The application of 1,8-cineole, a terpenoid oxide present in medicinal plants, inhibits castor oil-induced diarrhea in rats

Jalilzadeh-Amin, Ghader; Maham, Masoud

doi:10.3109/13880209.2014.935862

Cited by 41 publications

(22 citation statements)

References 23 publications

(24 reference statements)

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“…This was further supported by the fact that isolated constituents from the leaves of this plant are known to suppress the biosynthesis of eicosanoids both in vivo and in vitro [ 41 ]. Certain flavonoids, tannins and terpenoids revealed antidiarrheal activities via a multitude of mechanisms [ 42 – 44 ]. Most of the aforementioned secondary metabolites were screened from the leaves of this plant so far [ 45 ].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the antidiarrheal activity of the leaf extracts of Myrtus communis Linn (Myrtaceae) in mice model

Sisay

Engidawork

Shibeshi

2017

BMC Complement Altern Med

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Background Myrtus communis L. has a folkloric repute for the management of diarrhea and dysentery in different parts of the world. However, the safety and efficacy of the leaf extract have not been scientifically validated in animal model. This study was, therefore, aimed to investigate the antidiarrheal effect of 80% methanol extract (80ME) and solvent fractions of the leaves of Myrtus communis L. in mice.MethodsThe antidiarrheal activity of the 80ME and solvent fractions was evaluated against castor oil induced diarrheal model, charcoal meal and enteropooling tests. For the 80%ME, the test groups received 100, 200 and 400 mg/kg of the extract. In case of fractions, the test groups received various doses of fractions (200, 300, 400 mg/kg and an additional dose of 800 mg/kg for the aqueous fraction (AF)), where as negative controls received the vehicle (10 ml/kg) and positive controls received loperamide (3 mg/kg).ResultsThe 80ME at 200 mg/kg (p < 0.05) & 400 mg/kg (p < 0.01) as well as the chloroform fraction (CF) and methanol fraction (MF) at 400 mg/kg (p < 0.05) significantly delayed the onset of diarrhea. Besides, the 80ME (at all tested doses) and both of these fractions (at 300 & 400 mg/kg) significantly decreased the frequency and weight of fecal outputs. Results from the charcoal meal test revealed that the 80ME, at all doses, (p < 0.001) as well as the CF and MF at 300 mg/kg (p < 0.05) & 400 mg/kg (p < 0.001) produced a significant anti-motility effect. Similarly, in the entero-pooling test, the 80ME (at all tested doses) (p < 0.01) as well as the CF and MF (at 300 & 400 mg/kg, p < 0.05) produced a significant decline in the weight and volume of intestinal contents, whereas the AF revealed significant effect (p < 0.05) at dose of 800 mg/kg only.ConclusionThe study demonstrated that the 80ME and solvent fractions contain bioactive constituents that have antidiarrheal activity. Therefore, this study provides a scientific support for the acclaimed traditional use of Myrtus communis L for the treatment of diarrheal diseases.

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Section: Discussionmentioning

confidence: 99%

Evaluation of the antidiarrheal activity of the leaf extracts of Myrtus communis Linn (Myrtaceae) in mice model

Sisay

Engidawork

Shibeshi

2017

BMC Complement Altern Med

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“…Many such EOs are used for pharmaceutical purposes and in perfumery. The eucalyptus oils used as pharmaceuticals are rich in 1,8cineole [8][9][10][11]. E. alba is native to northern Australia, Papua New Guinea and Timor, and has been planted throughout tropical areas.…”

Section: Introductionmentioning

confidence: 99%

The Essential oil of Eucalyptus alba L. Growing on the Salt Zone of Fatick (Senegal) as a Source of 1,8Cineole and Their Antibacterial Activity

