of platelet‐rich plasma (PRP) in skin graft enrichment is uncertain. The aim of this study was to evaluate the efficacy and safety of PRP for skin graft. PubMed, EMBASE, Web of Science, and Cochrane Library databases were searched for randomised controlled trials that compared outcomes of skin graft treated with PRP versus those treated with blank controls. The outcomes mainly included the rate of skin graft take, number of skin graft loss and haematoma formation, and complications. There were 11 studies involving a total of 910 cases of skin grafts. Compared with the control group, PRP group had a significantly higher rate of skin graft take (mean difference = 5.47%; 95% confidence interval [CI], 2.80%‐8.14%; P < .0001), fewer number of skin graft loss (risk ratio [RR] = 0.26; 95% CI, 0.13‐0.55; P = .0004) and fewer cases of haematoma formation (RR = 0.24; 95% CI, 0.11‐0.54; P = .0006). There was no significant difference in the incidence of complications between two groups. This meta‐analysis summarises current evidence and indicates that PRP is a safe and effective adjuvant for skin graft enrichment.

Moving toward targeting the right phenotype with the right platelet-rich plasma (PRP) formulation for knee osteoarthritis

“…PRP preparations are used in different clinical areas, including dentistry, musculoskeletal medicine, plastic surgery, in vitro fertilisation and wound management. [18][19][20][21] PRPs are autologous or allogeneic blood derivatives. The latter have shown low immunogenicity as confirmed in a recent randomised controlled study, in which allogeneic PRP was used as an adjuvant in the management of chronic wounds.…”

“…PRP preparations are used in different clinical areas, including dentistry, musculoskeletal medicine, plastic surgery, in vitro fertilisation and wound management. 18 – 21 …”

Current art of combination therapy with autologous platelet‐rich plasma for stable vitiligo: A meta‐analysis

“…In the past decade, scientists have learned that the human body is an autogenous source of growth factors and fibrin clots. One of the representative autogenous regenerative biomaterials is platelet‐rich plasma (PRP) that contains moderate to high concentration of platelets together with multiple biomolecules (eg, chemokines, growth factors, adhesive proteins, and cytokines) and moderate concentration of leucocytes 5 . Activated platelets can release autogenous growth factors that may initiate signalling cascades and lead to multiple intracellular changes, promoting the proliferation, migration and differentiation of stem cells and regulating local inflammation and immune responses 5,6 .…”

Platelet‐rich plasma (PRP) for skin graft enrichment: The need for a universal PRP classification system

“…Platelet-rich plasma (PRP) for skin graft enrichment: The need for a universal PRP classification system Dear Editors, We read with great interest the article by Chen et al in a recent issue of the journal. 1 The meta-analysis mentioned above investigated the application of platelet-rich plasma (PRP) in skin graft enrichment. We would like to compliment, and add our findings on the available PRP classification system that can define the existing heterogeneity in PRP production protocols.…”

“…Among the 11 studies selected for analysis, the protocols used for PRP preparation differed widely, thereby limiting our ability to compare the results obtained. 1 In addition to that, most of the studies failed to define the components present in the PRP used, which may lead to bias. Such limitations can be avoided by defining the constituents of PRP based on a universal classification system.…”