The apical region of developing tooth root constitutes a complex and maintains the ability to generate root and periodontium‐like tissues

Abstract

The sustainable development ability of developing apical complex qualifies it as the growth center of tooth root and as a promising candidate source of cells for tooth root and periodontal regeneration.

Expression of the IGF-1, IGFBP-3 and IGF-1 receptors in dental pulp stem cells and impacted third molars

“…The strongest expression of IGF-1, IGFBP-3 and IGF-1R was evident in teeth with ongoing root development, especially in the incomplete apical base, where high proliferation and differentiation rates are normally observed (29). Furthermore, in accordance with previous studies of the potential roles of the IGF family in odontogenesis, we found that the expression of IGF-1, IGFBP-3 and IGF-1R declined when tooth development had been completed.…”

Attachment Ability of Human Apical Papilla Cells to Root Dentin Surfaces Treated with Either 3Mix or Calcium Hydroxide

“…Many types of cells, including APCs, have been hypothesized to play roles in the regenerative processes (8,(15)(16)(17). APCs have been advocated because of their high proliferation rate and mineralization potential (18,19). An evoked-bleeding step in regenerative procedures could recruit APCs into the root canal (17).…”

The Role of NFIC in Regulating Odontoblastic Differentiation of Human Molar Stem Cells from Apical Papilla

“…It's well established that HERS regulates the formation of organized root dentin through epithelial-mesenchymal interactions. The absence of HERS during the formation of dentin-like structures would cause odontoblast progenitor cells to form osteodentin without organized dentinal tubules, that resembled repair dentin [15]. The mechanisms behind the osteodentin formation and odontoblastlike cells differentiation remain uncertain.…”