The application of cryosurgery in the treatment of lung cancer

Maiwand, M. Omar; Evans, Joanna M.; Beeson, Julia

doi:10.1016/j.cryobiol.2003.12.003

Cited by 51 publications

(18 citation statements)

References 18 publications

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“…In the largest case series comprising 521 patients, cryotherapy appeared effective in the treatment of malignant endobronchial obstruction 58. Technical success as judged by restoration of airway patency was 61% and improvement occurred in symptoms such as haemoptysis (61–76.4%), cough (69%) and dyspnoea (59–81%).…”

Section: Therapeutic Procedures For Malignant Disease: Malignant Airwmentioning

confidence: 99%

British Thoracic Society guideline for advanced diagnostic and therapeutic flexible bronchoscopy in adults

Rand

Barber²,

Goldring³

et al. 2011

Thorax

171

180

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Section: Therapeutic Procedures For Malignant Disease: Malignant Airwmentioning

confidence: 99%

British Thoracic Society guideline for advanced diagnostic and therapeutic flexible bronchoscopy in adults

Rand

Barber²,

Goldring³

et al. 2011

Thorax

171

180

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“…Radiofrequency ablation, chemother- 7, 8, 8, 8, 9, 9, 10, 10, 10, 10, 12, 16, 17, 17, 17, 18, 21, 22, 22, 22, 24, 34, 36, 36, 38, 39 4, 5, 5, 8, 9, 11, 32 P value 0.0153 apy and other palliative therapies are possible options in such patients [13,14]. With advances in cryosurgery and imaging techniques, percutaneous cryoablation has increasingly been used to successfully treat lung cancer [9,[15][16][17]. This approach avoids the risks of thoracic surgery, decreases the likelihood of complications, and improves patients' quality of life.…”

Section: Discussionmentioning

confidence: 98%

Carcinoembryonic antigen as prognostic factor for metastatic non-small cell lung cancer by percutaneous cryosurgery

Tang

Niu

et al. 2013

CBM

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Carcinoembryonic antigen (CEA) is a prognostic marker for early-stage non-small cell lung cancer (NSCLC), and cryoablation is a new therapeutic alternative for lung cancer. We determined whether cryoablation-induced changes in serum CEA levels correlated with tumor type (adenocarcinoma or squamous carcinoma) and treatment type (comprehensive therapy [cryoablation of all intra- and extrapulmonary tumors] or palliative therapy [cryoablation of only extrapulmonary tumors]) in patients with metastatic NSCLC, and assessed whether pre-treatment CEA levels predicted overall survival (OS). We retrospectively reviewed the clinical data of 88 patients with metastatic NSCLC who underwent comprehensive (62 patients) or palliative (26 patients) therapy. Pre- and post-cryoablation serum CEA levels and overall survival were determined for all patients. Cryoablation significantly reduced CEA levels in adenocarcinoma, but not squamous carcinoma, patients. Among adenocarcinoma patients, the cryoablation-induced reduction in CEA levels was significantly greater after comprehensive treatment than after palliative treatment; the OS of patients under comprehensive cryoablation was longer than those under palliative treatment. Among adenocarcinoma patients receiving comprehensive cryoablation, OS was significantly longer in those with normal pre-treatment serum CEA levels than in those with abnormal pre-treatment serum CEA levels. Pretreatment level and change of serum CEA can be a good indicator for therapeutic effects and OS in metastatic NSCLC patients under percutaneous cryosurgery.

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“…Treatment by tumor ablation is a type of method which includes radiofrequency and microwave thermoablation therapy as well as the more recently developed cryosurgery ablation which was introduced at the beginning of this century [10][11][12] . These measures of ablation have been used for treating several neoplasms including lung carcinoma [13,14] . The function of cryosurgery ablation in cancer treatment is mainly to destroy the malignant tissue and cells.…”

Section: Discussionmentioning

confidence: 99%

Clinical effects of treatment for lung cancer with double points cryoablation through percutaneous puncture guided by computed tomography

Zao

Teng

Fang

et al. 2009

Clin. Oncol. Cancer Res.

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OBJECTIVE To investigate the clinical eff ects of the application of double points cryoablation through percutaneous puncture for advanced lung cancer patients. METHODS Forty-one patients diagnosed with stage III-IV pulmonary carcinoma were selected for the study. The patients were found to have from 1 to 3 foci of carcinoma, and in each case the disease was limited to one lung. The study patients were divided randomly into 3 groups. There were 16 cases receiving routine chemotherapy and radiotherapy in group I, 13 cases treated with cryoablation at a single point in group II, and 12 cases treated with cryoablation at 2 points simultaneously in group III. The patients in the 2 cryoablation groups also received the same treatment as the patients did in group I. The clinical eff ects were evaluated within 6 months aft er treatment, and the survival rate was followed-up for 3 years. RESULTS The clinical eff ects were improved signifi cantly aft er treatment in group II and in group III compared with those in group I (P < 0.05), including an enhanced regressive rate of 21%, postponed tumor progression of 50.58% and a clinical benefi t rate of 92%. The effective rate of regression in group III was higher than that in group II, 43.59% (P < 0.05), and the 3-year survival rate was 37.25%. Signifi cant diff erences in side eff ects were not found between the 2 cryoablation groups. C O N C L U S I O NC r y o s u r g e r y a b l a t i o n a t 2 p o i n t s , simultaneously, and directed at 1 foci might improve the eff ects of treatment and the prognosis of lung cancer patients, when used in combination with routine treatment.

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The application of cryosurgery in the treatment of lung cancer

Cited by 51 publications

References 18 publications

British Thoracic Society guideline for advanced diagnostic and therapeutic flexible bronchoscopy in adults

British Thoracic Society guideline for advanced diagnostic and therapeutic flexible bronchoscopy in adults

Carcinoembryonic antigen as prognostic factor for metastatic non-small cell lung cancer by percutaneous cryosurgery

Clinical effects of treatment for lung cancer with double points cryoablation through percutaneous puncture guided by computed tomography

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