The APOE ε2 allele is associated with increased plasma apolipoprotein E levels in patients with coronary artery disease

Pleva, Leoš; Kušnierová, Pavlína; Plevová, Pavlína; Hilscherová, Šárka; Karpíšek, Michal; Zapletalová, Jana; Faldynova, L.; Kovářová, Petra; Kukla, Pavel

doi:10.1016/j.crvasa.2016.11.011

Cited by 2 publications

(2 citation statements)

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“…Seven studies (including 18 comparisons) were employed in ε3ε4 versus ε3ε3 comparison. Nine [11][12][13][14][15][16][17][18][19] studies (with 20 comparisons involved) were recruited in E2 versus E3, E4 versus E3 and E2 versus E4 comparisons.…”

Section: Study Characteristicsmentioning

confidence: 99%

Relationship Between Serum C-reactive protein Levels and Apolipoprotein E Gene Polymorphism: A Meta-Analysis

Wang

Xiao-yin

et al. 2021

Preprint

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Background and Aim: Apolipoprotein E refers to a polymorphic protein involved in lipoprotein transport and metabolism. However, the relationship between Apo E gene polymorphism and serum CRP levels remains unclear. The present meta-analysis aimed to comprehensively assess the relationships between Apo E gene polymorphism and serum CRP levels. Method: Comprehensive search of all relevant documents published in PubMed, EMBASE, Web of science, Cochrane Library before April 2020. Calculate the standard deviation of mean (SMD) and 95% confidence interval (CI) with a random effects model. Compare serum CRP levels between different Apo E genotypes and isoforms. Use funnel plots to assess publication bias of studies involved. Results: On the whole, 9 studies including 173 different Apo E genotypes comparisons were involved in the present meta-analysis. Overall, the serum CRP level of the apo E ε3ε4 and ε4ε4 genotypes exhibit lower CRP levels as compared with ε3ε3 (OR= -0.21, 95% CI: -0.25, -0.16, P<0.00001; OR= -0.32, 95% CI： -0.39， -0.25, P<0.00001); Apo E ε2ε2 and ε2ε4 display higher CRP levels as compared with ε4ε4 (OR= 0.38, 95% CI: 0.16, 0.60, P=0.0006; OR= 0.38, 95% CI: 0.27, 0.49, P<0.00001). Moreover, Apo E E4 isoforms achieve lower CRP levels than E2 and E3 (OR= 0.22, 95% CI: 0.17, 0.26, P<0.00001; OR= 0.22, 95% CI: 0.15， 0.29, P<0.00001). Conclusions: As revealed from the present meta-analysis, serum CRP levels are different between different Apo E gene polymorphism, and Apo E genotypes with a higher risk of atherosclerosis exhibit lower serum CRP levels.

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Section: Study Characteristicsmentioning

confidence: 99%

Relationship Between Serum C-reactive protein Levels and Apolipoprotein E Gene Polymorphism: A Meta-Analysis

Wang

Xiao-yin

et al. 2021

Preprint

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“…APOE plays an essential role in the metabolism of LDL by enhancing its cellular uptake. In inflamed arteries, APOE is also produced by locally residing macrophages, which facilitates in removing of atherosclerosis clots by lowering the cholesterol levels in blood [10]. The APOE gene is located on chromosome 19, APOE polymorphisms (rs7412 and rs429385) resulted into the altered amino acids arrangement at position 130 and 176 as a consequence three different protein isoforms are produced which are called as APOE2, APOE3, and APOE4.…”

Section: Introductionmentioning

confidence: 99%

The association of apolipoprotein-E (APOE) gene polymorphisms with coronary artery disease: a systematic review and meta-analysis

Ashiq

2021

Egypt J Med Hum Genet

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Background Numerous studies have investigated the role of apolipoprotein E (APOE) polymorphisms in coronary artery disease (CAD), but some controversies exist regarding the outcomes as the results were not consistent and remain uncertain. Therefore, the present meta-analysis was conducted to evaluate the association of APOE polymorphisms with coronary artery disease. Methods All the relevant studies published in English language till August 2020 were identified by searching through various electronic databases. The complete data was independently extracted by the two researchers. The data were analyzed by using the Comprehensive Meta-Analysis program and MetaGenyo program. The pooled odds ratio was used to check the associations between CAD and APOE polymorphisms. The following genetic models were used to calculate the odds ratio: ε2 vs. ε3 and ε4 vs. ε3. Results In the final analysis, we include 12 studies regarding the role of APOE polymorphism in CAD. The pooled odds ratio for ε4 allele was higher (OR 2.00; 95% and CI, 1.48–2.71). There is no statistical significant association for ε2 allele with CAD (OR 1.38; 95% CI, 1.18–1.62). This analysis showed no publication bias exists in the current meta-analysis. Conclusions Our findings suggest that the apolipoprotein ε4 allele appears as a significant genetic risk factor for coronary artery disease while the ε2 allele is beneficial to alleviate the CAD risk. Trial registration Registered with PROSPERO International Prospective Register of Systematic Reviews. PROSPERO registration number CRD42020190464

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The APOE ε2 allele is associated with increased plasma apolipoprotein E levels in patients with coronary artery disease

Cited by 2 publications

References 20 publications

Relationship Between Serum C-reactive protein Levels and Apolipoprotein E Gene Polymorphism: A Meta-Analysis

Relationship Between Serum C-reactive protein Levels and Apolipoprotein E Gene Polymorphism: A Meta-Analysis

The association of apolipoprotein-E (APOE) gene polymorphisms with coronary artery disease: a systematic review and meta-analysis

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