The application of ligands with planar chirality in asymmetric synthesis

Abstract

A series of chiral ligands with planar chirality were synthesized, and have been shown to be highly ef®cient catalysts in some asymmetric reactions. The role of central and planar chirality in ligands with multi-chirality was also discussed.

Induction of Planar Chirality Using Asymmetric Click Chemistry by a Novel Desymmetrisation of 1,3‐Bisalkynyl Ferrocenes

“…The results reported here fill this gap and complete the range of types of enantiopure structures that can be addressed using the new asymmetric “click” approach. Planar chiral multiply‐substituted ferrocenes are an important class of molecules, and in recent years they have come into prominence as scaffolds for chiral ligands that now find widespread use in asymmetric catalysis . While there are already many important examples of preparations of non‐racemic substituted ferrocenes in the literature, most rely on classic directing groups such as oxazolines,[7a] acetals[7b] and Ugi's amine.…”

Katalytische, stereoselektive ortho‐Lithiierung eines Ferrocenderivats

“…[1] Die Stereoinformation wird im Allgemeinen durch eine diastereo-differenzierende Lithiierung in ortho-Position zu einer chiralen dirigierenden Gruppe eingeführt. [2] In der Vergangenheit wurde bereits eine Vielzahl Heteroatom-basierter chiraler dirigierender Gruppen hierfür untersucht.…”