The application and progression of CRISPR/Cas9 technology in ophthalmological diseases

Hu, Xumeng; Zhang, Beibei; Li, Xiaoli; Li, Miao; Wang, Yange; Dan, Handong; Zhou, Jiamu; Wei, Yuanmeng; Ge, Keke; Li, Pan; Song, Zongming

doi:10.1038/s41433-022-02169-1

Cited by 12 publications

(8 citation statements)

References 108 publications

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“…Particular attention should be given to the preventive and therapeutic effects of compounds such as lanosterol, sulforaphane, 4-PBA, SIR agonists, astaxanthin, metformin, and melatonin. In addition, CRISPR/Cas9 technology is new and noteworthy research methodology [ 173 ]. By doing so, we will not only improve public health but also bring more treatment options and possibilities for enhancing the quality of life of our patients.…”

Section: Discussionmentioning

confidence: 99%

A bibliometric and visualized analysis of the pathogenesis of cataracts from 1999 to 2023

Shu,

Liu,

et al. 2024

Heliyon

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Section: Discussionmentioning

confidence: 99%

A bibliometric and visualized analysis of the pathogenesis of cataracts from 1999 to 2023

Shu,

Liu,

et al. 2024

Heliyon

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“… 23 , 41 There are many concerns regarding the potential risks associated with an in vivo CRISPR-Cas9 system, such as oncogenicity related to DSBs, 44 undesired off-target effects, and immune and inflammatory responses. 43 , 45 , 46 …”

Section: Discussionmentioning

confidence: 99%

“… 58 There is no effective treatment for retinal dystrophies caused by gene variants yet, but many efforts are being made to develop gene replacement therapies, which have demonstrated good efficacy and safety in ongoing clinical trials. 45 …”

Section: Discussionmentioning

confidence: 99%

Efficient correction of ABCA4 variants by CRISPR-Cas9 in hiPSCs derived from Stargardt disease patients

Siles

Ruiz-Nogales

Navinés-Ferrer

et al. 2023

Molecular Therapy - Nucleic Acids

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“…The mutation type is further identified by Sanger sequencing or high-throughput sequencing to generate mutant plant lines. This elaborate and systematic process ensures accurate editing of the target gene and generation of the desired plant line [7][8].…”

Section: Crispr/cas9 Gene Editing In Plantsmentioning

confidence: 99%

Research on the application of CRISPR/Cas9 gene editing technology in traditional Chinese medicine

2024

TNS

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Traditional Chinese medicine (TCM) is the collective term for the medical practices of all ethnic groups in China (both Han Chinese and ethnic minorities), reflecting the Chinese understanding of life, health, and illness over thousands of years. In addition, traditional herbal medicine has demonstrated its effectiveness in treating complex diseases that have challenged modern Western medicine, such as the use of Artemisia annua extracts to treat malaria, preparations based on traditional Chinese pharmacology to combat large-scale influenza outbreaks, and herbal preparations as an adjunctive therapy to cancer treatment. Currently, the development of traditional Chinese medicine is facing problems such as the loss of prescription knowledge and the degradation of the quality of cultivated species of herbs. This paper uses a literature review to analyze the application of CRISPR/Cas9 gene editing technology in medicinal plants. It also proposes directions that can solve the challenges facing traditional Chinese medicine based on the arrangement of existing literature, and foresees the future application of CRISPR/Cas9 gene editing technology in medicinal plant editing.

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The application and progression of CRISPR/Cas9 technology in ophthalmological diseases

Cited by 12 publications

References 108 publications

A bibliometric and visualized analysis of the pathogenesis of cataracts from 1999 to 2023

A bibliometric and visualized analysis of the pathogenesis of cataracts from 1999 to 2023

Efficient correction of ABCA4 variants by CRISPR-Cas9 in hiPSCs derived from Stargardt disease patients

Research on the application of CRISPR/Cas9 gene editing technology in traditional Chinese medicine

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