The apparent loss of cytochrome P-450 associated with metabolic activation of carbon tetrachloride.

Yamazoe, Yasushi; Sugiura, Masahiko; Kamataki, Tetsuya; Kato, Ryuichi

doi:10.1254/jjp.29.715

Cited by 20 publications

(1 citation statement)

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“…In CCI4-intoxicated rats, microsomal protein, content of cytochrome P-450, and NADPH cytochrome c reductase activity in the liver decreased significantly as previously reported (17). The hepatic content of cytochrome b5 was not altered by CCI4 administration.…”

Section: Effect Of Taurine Administration On Cci4supporting

confidence: 85%

Therapeutic effect of taurine administration on carbon tetrachloride-induced hepatic injury.

Nakashima¹,

TANIKO²,

Kuriyama³

1982

Jpn.J.Pharmacol

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Abstract-To determine the therapeutic efficacy of taurine administration on liver injury, the effect of taurine on hepatic lipid peroxide level following carbon tetrachloride (CCI4) administration was investigated. To CCI4 intoxicated rats (CCI4, 2 ml/kg, i.p.), 3 ml of a 10% aqueous solution of taurine was administered after CCI4 administration (at 12, 16, and 20 hr after), and rats were sacrificed at 24 hr after CCI4 administration in order to estimate the level of lipid peroxides in the liver. The decrease of hepatic lipid peroxidation induced by CCI4 was noticed in the taurine-treated rats. Taurine had no effect on mixed function oxidase activity in hepatic micro somes as well as no effect on hepatic antioxidant content in the CC14 intoxicated rats. Hepatic taurine content decreased significantly 12 and 24 hr after CCI4 administration, whereas oral administration of taurine to CCI4-intoxicated rats was able to protect these rats from hepatic taurine depletion.These results suggest that hepatic taurine may play a critical role on the protection of hepatocytes against hepatotoxins such as CCI4 and the administration of taurine may be useful in the treatment of hepatotoxin induced liver injury.

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Section: Effect Of Taurine Administration On Cci4supporting

confidence: 85%