Tine

Diallo

Diop

et al. 2020

J. Drug Delivery Ther.

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Members of the genus Eucalyptus are potential sources of number of commercial essential oils and aromachemicals. In present study, the essential oils isolated by hydrodistillation from the leaves of Eucalyptus alba were analyzed by GC-FID and GC-MS. Essential oil yields ranged from 2.41 to 4.35%. In total 18 constituents were identified, accounting for 99.0 to 99.7% of the total compositions. 1,8-cineole was present in all samples as the major component (76.5-88.1%). In addition to this compound, others that were found including limonene (3.8–8.6%), α-terpineol (1.4–2.8%), globulol (1.3–6.3%) and α-pinene (1.5–1.8%). The essential oil showed a strong antibacterial activity against S. aureus ATCC 29213 which is translated by an MIC of 1.25 mg/mL and good activity against E. coli ATCC 25922 (6.25 mg/mL) and E. faecalis ATCC 29212 (6.25 mg/mL). To our knowledge, our study is the first report of E. alba essential oils characterized by a high 1,8-cineole content (>76.5%). They may have potential applications in food and pharmaceutical products. Keywords: Eucalyptus alba, essential oils, antibacterial activity, 1,8-cineole and GC-SM

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“…1,8-Cineole (also known as eucalyptol), a monoterpene found naturally in many aromatic plants, has been widely reported for the bioactivities (Jalilzadeh-Amin and Maham, 2015). 1,8-cineole is one of the main activity compounds of the essential oil from Fructus Alpiniae Zerumbet which is widely used for CVDs in Guizhou China.…”

Section: Introductionmentioning

confidence: 99%

1,8-Cineole Ameliorates LPS-Induced Vascular Endothelium Dysfunction in Mice via PPAR-γ Dependent Regulation of NF-κB

Linghu

et al. 2019

Front. Pharmacol.

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1,8-Cineole (eucalyptol), a monoterpene, has been widely reported for the anti-inflammatory effects. Our previous data confirmed that 1,8-cineole ameliorated the inflammatory phenotype of human umbilical vein endothelial cells (HUVECs) by mediating NF-κB expression in vitro. At present, we investigated the protection effects of 1,8-cineole on vascular endothelium in lipopolysaccharide (LPS)-induced acute inflammatory injury mice and the potential mechanisms involved in the protection in HUVECs. Results from enzyme linked immunosorbent assays revealed that 1,8-cineole suppressed the secretion of interleukin (IL)-6 and IL-8 and increased the expression of IL-10 in the serum of LPS-induced mice. 1,8-Cineole reduced the inflammatory infiltration and the expression of vascular cell adhesion molecular 1 (VCAM-1) in the sections of thoracic aorta in LPS-induced acute inflammatory mice. Western blotting indicated that 1,8-cineole significantly decreased the phosphorylation of NF-κB p65 and increased the expression of PPAR-γ in the thoracic aorta tissue. 1,8-Cineole increased the expression of PPAR-γ in LPS-induced HUVECs. 1,8-Cineole and rosiglitazone reduced the protein and mRNA levels of VCAM-1, E-selectin, IL-6, and IL-8 in LPS-induced HUVECs, which could be reversed by the action of GW9662 (inhibitor of PPAR-γ). 1,8-Cineole and rosiglitazone blocked the LPS-induced IκBα degradation and NF-κB p65 nucleus translocation, which could be reversed by the pretreatment of GW9662 or silence of PPAR-γ gene. In conclusion, 1,8-cineole attenuated LPS-induced vascular endothelial cells injury via PPAR-γ dependent modulation of NF-κB.

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The application of 1,8-cineole, a terpenoid oxide present in medicinal plants, inhibits castor oil-induced diarrhea in rats

Abstract: This study demonstrated antispasmodic and antisecretory activities of 1,8-cineole and rationalized the traditional use of the plant containing various levels of this terpene in the treatment of gastrointestinal complains such as diarrhea.

Cited by 41 publications

References 23 publications

Evaluation of the antidiarrheal activity of the leaf extracts of Myrtus communis Linn (Myrtaceae) in mice model

Evaluation of the antidiarrheal activity of the leaf extracts of Myrtus communis Linn (Myrtaceae) in mice model

The Essential oil of Eucalyptus alba L. Growing on the Salt Zone of Fatick (Senegal) as a Source of 1,8Cineole and Their Antibacterial Activity

1,8-Cineole Ameliorates LPS-Induced Vascular Endothelium Dysfunction in Mice via PPAR-γ Dependent Regulation of NF-κB

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