The APOE ε4 allele increases the risk of impaired spatial working memory in obstructive sleep apnea

Cosentino, F.; Bosco, Paolo; Drago, Valeria; Prestianni, Giuseppina; Lanuzza, Bartolo; Iero, I.; Tripodi, Mariangela; Spada, Rosario S.; Toscano, Giuseppe; Caraci, Filippo; Ferri, Raffaele

doi:10.1016/j.sleep.2007.10.015

Cited by 75 publications

(73 citation statements)

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“…The APOE e4 allele has been associated with OSA, 32 and the adverse cognitive effects of OSA may be worse among allele carriers. 33,34 Studies in mice have demonstrated increased b-amyloid clearance during sleep. 35 In addition, sleep fragmentation appears to increase AD risk, 2 and the effect of APOE e4 on AD risk appears to be reduced with better sleep consolidation.…”

Section: Methods Study Population the Honolulu-asia Agingmentioning

confidence: 99%

Associations of brain lesions at autopsy with polysomnography features before death

et al. 2015

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Objective: To determine how sleep-disordered breathing, nocturnal hypoxia, and changes in sleep architecture in the elderly may be related to the development of the neuropathologic correlates of dementia.Methods: The Honolulu-Asia Aging Study is a prospective cohort study of Japanese American men in Honolulu, HI. We examined brain lesions at autopsy (Braak stage, neurofibrillary tangle and neuritic plaque counts, microinfarcts, generalized brain atrophy, lacunar infarcts, Lewy bodies [LBs], neuronal loss and gliosis in the locus ceruleus) in 167 participants who underwent polysomnography in 1999-2000 (mean age, 84 years) and died through 2010 (mean 6.4 years to death). Polysomnography measures included the apnea-hypopnea index, duration of apnea or hypopnea, duration of hypoxemia, minimum oxygen saturation (SpO 2 ), duration of slow-wave sleep (SWS, non-REM stage N3), and arousals.Results: Sleep duration with SpO 2 ,95% was associated with higher levels of microinfarcts (adjusted odds ratio [OR] 3.88, 95% confidence interval [CI] 1.10-13.76, comparing the highest to lowest quartiles of %sleep with SpO 2 ,95%). Greater SWS duration was associated with less generalized atrophy (adjusted OR 0.32, 95% CI 0.10-1.03, comparing highest to lowest quartiles of %sleep in SWS). LBs were less common with greater %sleep with SpO 2 ,95% (adjusted OR 0.17, 95% CI 0.04-0.78, comparing highest to lowest quartiles). Higher minimum SpO 2 during REM sleep was associated with less gliosis and neuronal loss in the locus ceruleus. Cognitive scores declined less among men with greater SWS duration. LRT 5 likelihood ratio test; NFT 5 neurofibrillary tangle; NP 5 neuritic plaque; OR 5 odds ratio; OSA 5 obstructive sleep apnea; PSG 5 polysomnography; SBP 5 systolic blood pressure; SDB 5 sleep-disordered breathing; SpO 2 5 oxygen saturation as measured by pulse oximetry; SWS 5 slow-wave sleep. Conclusions:Sleep-disordered breathing (SDB), 1 nocturnal hypoxia, 1 and changes in sleep architecture 2,3 may lead to dementia in the elderly. A causal association is supported by the finding that continuous positive airway pressure treatment in patients with obstructive sleep apnea (OSA) may improve cognition, even after dementia has developed. 4 It remains unclear how SDB, nocturnal hypoxia, and sleep architecture may be related to the development of brain lesions associated with dementia. Hypoxia and altered brain perfusion during sleep may cause neuronal injury, leading to impaired cognitive functioning. Alternatively, abnormalities in regions such as the locus ceruleus may alter sleep architecture or control

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Section: Methods Study Population the Honolulu-asia Agingmentioning

confidence: 99%

Associations of brain lesions at autopsy with polysomnography features before death

et al. 2015

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“…For this reason, most current studies have focused on the ApoE ε2, ε3, and ε4 variants to investigate disease-related genetic factors. The ε4 allele in particular is thought to be an effective factor in disease progression (3,16,18). In some studies, no association was found between ApoE gene variants and sleep apnea syndrome (23).…”

Section: Discussionmentioning

confidence: 99%

“…The ε2 variant is formed by coding of cysteine at codon 112 and cysteine amino acid at codon 158. The ε4 variant is formed by coding of arginine at codon 112 and arginine amino acid at codon 158 (16,21). The experiments were conducted in accordance with the protocol of the relevant company.…”

Section: Blood Sample Collection and Genotyping Studiesmentioning

confidence: 99%

“…It is known that ApoE has functions such as differentiation, cell growth, and regulation of the immune system, and that it is expressed in various organs such as the spleen, kidney, liver, and brain (16,17). ApoE has been found at high concentrations in the interstitial fluid, which is responsible for the redistribution of cholesterol to cells with low cholesterol from cells with excessively high cholesterol (17).…”

Section: Introductionmentioning

confidence: 99%

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The Effect of Different ApoE Genotypes and Other Risk Factors on Obstructive Sleep Apnea Syndrome Formation

