The application of high-frequency and iTBS transcranial magnetic stimulation for the treatment of spasticity in the patients presenting with secondary progressive multiple sclerosis

Korzhova, J.; Chervyakov, A. V.; Poydasheva, A.; Kochergin, I A; Peresedova, A. V.; Zakharova, M. N.; Супонева, Н. А.; Черникова, Л. А.; Piradov, М. А.

doi:10.17116/kurort201658-13

Cited by 6 publications

(2 citation statements)

References 16 publications

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“…Our results are consistent with previous studies that have shown the efficacy of HF-rTMS [11] and iTBS [12,13] in the treatment of spasticity in patients with MS. In addition, the presence of an antispastic effect of HF-rTMS in patients with stroke, spinal trauma and cerebral palsy has been shown previously, as well as the effectiveness of iTBS in patients with stroke and spinal trauma [14,15].…”

Section: Discussionmentioning

confidence: 55%

High‐frequency repetitive transcranial magnetic stimulation and intermittent theta‐burst stimulation for spasticity management in secondary progressive multiple sclerosis

Korzhova

Bakulin

Синицын

et al. 2019

Euro J of Neurology

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Background and purpose The spasticity phenomenon is a significant factor in the development of disability. Repetitive transcranial magnetic stimulation (rTMS) is a promising treatment method for this disorder. Our aim was to compare the effects of two protocols of rTMS – the high‐frequency (HF) rTMS (20 Hz) and the intermittent theta‐burst stimulation (iTBS) – on the level of spasticity and concomitant symptoms in patients with secondary progressive multiple sclerosis with an analysis of the duration of the effects up to 12 weeks after the stimulation course. Methods Thirty‐four patients with secondary progressive multiple sclerosis and lower spastic paraparesis were randomized into three groups: (i) HF‐rTMS (20 Hz); (ii) iTBS; (iii) sham stimulation. Spasticity and spasticity‐associated symptoms were assessed by the Modified Ashworth Scale, the Subjective Evaluating Spasticity Scale (SESS), the numerical analog scale, the Modified Fatigue Impact Scale and the pain level scale. Results The Modified Ashworth Scale was significantly reduced after the stimulation course in the HF‐rTMS and iTBS groups. The SESS was reduced post‐intervention and at the two follow‐ups in the iTBS group, whilst HF‐rTMS produced an SESS reduction only at the 2‐week follow‐up, with no effects in the sham group. Conversely, reduction in pain and fatigue was found in the HF‐rTMS group. Conclusions The results show that HF‐rTMS and iTBS significantly reduce spasticity measured by the Modified Ashworth Scale, in contrast to sham stimulation. Some evidence was found in favor of a longer‐lasting effect of iTBS on the SESS and of a reduction in pain and fatigue after HF‐rTMS.

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Section: Discussionmentioning

confidence: 55%

High‐frequency repetitive transcranial magnetic stimulation and intermittent theta‐burst stimulation for spasticity management in secondary progressive multiple sclerosis

Korzhova

Bakulin

Синицын

et al. 2019

Euro J of Neurology

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“…For a long time, TMS has provided an indispensable neuroelectrophysiological method for the diagnosis and prognostic evaluation of many neurological diseases (Tremblay et al, 2019;Antczak et al, 2021). As a type of transcranial magnetic stimulation, repetitive transcranial magnetic stimulation (rTMS) plays a potential role in the treatment of MS, especially in improving fatigue and spasticity in patients with MS (Liu et al, 2019;Korzhova et al, 2018;Boutière et al, 2017;Korzhova et al, 2016;Abdelkader et al, 2013;Schippling et al, 2014). However, several recent studies contradicted the findings of previous studies (Dieguez-Varela et al, 2019;Gaede et al, 2018;Azin et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Effects of repetitive transcranial magnetic stimulation in multiple sclerosis: A systematic review and meta-analysis

Chen

Yin

et al. 2022

Multiple Sclerosis and Related Disorders

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This study aims to quantitatively evaluate and summarize the effectiveness of repetitive transcranial magnetic stimulation (rTMS) in the treatment of patients with multiple sclerosis (MS). Methods: The PubMed, EMBASE, Web of Science, Cochrane Database of Systematic Reviews, CBM, CNKI and Wanfang databases were searched for randomized controlled trails (RCTs) from their inception through July 10, 2021. RCTs that met the inclusion and exclusion criteria were included in the study, and RevMan software was used for meta-analysis. Outcome indicators included scores on the fatigue severity scale (FSS), modified Ashworth scale (MAS) and the H/M amplitude ratio of the Soleus H reflex. When p < 0.05, the difference was considered significant. Results: A total of 10 articles were included in this study, with 8 of them in the quantitative synthesis. The metaanalysis showed that the short-term effect of rTMS treatment for the MAS was better than that of the control treatment (95% CI: − 1.27 to − 0.25, p = 0.004); and compared with the control group, the effect of rTMS treatment for the H/M ratio showed a significant effect (95% CI: − 0.12 to − 0.03, p = 0.002); while the treatment effect for the FSS was not significant (95% CI: − 4.87 to 1.28, p = 0.25). Conclusion: Our results provide preliminary evidence for the treatment of patients with MS by rTMS, especially for improving spasticity, but further research is needed to evaluate its effects on fatigue.

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Emerging Non-Pharmacologic Treatments

Mas

Francisco

2022

Spasticity and Muscle Stiffness

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The application of high-frequency and iTBS transcranial magnetic stimulation for the treatment of spasticity in the patients presenting with secondary progressive multiple sclerosis

Cited by 6 publications

References 16 publications

High‐frequency repetitive transcranial magnetic stimulation and intermittent theta‐burst stimulation for spasticity management in secondary progressive multiple sclerosis

High‐frequency repetitive transcranial magnetic stimulation and intermittent theta‐burst stimulation for spasticity management in secondary progressive multiple sclerosis

Effects of repetitive transcranial magnetic stimulation in multiple sclerosis: A systematic review and meta-analysis

Emerging Non-Pharmacologic Treatments

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