The application of high-performance ultrasound probes increases anatomic depiction in obese patients

Heinitz, Sascha; Müller, Jürgen; Jenderka, Klaus-Vitold; Schlögl, Haiko; Stumvoll, Michael; Blüher, Matthias; Blank, Valentin; Karlas, Thomas

doi:10.1038/s41598-023-43509-9

Cited by 6 publications

(4 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This was comparable to our study. However, in our study, the latter subgroups also showed a multitude of structural anomalies with a higher frequency than in other studies (40), indicating the high sensitivity of the applied US methods (44). Consistent with recent studies (9,10,11), our results support the milder renal involvement in patients with BBS1 mutations.…”

Section: Renal Involvementsupporting

confidence: 92%

Ultrasound evaluation of kidney and liver involvement in Bardet-Biedl syndrome

Cetiner,

Finkelberg,

Schiepek

et al. 2024

Preprint

View full text Add to dashboard Cite

Background Bardet-Biedl syndrome (BBS) is a rare autosomal-recessive ciliopathy with pathogenic variants in at least 26 BBS genes. It affects multiple organs including kidney and liver, however, organ involvement differs widely regarding extent and time of first manifestation. Structural renal anomalies are an early feature with a frequency of > 50% and end-stage kidney disease (ESKD) cumulates to 25% in adolescence. Early-onset hyperphagia-associated obesity is another major symptom and contributes to liver pathology, presenting as steatosis/fibrosis. Aim of this study is the evaluation of high-end ultrasound (US) technologies including shear wave elastography (SWE), dispersion (SWD), and attenuation imaging (ATI) in BBS patients regarding their potential to discriminate liver and kidney tissue pathology at an early stage. Materials and Methods Patients with genetically proven BBS were recruited from the University Children’s Hospital of Essen and from BBS patient days hosted in Germany. Acute illness was an exclusion criterion. Clinical and laboratory data were extracted from patients’ digital records or medical letters. Results 49 BBS patients (24/49 male; aged 1.1–51.0 years, mean 17.8 years) were included in the study. Mean body weight (SDS 2.13 ± 1.33) and BMI (SDS 2.64 ± 1.18) were increased. Structural kidney abnormalities (dysplasia, cysts) were present in 75% (36/48) and persistent fetal lobulation in 44% (21/48). Renal function was impaired in 27% (13/49) and 3/13 had ESKD (kidney transplantation (n = 2), hemodialysis (n = 1)). Elevation of liver enzymes was detected in 38% (16/42). In 51% (25/49) ATI of liver tissue was increased, indicating hepatic steatosis, and correlated with BMI SDS, liver size, and enzymes. SWE was elevated in 61% (30/49) suggesting hepatic fibrosis and was associated with BMI and GGT. Patients with pathogenic variants in BBS10 showed a tendency towards higher ATI and reduced GFR, and had significantly higher BMI SDS. Conclusions We detected abnormalities of the kidney and liver in a higher percentage of BBS patients than previously reported, indicating a high sensitivity of the evaluated US applications. ATI detected liver pathology early (partially prior to liver enzymes) and revealed differences related to the affected genes. Evidence of tissue pathology at an early stage may improve diagnostics and the evaluation of therapeutic approaches.

show abstract

Section: Renal Involvementsupporting

confidence: 92%

Ultrasound evaluation of kidney and liver involvement in Bardet-Biedl syndrome

Cetiner,

Finkelberg,

Schiepek

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…However, our study was limited to healthy volunteers with normal BMIs (see Supplementary Table 2 ). Therefore, the observed differences might be more pronounced for more demanding ultrasound investigations, like in obese patients 24 .…”

Section: Discussionmentioning

confidence: 99%

Technical assessment of resolution of handheld ultrasound devices and clinical implications

Herzog,

Arsova,

Matthes

et al. 2024

Ultraschall Med

View full text Add to dashboard Cite

Purpose Since handheld ultrasound devices are becoming increasingly ubiquitous, objective criteria to determine image quality are needed. We therefore conducted a comparison of objective quality measures and clinical performance. Material and Methods A comparison of handheld devices (Butterfly IQ+, Clarius HD, Clarius HD3, Philips Lumify, GE VScan Air) and workstations (GE Logiq E10, Toshiba Aplio 500) was performed using a phantom. As a comparison, clinical investigations were performed by two experienced ultrasonographers by measuring the resolution of anatomical structures in the liver, pancreas, and intestine in ten subjects. Results Axial full width at half maximum resolution (FWHM) of 100µm phantom pins at depths between one and twelve cm ranged from 0.6–1.9mm without correlation to pin depth. Lateral FWHM resolution ranged from 1.3–8.7mm and was positively correlated with depth (r=0.6). Axial and lateral resolution differed between devices (p<0.001) with the lowest median lateral resolution observed in the E10 (5.4mm) and the lowest axial resolution (1.6mm) for the IQ+ device. Although devices showed no significant differences in most clinical applications, ultrasonographers were able to differentiate a median of two additional layers in the wall of the sigmoid colon and one additional structure in segmental portal fields (p<0.05) using cartwheel devices. Conclusion While handheld devices showed superior or similar performance in the phantom and routine measurements, workstations still provided superior clinical imaging and resolution of anatomical substructures, indicating a lack of objective measurements to evaluate clinical ultrasound devices.

show abstract

“…With obesity becoming a global epidemic, this is especially useful. Ultrasound signal gets attenuated and scattered as tissue thickness increases, especially adipose (Glanc et al, 2012;Uppot, 2018;Heinitz et al, 2023). Real-time imaging is being developed by utilizing fast scanning mechanisms and lasers with higher repetition rates (Manwar et al, 2018;Jeon et al, 2019;Kim et al, 2020a).…”

Section: Discussion and Outlookmentioning

confidence: 99%

Dual-modal photoacoustic and ultrasound imaging: from preclinical to clinical applications

Nyayapathi,

Zheng,

Zhou

et al. 2024

Front. Photon.

View full text Add to dashboard Cite

Photoacoustic imaging is a novel biomedical imaging modality that has emerged over the recent decades. Due to the conversion of optical energy into the acoustic wave, photoacoustic imaging offers high-resolution imaging in depth beyond the optical diffusion limit. Photoacoustic imaging is frequently used in conjunction with ultrasound as a hybrid modality. The combination enables the acquisition of both optical and acoustic contrasts of tissue, providing functional, structural, molecular, and vascular information within the same field of view. In this review, we first described the principles of various photoacoustic and ultrasound imaging techniques and then classified the dual-modal imaging systems based on their preclinical and clinical imaging applications. The advantages of dual-modal imaging were thoroughly analyzed. Finally, the review ends with a critical discussion of existing developments and a look toward the future.

show abstract

The application of high-performance ultrasound probes increases anatomic depiction in obese patients

Cited by 6 publications

References 25 publications

Ultrasound evaluation of kidney and liver involvement in Bardet-Biedl syndrome

Ultrasound evaluation of kidney and liver involvement in Bardet-Biedl syndrome

Technical assessment of resolution of handheld ultrasound devices and clinical implications

Dual-modal photoacoustic and ultrasound imaging: from preclinical to clinical applications

Contact Info

Product

Resources

About