2012
DOI: 10.1016/j.febslet.2012.04.019
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The application of modular protein domains in proteomics

Abstract: The ability of modular protein domains to independently fold and bind short peptide ligands both in vivo and in vitro has allowed a significant number of protein-protein interaction studies to take advantage of them as affinity and detection reagents. Here, we refer to modular domain based proteomics as “domainomics” to draw attention to the potential of using domains and their motifs as tools in proteomics. In this review we describe core concepts of domainomics, established and emerging technologies, and rec… Show more

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Cited by 39 publications
(40 citation statements)
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“…Jadwin et al termed this "domainomics” [182]. In particular, applications of phosphotyrosine-recognition domains have been reported for therapeutic and diagnostic purposes.…”
Section: Introductionmentioning
confidence: 99%
“…Jadwin et al termed this "domainomics” [182]. In particular, applications of phosphotyrosine-recognition domains have been reported for therapeutic and diagnostic purposes.…”
Section: Introductionmentioning
confidence: 99%
“…Moreover, the usage of these tools in EvoProDom provides a general method to obtain protein domain content and orthologous protein annotation. This method may be applicable to other research fields such as proteomics (9), protein design (10) and host-virus interactions (11). Thus, EvoProDom presents a novel model for protein evolution based on “mix and merge” of protein domains rather than DNA based models.…”
Section: Discussionmentioning
confidence: 99%
“…By applying these protein sequence-based methods to obtain protein domain content and orthologous protein annotation, new organisms were easily added to EvoProDom. Moreover, this method is unique to EvoProDom and is applicable to other protein domain-based applications such as proteomics (9), protein design (10) and host-virus interactions (11).…”
Section: Methodsmentioning
confidence: 99%
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“…The availability of complete genome sequences for many organisms, coupled with a vast increase in the number of proteomic and protein-interaction data sets, have facilitated a broader perspective on modular binding domains and their role in signalling; the field has transitioned from 'discovery mode' to an appreciation of the full range and scope of the interactions that are mediated by modular domains 82 . We know roughly how many of each class of domain are present in various organisms and in how many different proteins they are found (see the figure, part a, for key examples).…”
Section: Box 1 | Domainomicsmentioning
confidence: 99%