The Application of Nanomaterials in Cardiovascular Diseases: A Review on Drugs and Devices

Dizaj, Solmaz Maleki; Rad, Abbas Afrasiabi; Safaei, Naser; Salatin, Sara; Ahmadian, Elham; Sharifi, Simin; Vahed, Sepideh Zununi; Lotfipour, Farzaneh; Shahi, Shahriar

doi:10.18433/jpps30456

Cited by 17 publications

(3 citation statements)

References 80 publications

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“…DES are widely utilized as they have been shown to reduce the rates of both ST and ISR compared to BMS in the long term 9 . Although DES have been substantially developed over the years, there are still concerns over the long term effectiveness due to delayed endothelialization, inflammatory reactions and neoatherosclerosis, leading to an increased risk of late-stage ST 10 , 52 – 54 . The bioresorbable stent was intended to solve some of the issues of DES but still suffer issues in terms of mechanical strength and negative effects of degradation products 55 .…”

Section: Discussionmentioning

confidence: 99%

A novel noble metal stent coating reduces in vitro platelet activation and acute in vivo thrombosis formation: a blinded study

Sandell,

Ericsson,

Al-Saadi

et al. 2023

Sci Rep

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Inherent to any stenting procedure is the prescription of dual antiplatelet therapy (DAPT) to reduce the platelet response. Clinical guidelines recommend 6–12 months of DAPT, depending on stent type, clinical picture and patient factors. Our hypothesis is that a nanostructured noble metal coating has the potential to reduce protein deposition and platelet activation. These effects would reduce subsequent thrombo-inflammatory reactions, potentially mitigating the need for an extensive DAPT in the acute phase. Here, a noble metal nanostructure coating on stents is investigated. Twelve pigs underwent endovascular implantation of coated and non-coated stents for paired comparisons in a blinded study design. The non-coated control stent was placed at the contralateral corresponding artery. Volumetric analysis of angiographic data, performed by a treatment blinded assessor, demonstrated a significant thrombus reduction for one of the coatings compared to control. This effect was already seen one hour after implantation. This finding was supported by in vitro data showing a significant reduction of coagulation activation in the coated group. This novel coating shows promise as an implant material addition and could potentially decrease the need for DAPT in the early phases of stent implementation.

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Section: Discussionmentioning

confidence: 99%

A novel noble metal stent coating reduces in vitro platelet activation and acute in vivo thrombosis formation: a blinded study

Sandell,

Ericsson,

Al-Saadi

et al. 2023

Sci Rep

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show abstract

“…Nanotechnology has been applied to a far greater extent in cancer therapy than in CVD. Despite this, its utility in CVD is of immense importance as its possible therapeutic benefits are linked to the role of the cardiovascular system in blood circulation, perfusion, and thus organ function [ 87 , 89 , 90 ]. The application of this mode of treatment delivery has been applied to combat various cardiovascular diseases [ 88 ].…”

Section: Nanoparticles For Drug Deliverymentioning

confidence: 99%

Tailoring Treatment in Cardiovascular Diseases: The Role of Targeted Therapies

Dankar,

Wehbi,

Refaat

2024

Pharmaceutics

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Cardiovascular diseases (CVDs) remain the leading cause of morbidity and mortality around the globe. To address this public health burden, innovative therapeutic agents are being developed to specifically target molecular and genetic markers. Various therapeutic modalities have been implemented, including vaccines, monoclonal or bispecific antibodies, and gene-based therapies. Such drugs precisely target the underlying disease pathophysiology, aiming at notable molecules such as lipid metabolism regulators, proinflammatory cytokines, and growth factors. This review focuses on the latest advancements in different targeted therapies. It provides an insightful overview of the current landscape of targeted cardiovascular therapies, highlighting promising strategies with potential to transform the treatment of CVDs into an era of precision medicine.

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“…Polymer-based NPs are colloidal particles composed of natural or synthetic polymers such as PLGA, polylactide (PLA), poly(amidoamine) (PAMAM), or poly(methyl methacrylate) (PMMA) are widely used synthetic polymers in NP preparation [54]. The particular characteristics of polymeric NPs include the feasibility of scale-up, high stability in biological fluids, the possibility to functionalize and modulate polymer degradation and the release of the loaded cargo as a function of internal/external stimuli [54]. Two major cate-gories of polymeric NPs are recognized as nanospheres and nanocapsules.…”

Section: Polymer-based Npsmentioning

confidence: 99%

Nanoparticle Formulations of Antioxidants for the Management of Oxidative Stress in Stroke: A Review

Salatin,

Farhoudi,

Farjami

et al. 2023

Biomedicines

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Stroke is currently one of the primary causes of morbidity and mortality worldwide. Unfortunately, there has been a lack of effective stroke treatment. Therefore, novel treatment strategies are needed to decrease stroke-induced morbidity and promote the patient’s quality of life. Reactive oxygen species (ROS) have been recognized as one of the major causes of brain injury after ischemic stroke. Antioxidant therapy seems to be an effective treatment in the management of oxidative stress relevant to inflammatory disorders like stroke. However, the in vivo efficacy of traditional anti-oxidative substances is greatly limited due to their non-specific distribution and poor localization in the disease region. In recent years, antioxidant nanoparticles (NPs) have demonstrated a clinical breakthrough for stroke treatment. Some NPs have intrinsic antioxidant properties and act as antioxidants to scavenge ROS. Moreover, NPs provide protection to the antioxidant agents/enzymes while effectively delivering them into unreachable areas like the brain. Because of their nanoscale dimensions, NPs are able to efficiently pass through the BBB, and easily reach the damaged site. Here, we discuss the challenges, recent advances, and perspectives of antioxidant NPs in stroke treatment.

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The Application of Nanomaterials in Cardiovascular Diseases: A Review on Drugs and Devices

Cited by 17 publications

References 80 publications

A novel noble metal stent coating reduces in vitro platelet activation and acute in vivo thrombosis formation: a blinded study

A novel noble metal stent coating reduces in vitro platelet activation and acute in vivo thrombosis formation: a blinded study

Tailoring Treatment in Cardiovascular Diseases: The Role of Targeted Therapies

Nanoparticle Formulations of Antioxidants for the Management of Oxidative Stress in Stroke: A Review

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