The antiviral response triggered by the cGAS/STING pathway is subverted by the foot-and-mouth disease virus proteases
Miguel Ángel Sanz,
Miryam Polo,
Miguel Rodríguez-Pulido
et al.
Abstract:Propagation of viruses requires interaction with host factors in infected cells and repression of innate immune responses triggered by the host viral sensors. Cytosolic DNA sensing pathway of cyclic GMP-AMP synthase (cGAS) and stimulator of interferon genes (STING) is a major component of the antiviral response to DNA viruses, also known to play a relevant role in response to infection by RNA viruses, including foot-and-mouth disease virus (FMDV). Here, we provide supporting evidence of cGAS degradation in swi… Show more
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