“…ANN is a computational modeling tool that used to solve many complex real world problems due to its remarkable learning and generalization capabilities [27,28]. ANN is being used in water quality and water resources to estimate evaporation, evapotranspiration, rainfall, runoff, and nutrient transportation [29,30], accounting and fi nance [31], health and medicine [32,33], engineering and manufacturing [34,35], and marketing [36,37]. The ANN and MLR are used to predict the empirical relationships between refl ectance and plant stress levels of hypericum leaves under stress conditions using multiple regression, artifi cial neural network and ANFIS models.…”