The importance of maintaining controlled blood glucose and preventing complications in individuals with type 2 Diabetes Mellitus (DM) hinges significantly on self-care practices. A contributing factor to insufficient self-care, impacting quality of life, is the inadequate execution of self-regulation. This research aims to formulate a self-regulation model, grounded in individual and family self-management theory, to enhance self-care among individuals with type 2 DM. Employing a quantitative approach through cross-sectional methods, this study involved a sample of 115 type 2 DM patients in Sidenreng Rappang City. Structural Equation Modeling-Partial Least Squares (SEM-PLS) served as the analytical method. The findings revealed that the self-regulation process among T2DM patients significantly influences their ability to engage in self-care. The interpretation of the illness directly affects the coping mechanisms and emotional responses of those affected. Both the interpretation of the disease and emotional responses play pivotal roles in shaping coping mechanisms. Furthermore, it was established that interpretations are influenced by individual factors, disease representations, environmental factors, and family support. The self-regulation process is formed by coping mechanisms that, in turn, significantly impact the self-care practices of individuals dealing with type 2 Diabetes Mellitus (DM) while addressing their health concerns.