The Antiviral Potentials of Mx Proteins

Molecular characterisation and inductive expression of a fish protein arginine methyltransferase 1 gene in response to virus infection

“…4C). In mammals, Mx expression is induced by the newly produced IFN and therefore, is thought as hallmark of IFN reproduction [47,48]. In the present study, the transcriptional up-regulation of flounder Mx suggested that an IFN response had been triggered.…”

Early Steps of the Virus Replication Cycle Are Inhibited in Prostate Cancer Cells Resistant to Oncolytic Vesicular Stomatitis Virus

“…For example, in different cell types, IFN-I treatment can affect VSV replication at the level of virus penetration (28,29), primary transcription (13,18,19,23), or virus assembly (26). While the data presented here correlate the constitutive expression of antiviral gene products in PC3 cells with the anticipated effects of a typical antiviral response (inhibition of the virus at multiple levels), they do not represent a direct link.…”

IFNs and STATs in innate immunity to microorganisms

“…Mouse lines with a wild-type allele of the type I IFN-inducible Mx gene show increased resistance compared with those with a mutated Mx, corroborating cell culture studies indicating that Mx can efficiently interfere with influenza virus replication (16). In Mx-deficient mice (including most inbred mouse lines), type I IFN and STAT1 determine the tissue tropism of influenza infection (17,18).…”