The Appliance of A-PRF and CGF in the Treatment of Impacted Mandibular Third Molar Extraction Sockets—Narrative Review

Abstract

Tooth extractions, especially of impacted lower third molars, are among the most common procedures performed in dental practices. The continuity of the patient’s oral mucosa, which is interrupted during them, can manifest itself in general discomfort, pain, swelling, and even trismus. In the age of cosmetic dentistry, when lost teeth are restored through implant, prosthetic, and orthodontic treatment, each tooth extraction actually reduces the amount of available alveolar bone. This has prompted researchers to develop extraction sockets treatment procedures that reduce the negative consequences of surgical intervention while also enhancing the rate of alveolar bone and soft tissue regeneration using minimally invasive approaches. This is expected to enable or significantly facilitate further stages of treatment. The aim of this paper is to review the literature on the use of autologous blood preparations, which are considered to aid regenerative processes when applied to extraction sockets.

Allogenic Bone Graft in Dentistry: A Review of Current Trends and Developments

“…Some authors propose osseointegration, defined as the ability of a 2 of 12 biomaterial to bond chemically to the surface of the host's bone without the intervening fibrous tissue layer, as the fourth fundamental trait [2,4,6,7] Aside from bone regeneration and bone substitute materials, soft tissues can also be augmented using different materials, including autogenous and xenogenic [8]. Bloodderived autogenous materials, such as Plasma Rich in Growth Factors (PRGF), Leukocyte and Platelet-Rich Fibrin (L-PRF), Advanced Platelet-Rich Fibrin (A-PRF) and Concentrated Growth Factors (CGF), are worth mentioning as they can significantly improve healing and are widely used in many fields of modern dentistry [9][10][11].…”

Special Issue on Dental Materials: Latest Advances and Prospects—Volume II

“…The authors stated that, unfortunately, there is a lack of studies in the current literature comparing the amount of pro-inflammatory cytokines in a patient's peripheral blood to their levels after centrifugation in blood concentrates. Therefore, more studies are needed to clarify the correlation between pro-inflammatory cytokine levels and alveolar healing after extraction and assess the risk of treatment with blood concentrates in patients with systemic diseases causing chronic inflammation [6].…”