The anxiolytic effects of midazolam during anticipation to pain revealed using fMRI

Wise, Richard G.; Lujan, Brandon J.; Schweinhardt, Petra; Peskett, G. D.; Rogers, Richard; Tracey, Irene

doi:10.1016/j.acpain.2007.08.013

Cited by 14 publications

(18 citation statements)

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“…Furthermore, anxious individuals are more likely to develop chronic pain 125 , and anxiolytic drugs can reduce chronic pain in some patients 124,125 . Increased activity in the anterior cingulate cortex (ACC) has been reported in individuals who are exposed to anxiety-inducing settings 127 and in individuals with anxiety disorders 128 . Thus, chronic pain and anxiety may be mutually reinforcing.…”

Section: Box 2 | Pain Anxiety and The Anterior Cingulate Cortexmentioning

confidence: 99%

Synaptic plasticity in the anterior cingulate cortex in acute and chronic pain

et al. 2016

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The anterior cingulate cortex (ACC) is activated in both acute and chronic pain. In this Review, we discuss increasing evidence from rodent studies that ACC activation contributes to chronic pain states and describe several forms of synaptic plasticity that may underlie this effect. In particular, one form of long-term potentiation (LTP) in the ACC, which is triggered by the activation of NMDA receptors and expressed by an increase in AMPA-receptor function, sustains the affective component of the pain state. Another form of LTP in the ACC, which is triggered by the activation of kainate receptors and expressed by an increase in glutamate release, may contribute to pain-related anxiety.

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Section: Box 2 | Pain Anxiety and The Anterior Cingulate Cortexmentioning

confidence: 99%

Synaptic plasticity in the anterior cingulate cortex in acute and chronic pain

et al. 2016

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“…Over the years, our group and others have made significant contributions towards the development of pharmacological neuroimaging-ie, the use of neuroimaging-based measures to determine target engagement and modulation of brain networks and mechanisms relevant to acute and chronic pain across different classes of compounds. 11,28,58,67,69,85,95,98,114,128,[133][134][135] Subjective ratings of pain and analgesia are influenced by many factors, as we have shown perhaps most strikingly in an earlier study. 9 Therefore, obtaining early information that a drug has target engagement and some efficacy against the mechanism being targeted in human experimental medicine models or patients, irrespective of the analgesic rating, is valuable and can hopefully lead to fewer good drugs being falsely failed and more poorer drugs being stopped earlier in analgesic drug development.…”

Section: Old Mechanisms: Still Going Strong With Translation To Patiementioning

confidence: 77%

Neuroimaging mechanisms in pain: from discovery to translation

Tracey

2017

PAIN

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“…-verarbeitung zu. So wurde in einer fMRT-Studie der anxiolytische Effekt von Benzodiazepinen auf die ängstli-che Erwartung einer Schmerzreizung untersucht und hierbei eine Reduktion der insulären Antwort festgestellt [72].…”

Section: Somatosensorische Verarbeitungunclassified

Untersuchungen zur zerebralen Verarbeitung von Schmerzen mit funktioneller Bildgebung

Valet

Sprenger

Tölle

2010

Schmerz

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Functional neuroimaging methods such as positron emission tomography (PET) or functional magnetic resonance imaging (fMRI) provide fascinating insights into the cerebral processing of pain. Neuroimaging studies have shown that no clearly defined "pain centre" exists. Rather, an entire network of brain regions is involved in the processing of nociceptive information, which leads to the subjective impression of "pain". Sophisticated study designs nowadays permit the characterisation of different components of pain processing. In this review, we summarise neuroimaging studies, which contributed to the characterisation of these different aspects of cerebral pain processing, such as somatosensory (discrimination of different stimulus modalities, noxious vs non-noxious, summation), emotional, cognitive (attention, anticipation, distraction), vegetative (homeostasis) and motor aspects.

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The anxiolytic effects of midazolam during anticipation to pain revealed using fMRI

Cited by 14 publications

References 0 publications

Synaptic plasticity in the anterior cingulate cortex in acute and chronic pain

Synaptic plasticity in the anterior cingulate cortex in acute and chronic pain

Neuroimaging mechanisms in pain: from discovery to translation

Untersuchungen zur zerebralen Verarbeitung von Schmerzen mit funktioneller Bildgebung

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