The anxiolytic effects of a Valerian extract is based on Valerenic acid

Becker, Axel; Felgentreff, Falko; Schröder, Helmut; Meier, Beat; Brattström, A.

doi:10.1186/1472-6882-14-267

Cited by 57 publications

(39 citation statements)

References 19 publications

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“…Awad et al (); Becker et al (); Khom et al (, ); Ortiz et al (); Ramharter and Multzer (); Santos et al (); Trauner et al ()…”

Section: Resultsmentioning

confidence: 99%

“…Valerenic acid as the principle constituent was identified as a subunit-specific allosteric modulator of GABA-A receptors, specifically acting as an agonist at β2/3 subunits in male RjHan:WI rat cortical tissues and in Xenopus oocytes tissue investigations, likely to interact with the loreclezole binding pocket (Becker, Felgentreff, Schroder, Meier, & Brattstrom, 2014;Khom et al, 2007Khom et al, , 2016Trauner et al, 2008).…”

Section: Valeriana Officinalis (Valerian)mentioning

confidence: 99%

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GABA‐modulating phytomedicines for anxiety: A systematic review of preclinical and clinical evidence

Savage

Firth

Stough

et al. 2017

Phytotherapy Research

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Anxiety disorders are chronic and functionally disabling conditions with high psychological stress, characterised by cognitive symptoms of excessive worry and focus difficulties and physiological symptoms such as muscle tension and insomnia. Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter within the central nervous system and is a key target of pharmacotherapies in the treatment of anxiety. Although current pharmaceutical treatments are often efficacious, they may cause undesirable side effects including cognitive decrements and withdrawal symptoms. Plant-based "phytomedicines" may provide novel treatment options, to act as an adjunctive or alternative to existing anxiolytic medications. As such, we conducted a systematic review to assess the current body of literature on anxiolytic phytomedicines and/or phytoconstituents.An open-ended search to 5 July 2017 was conducted using MEDLINE (PubMed), Scopus, and Cochrane library online databases and performed in a stepped format from preclinical to clinical investigations. Eligible studies must have had (a) in vitro evidence of GABA-modulating activity, (b) animal studies using anxiety models to test an anxiolytic effect, and (c) human clinical trials.Ten phytomedicines were identified as having preclinical investigations showing interaction with the GABA system, in addition to human clinical trials: kava, valerian, pennywort, hops, chamomile, Ginkgo biloba, passionflower, ashwagandha, skullcap, and lemon balm. Collectively, the literature reveals preclinical and clinical evidence for various phytomedicines modulating GABA-pathways, with comparative anxiolytic effect to the current array of pharmaceuticals, along with good safety and tolerability profiles.

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“…Awad et al (); Becker et al (); Khom et al (, ); Ortiz et al (); Ramharter and Multzer (); Santos et al (); Trauner et al ()…”

Section: Resultsmentioning

confidence: 99%

Section: Valeriana Officinalis (Valerian)mentioning

confidence: 99%

GABA‐modulating phytomedicines for anxiety: A systematic review of preclinical and clinical evidence

Savage

Firth

Stough

et al. 2017

Phytotherapy Research

View full text Add to dashboard Cite

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“…The EPM test was performed as previously described ( Becker, Felgentreff, Schröder, Meier, & Brattström, ; Romano et al, ). The plus maze consisted of four arms: two open arms (6 × 29.5 cm 2 ) and two closed arms (6 × 29.5 cm 2 ) enclosed by 55‐cm‐high walls.…”

Section: Methodsmentioning

confidence: 99%

Role of allopregnanolone biosynthesis in acute stress-induced anxiety-like behaviors in mice

Yoshizawa

Okumura

Nakashima

et al. 2017

Synapse

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The neurosteroid allopregnanolone (3α, 5α-tetra-hydroprogesterone: ALLO) elicits anxiolytic, anticonvulsant, and hypnotic anesthetic effects in vivo similar to those induced by other positive allosteric modulators of the GABA receptor. Endogenous ALLO has been shown to be rapidly elevated in the brain by acute stress paradigms, such as immobilization, in animal models. The present study was designed to ascertain the role of neurosteroid biosynthesis in the anxiety-like behavior induced by immobilization stress. Mice were exposed to an immobilization stressor for 2 h. After 24 h, the mice that had been immobilized did not behave significantly differently in the elevated plus maze (EPM) test and in the elevated open platform (EOP) test than the mice that had not been immobilized. In contrast, finasteride-pretreated immobilization stressed mice did behave significantly differently in the EPM and EOP tests. These findings suggest that ALLO biosynthesis contributes to stress resistance. Furthermore, the ALLO mimetic drug alfaxalone appeared to antagonize the effects of finasteride by significantly changing the behavior in the EPM test or in the EOP test in finasteride (10 mg kg )-pretreated immobilized mice. In addition, alfaxalone, unlike diazepam, did not affect the muscle tone of the mice, as measured by the grip strength test. These results suggest that alfaxalone is a promising anxiolytic candidate lacking benzodiazepine-like muscle-relaxant effects.

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“…Valerian, obtained mainly from the roots of Valeriana officinalis L. (Valerianaceae), is a natural agent broadly used as an alternative therapy for sleep disorders and anxiety (Houghton, 1999;Gooneratne, 2008;Becker et al, 2014;Gromball et al, 2014, Gharib et al, 2015. According to US National Library of Medicine of National Institute of Health (NIH), the recommended doses for humans for inability to sleep (insomnia) are 400 to 900 mg of valerian extract up to 2 h before bedtime for as long as 28 days.…”

Section: Introductionmentioning

confidence: 99%

Abnormality of spermatozoa in Wistar rats exposed to high doses of Valeriana officinalis L. aqueous suspension

Marques¹,

BrandÃ£o²,

Oshio³

et al. 2016

J. Med. Plants Res.

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Valerian (Valeriana officinalis L.) is a natural anxiolytic widely used in traditional medicine. However reproductive toxic effects have been demonstrated in mice treated with this species. This study evaluated the effect of valerian aqueous suspension on the reproductive system of Wistar rats treated for 53 days. Four groups were studied (n=25): control (1 ml of distilled water) and treated (500, 1000 or 2000 mg/kg) with the aqueous suspension per os/day. On the 54th day, 15 rats/group were killed and the following parameters were assessed: weight of reproductive organs, liver, kidneys and spleen; serum testosterone level, sperm morphology and concentration; testicle and epididymis histomorphometry. Ten other animals/group was analyzed using the dominant lethal test. There were not significant differences in body weight, hematological and biochemical parameters, weights of the liver, kidneys, spleen, reproductive organs and accessory glands between control and treated animals. The treatment with valerian did not alter the tubular and luminal diameters of the seminiferous tubules, the serum testosterone levels and the sperm viability. The sperm concentration in the epididymis cauda was not altered by the treatment although a significant increase in the number of abnormal gametes was observed in the valerian-treated animals at all dose levels when compared to control values. Significant reduction (p<0.05) in the height of the epididymal epithelium and a significant increase in the number of abnormal gametes were observed in the animals treated with the extract at 1000 and 2000 mg/kg.

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The anxiolytic effects of a Valerian extract is based on Valerenic acid

Cited by 57 publications

References 19 publications

GABA‐modulating phytomedicines for anxiety: A systematic review of preclinical and clinical evidence

GABA‐modulating phytomedicines for anxiety: A systematic review of preclinical and clinical evidence

Role of allopregnanolone biosynthesis in acute stress-induced anxiety-like behaviors in mice

Abnormality of spermatozoa in Wistar rats exposed to high doses of Valeriana officinalis L. aqueous suspension

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