The apolipoprotein E gene and its age-specific effects on cognitive function

Liu, Fan; Pardo, Luba M.; Schuur, Maaike; Sánchez‐Juan, Pascual; Isaacs, Aaron; Sleegers, Kristel; Koning, Ingrid de; Zorkoltseva, Irina V.; Axenovich, Tatiana I.; Witteman, Jacqueline C. M.; Janssens, A. Cecile J.W.; Swieten, John van; Aulchenko, Yurii S.; Oostra, Ben A.; Duijn, Cornelia M. van

doi:10.1016/j.neurobiolaging.2008.09.015

Cited by 60 publications

(65 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As anticipated [20], no APOE main effects were observed, and there were fewer interactions, i.e. the diabetes×APOE interaction was significant only for the global (p=0.04) and working memory composites (p=0.01), and the MMSE (p=0.04), and was marginal for similarities (p=0.07).…”

Section: Resultssupporting

confidence: 56%

See 1 more Smart Citation

Presence of the APOE ε4 allele modifies the relationship between type 2 diabetes and cognitive performance: the Maine–Syracuse Study

et al. 2009

View full text Add to dashboard Cite

Aims/hypothesis The primary aim of this study was to determine whether the presence of one or more APOE ε4 alleles modifies the association between diabetes (defined by glucose ≥7 mmol/l or treatment) and cognitive function. Methods Diabetic status and APOE genotype interactions were assessed cross-sectionally for 826 communitydwelling, stroke-free, non-demented individuals (526 nondiabetic non-APOE ε4 carriers, 174 non-diabetic APOE ε4 carriers, 87 diabetic APOE ε4 non-carriers, 39 diabetic APOE ε4 carriers) ranging in age from 50 to 98 years. Cognitive function was assessed using the Mini-Mental State Examination (MMSE), the similarities subtest from the Wechsler Adult Intelligence Scale, and four composite scores derived from 17 additional neuropsychological tests. Multiple linear regression analyses were employed to relate diabetes and APOE genotype to cognitive performance and to examine the interaction between these two risk factors as they relate to cognitive performance. Multiple cardiovascular disease risk factors were statistically controlled. Results With adjustment for age, education, sex, race/ ethnicity and APOE genotype, performance level was lower for the diabetic than for the non-diabetic group for the MMSE, the similarities subtest and each of the cognitive composites with the exception of the verbal memory composite. Interactions (p<0.05) between diabetes and APOE genotype were found for all but the visual-spatial memory/organisation composite. The negative association between diabetes and cognitive performance was of a higher magnitude for individuals who carry one or more APOE ε4 alleles. Results were similar with additional adjustment for cardiovascular disease and associated risk factors. Conclusions/interpretation The presence of one or more APOE ε4 alleles modifies the association between diabetes and cognitive function.

show abstract

Section: Resultssupporting

confidence: 56%

“…The final sample consisted of 826 participants. Persons under 50 years of age were excluded in the primary analysis because several studies indicate that APOE genotype does not relate to cognitive function in younger individuals [20,21]. A secondary set of analyses was done with the individuals under 50 years of age included.…”

Section: Methodsmentioning

confidence: 99%

Presence of the APOE ε4 allele modifies the relationship between type 2 diabetes and cognitive performance: the Maine–Syracuse Study

et al. 2009

View full text Add to dashboard Cite

show abstract

“…Crucially, APOE-related effects were more pronounced in older than younger individuals with respect to global cognitive ability and episodic memory. In line with this pattern, longitudinal studies have documented interactions between age and APOE, with increasing negative effects of e4 in persons older than 50 years on learning and episodic memory ( Figure 2) [22]. In another study, e4 carriers showed exacerbated decline in verbal memory and reasoning between 79 and 87 years of age [23].…”

Section: The Resource-modulation Hypothesismentioning

confidence: 54%

Aging-related magnification of genetic effects on cognitive and brain integrity

Papenberg

Lindenberger

Bäckman

2015

Trends in Cognitive Sciences

View full text Add to dashboard Cite

“…In line with this pattern, longitudinal studies have documented interactions between age and APOE on the memory and learning subdomains of the Adult Verbal Learning Test, with stronger negative effects of ε4 in persons older than 50 years than in those below 50 years (Liu et al 2010). Similarly, in older adults aged 79 years, the ε4 allele was associated with more rapid decline in verbal memory and abstract reasoning across 8 years (Schiepers et al 2012).…”

Section: Apoe Polymorphismmentioning

confidence: 74%

Genetics and Functional Imaging: Effects of APOE, BDNF, COMT, and KIBRA in Aging

et al. 2015

View full text Add to dashboard Cite

Increasing evidence from cross-sectional and longitudinal molecular-genetic studies suggests that effects of common genetic variations on cognitive functioning increase with aging. We review the influence of candidate genes on brain functioning in old age, focusing on four genetic variations that have been extensively investigated: APOE, BDNF, COMT, and KIBRA. Similar to the behavioral evidence, there are reports from agecomparative studies documenting stronger genetic effects on measures of brain functioning in older adults compared to younger adults. This pattern suggests disproportionate impairments of neural processing among older individuals carrying disadvantageous genotypes. We discuss various factors, including gene-gene interactions, study population characteristics, lifestyle factors, and diseases, that need to be considered in future studies and may help understand inconsistent findings in the extant literature.

show abstract

The apolipoprotein E gene and its age-specific effects on cognitive function

Cited by 60 publications

References 4 publications

Presence of the APOE ε4 allele modifies the relationship between type 2 diabetes and cognitive performance: the Maine–Syracuse Study

Presence of the APOE ε4 allele modifies the relationship between type 2 diabetes and cognitive performance: the Maine–Syracuse Study

Aging-related magnification of genetic effects on cognitive and brain integrity

Genetics and Functional Imaging: Effects of APOE, BDNF, COMT, and KIBRA in Aging

Contact Info

Product

Resources

About