Kıraç¹,

Yassa²,

Gezmis³

et al. 2017

tnd

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Objective: Obstructive sleep apnea syndrome (OSAS) is a disorder characterized by partial or complete narrowing of the pharyngeal airway during sleep. In this study it was aimed to investigate the relation between OSAS and different variants of the ApoE gene, and to identify other risk factors that may affect the development of the disease. Materials and Methods:Fifty-two patients with OSAS and 50 healthy volunteers were enrolled into the study. After collecting the necessary information associated with OSAS from the individuals, DNA was isolated from blood. ε2, ε3 and ε4 variants of Apolipoprotein E (ApoE) gene were investigated using real-time polymerase chain reaction. Results:When the groups were compared with each other, age, body mass index, total cholesterol, low-density lipoprotein (LDL), high-density lipoprotein, triglyceride, neck circumference, waist circumference, apnea hypopnea index, Epworth sleepiness scale, smoking, and daytime sleepiness were found statistically significant. The ε2 variant was found statistically high in the control group. Also, waist circumference, triglyceride and LDL levels were found statistically low in individuals with the ε2 genotype. In addition, triglyceride levels were found statistically high in individuals with the ε4 genotype. Conclusion:The presence of the ε2 variant in healthy individuals may have a protective effect against OSAS. In addition, the relation between different variants of ApoE with LDL and triglyceride levels demonstrates the overlap of genotype and phenotype data.Keywords: Obstructive sleep apnea syndrome, ApoE, real-time polymerase chain reaction Amaç: Obstrüktif uyku apne sendromu (OUAS), uyku esnasında faringeal hava yolunun kısmen veya tamamen daralması ile karakterize olan bir hastalıktır. Bu çalışmada OUAS ile apolipoprotein E (ApoE) genindeki çeşitli varyantların ilişkisinin araştırılması ve hastalık oluşumuna etki edebilecek diğer risk faktörlerinin incelenmesi amaçlanmıştır. Gereç ve Yöntem:Elli iki OUAS hastası ve 50 sağlıklı gönüllü birey çalışmaya dahil edilmiştir. Bireylerden OUAS ile ilişkili olabilecek gerekli bilgiler temin edildikten sonra, kandan DNA izolasyonu yapılmıştır. ApoE genindeki ε2, ε3 ve ε4 varyantlarının incelenmesi gerçek zamanlı polimeraz zincir reaksiyonu ile gerçekleştirilmiştir. The Effect of Different

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“…Evidence has shown that genetic determinants of upper-airway muscle activity, craniofacial structure, obesity, fat distribution, and respiratory control may interact and cause OSA (Casale et al, 2009). Most genetic association studies have focused on the TNF-α, ACE I/D, and APOE genes (Cosentino et al, 2008;Popko et al, 2008;Bhushan et al, 2009;Yakut et al, 2010). Bhushan et al (2009) reported that the frequency of the TNF-α (-308A) allele and serum TNF-α levels were significantly higher in obese Asian Indians with OSA.…”

Section: Discussionmentioning

confidence: 99%

Relationship between zinc finger protein 36 (ZFP36) gene polymorphisms and obstructive sleep apnea

Zhang

Abulikemu

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Recent data have indicated that inflammation may have an important correlation with obstructive sleep apnea (OSA). Studies have indicated a relationship between OSA and TNF-α gene polymorphisms. Zinc finger protein 36 (ZFP36) regulates TNF-α mRNAs. However, ZFP36 gene polymorphisms have not been investigated in OSA. Therefore, we conducted the present case-control study to assess whether variances in ZFP36 gene polymorphisms account for differences in TNF-α levels in patients with moderate-tosevere OSA. This case-control study aims to investigate the relationship between genetic variations in the ZFP36 gene and moderate-to-severe OSA. Three common single nucleotide polymorphisms of the ZFP36 gene (rs251864, rs3746083, and rs17879933) were evaluated in a group of patients with moderate-to-severe OSA (N = 408) and in a control Y. Zhang et al. 6734©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (2): 6733-6743 (2015) group (N = 394) by using TaqMan polymerase chain reaction analysis. The moderate-to-severe OSA group and the control group exhibited significant differences in the distributions of rs251864 and rs17879933 genotypes and alleles (P < 0.05). TNF-α levels were significantly different not only among the three rs251864 genotypes but also between the II genotype and the DD + ID genotypes of rs17879933. However, no significant differences in sleep apnea parameters in the three ZFP36 gene polymorphisms were observed. Logistic regression analyses demonstrated that TNF-α and the three ZFP36 gene polymorphisms were not independently associated with OSA. ZFP36 might be involved in TNF-α regulation. However, ZFP36 gene variants were not independent risk factors for moderate-to-severe OSA.

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The APOE ε4 allele increases the risk of impaired spatial working memory in obstructive sleep apnea

Cited by 75 publications

References 69 publications

Associations of brain lesions at autopsy with polysomnography features before death

Associations of brain lesions at autopsy with polysomnography features before death

The Effect of Different ApoE Genotypes and Other Risk Factors on Obstructive Sleep Apnea Syndrome Formation

Relationship between zinc finger protein 36 (ZFP36) gene polymorphisms and obstructive sleep apnea

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