The APOE4 allele is associated with a decreased risk of retinopathy in type 2 diabetics

Dlouhá, Lucie; Pelikánová, Terezie; Veleba, Jiri; Adámková, Věra; Lánská, Věra; Sosna, T; Pácal, Lukáš; Kaňková, Kateřina; Hubacek, Jaroslav A.

doi:10.1007/s11033-021-06581-w

Cited by 6 publications

(2 citation statements)

References 43 publications

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“…Although APOE polymorphism was not associated with T2D in central European Caucasian Czech population in a previous study, APOE4 allele was associated with the risk for diabetic retinopathy. In particular, female T2D patients with at least one APOE4 allele showed lower prevalence of retinopathy [35] .…”

Section: Discussionmentioning

confidence: 92%

The associations of PON1 and APOE polymorphisms with plasma lipid levels and the risk for late complications in type 2 diabetes patients

Klen¹,

Dolžan²,

Goričar³

2023

J Med Biochemistry

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Background: Besides good glycemic control, also control of lipid levels can effectively prevent or delay late type 2 diabetes (T2D) complications. As apolipoprotein E (APOE) and paraoxonase 1 (PON1) were shown to suppress atherosclerosis, we investigated the associations of common functional PON1 and APOE polymorphisms with plasma lipid levels and the risk for late complications in T2D patients. Materials and patients: Our retrospective genetic association study included 181 T2D patients genotyped for PON1 rs622, PON1 rs854560, APOE rs429358 and APOE rs7412. Results: PON1 rs622 G allele carriers had significantly lower LDL-C (p=0.024) and lower LDL/HDL ratio (p=0.031) under recessive model. Also in the subgroup of statin treated patients, PON1 rs622 G allele carriers had significantly lower LDL-C (p=0.019), lower total cholesterol/LDL ratio (0.043) and lower LDL/HDL ratio (0.009) when compared to non-carriers. After adjustment for clinical characteristics only associations of PON1 rs622 with macrovascular complications (p=0.002) and MI (p=0.041) remained significant. PON1 rs854560 and APOE genotypes were not associated with late T2D complications. Conclusion: Although our data show some associations between PON1 polymorphisms and lipid levels in T2D patients, as well as with late T2D complications, these associations do not seem to be clinically relevant in T2D patients.

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Section: Discussionmentioning

confidence: 92%

The associations of PON1 and APOE polymorphisms with plasma lipid levels and the risk for late complications in type 2 diabetes patients

Klen¹,

Dolžan²,

Goričar³

2023

J Med Biochemistry

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show abstract

“…All clinical data from the controls were obtained as self-reported. [24][25][26][27] All subjects were unrelated adult Caucasians. The study was conducted in accordance with the Declaration of Helsinki and approved by the Institutional Review Board (or Ethics Committee) of General University Hospital in Prague, First Faculty of Medicine Charles University (protocol code 89/19, date of approval 21 October 2019).…”

Section: Study Subjectsmentioning

confidence: 99%

Genetic risk score in patients with the APOE2/E2 genotype as a predictor of familial dysbetalipoproteinemia

Satny,

Todorovova,

Altschmiedova

et al. 2024

Journal of Clinical Lipidology

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Genetic polymorphisms of apolipoprotein E in nonarteritic anterior ischemic optic neuropathy

Chou

Sun

Wang

et al. 2022

Graefes Arch Clin Exp Ophthalmol

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The APOE4 allele is associated with a decreased risk of retinopathy in type 2 diabetics

Cited by 6 publications

References 43 publications

The associations of PON1 and APOE polymorphisms with plasma lipid levels and the risk for late complications in type 2 diabetes patients

The associations of PON1 and APOE polymorphisms with plasma lipid levels and the risk for late complications in type 2 diabetes patients

Genetic risk score in patients with the APOE2/E2 genotype as a predictor of familial dysbetalipoproteinemia

Genetic polymorphisms of apolipoprotein E in nonarteritic anterior ischemic optic neuropathy

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