The Antiviral Effect of Baicalin on Enterovirus 71 In Vitro

Li, Xiang; Liu, Yuanyuan; Wu, Tong; Jin, Yue; Cheng, Jianpin; Wan, Changbiao; Qian, Weihe; Xing, Fei; Shi, Weifeng

doi:10.3390/v7082841

Cited by 56 publications

(44 citation statements)

References 52 publications

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“…Moreover, it was also demonstrated that baicalin reduced the expressions of FasL and caspase-3, hence inhibiting EV-A71 induced apoptosis in Rhabdomyosarcoma cells (RD). Additionally, it was identified to inhibit proinflammatory cytokines by the reduction in NF-κB p65 expression [73].…”

Section: Baicalinmentioning

confidence: 99%

Flavonoids as Antiviral Agents for Enterovirus A71 (EV-A71)

Lalani

Poh

2020

Viruses

155

101

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Flavonoids are natural biomolecules that are known to be effective antivirals. These biomolecules can act at different stages of viral infection, particularly at the molecular level to inhibit viral growth. Enterovirus A71 (EV-A71), a non-enveloped RNA virus, is one of the causative agents of hand, foot and mouth disease (HFMD), which is prevalent in Asia. Despite much effort, no clinically approved antiviral treatment is available for children suffering from HFMD. Flavonoids from plants serve as a vast reservoir of therapeutically active constituents that have been explored as potential antiviral candidates against RNA and DNA viruses. Here, we reviewed flavonoids as evidence-based natural sources of antivirals against non-picornaviruses and picornaviruses. The detailed molecular mechanisms involved in the inhibition of EV-A71 infections are discussed.

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Section: Baicalinmentioning

confidence: 99%

Flavonoids as Antiviral Agents for Enterovirus A71 (EV-A71)

Lalani

Poh

2020

Viruses

155

101

View full text Add to dashboard Cite

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“…For example, out of 22 different flavonoids, six phytochemicals (apigenin, baicalein, biochanin A, kaempferol, luteolin, naringenin) were active against the avian influenza H5N1 virus in human lung epithelial (A549) cells through inhibiting nucleoprotein production [67]. Baicalin (the glucuronide of baicalein) was also active against a wide range of viruses, including enterovirus [68], dengue virus [69], respiratory syncytial virus [70], Newcastle disease virus [71], human immunodeficiency virus [72], and hepatitis B virus [73], and different mechanisms were suggested for its antiviral actions. For example, baicalin inhibits the production of HBV, the templates for viral proteins and HBV-DNA synthesis [73], and decreases IL-6 and IL-8 production without affecting IP-10 levels, as shown in a study on avian influenza H5N1 virus [67].…”

Section: Antiviral Medicinal Plants and Phytochemicalsmentioning

confidence: 99%

Antiviral effect of phytochemicals from medicinal plants: Applications and drug delivery strategies

Ben‐Shabat

Yarmolinsky²,

Porat

et al. 2019

Drug Deliv. and Transl. Res.

272

184

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Viral infections affect three to five million patients annually. While commonly used antivirals often show limited efficacy and serious adverse effects, herbal extracts have been in use for medicinal purposes since ancient times and are known for their antiviral properties and more tolerable side effects. Thus, naturally based pharmacotherapy may be a proper alternative for treating viral diseases. With that in mind, various pharmaceutical formulations and delivery systems including micelles, nanoparticles, nanosuspensions, solid dispersions, microspheres and crystals, self-nanoemulsifying and self-microemulsifying drug delivery systems (SNEDDS and SMEDDS) have been developed and used for antiviral delivery of natural products. These diverse technologies offer effective and reliable delivery of medicinal phytochemicals. Given the challenges and possibilities of antiviral treatment, this review provides the verified data on the medicinal plants and related herbal substances with antiviral activity, as well as applied strategies for the delivery of these plant extracts and biologically active phytochemicals.

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“…7) Baicalin has various pharmacological activities, such as anti-inflammation, anti-oxidation, anti-cancer and anti-viral. [8][9][10][11] Previous study has revealed that baicalin has anti-adipogenic effect, anti-oxidation and anti-inflammatory effect in AS. 12) However, the underlying molecular mechanism of baicalin on AS is still largely unknown.…”

Section: Introductionmentioning

confidence: 99%

Baicalin Suppresses the Proliferation and Migration of Ox-LDL-VSMCs in Atherosclerosis through Upregulating miR-126-5p

Chen

Pan

Sheng

et al. 2019

Biological & Pharmaceutical Bulletin

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Atherosclerosis (AS) is a chronic inflammatory disease threatening human health, and vascular smooth muscle cells (VSMCs) are involved in AS processes. Baicalin is a flavonoid compound, which has antiatherosclerotic effect. The aim of our study was to explore the molecular mechanism of baicalin on AS. The expression of miR-126-5p was measured in peripheral blood of AS patients and healthy control. We found miR-126-5p expression was decreased in AS. Then, high-mobility group box 1 (HMGB1) was verified as a target of miR-126-5p and its expression was increased in AS. Similarly, miR-126-5p and HMGB1 expression was downregulated and upregulated in oxidized low-density lipoprotein treated VSMCs (ox-LDL-VSMCs), respectively. Furthermore, baicalin upregulated miR-126-5p and downregulated HMGB1 expression. Functionally, baicalin significantly inhibited ox-LDL-VSMCs proliferation and migration, and miR-126-5p targets HMGB1 to enhance the inhibition induced by baicalin. Taken together, baicalin is able to prevent AS, which suppressed the proliferation and migration of ox-LDL-VSMCs through upregulating miR-126-5p by targeting HMGB1. These findings suggested that baicalin is an effective drug to alleviate AS, and miR-126-5p is a novel therapeutic target for AS.

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The Antiviral Effect of Baicalin on Enterovirus 71 In Vitro

Cited by 56 publications

References 52 publications

Flavonoids as Antiviral Agents for Enterovirus A71 (EV-A71)

Flavonoids as Antiviral Agents for Enterovirus A71 (EV-A71)

Antiviral effect of phytochemicals from medicinal plants: Applications and drug delivery strategies

Baicalin Suppresses the Proliferation and Migration of Ox-LDL-VSMCs in Atherosclerosis through Upregulating miR-126-5p

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