The antiviral activity of polysaccharides and their derivatives

Chen, Ling; Huang, Gangliang

doi:10.1016/j.ijbiomac.2018.04.056

Cited by 205 publications

(98 citation statements)

References 26 publications

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“…Several natural compounds have been investigated as potential therapies. These natural products include eucalyptus extracts [34], polysaccharides and diglycerides [35], curcumin [36], and polyphenols from tea [24] Herpes simplex virus infections continue to affect a large percentage of the human population worldwide. There is no cure for HSV-1 infections and there remains a need to identify effective and affordable therapies to reduce the incidence.…”

Section: Discussionmentioning

confidence: 99%

Inhibition of Herpes Simplex Virus-1 by the Modified Green Tea Polyphenol EGCG-Stearate

Patel¹,

Adams²,

Lee³

2018

ABB

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Epigallocatechin gallate (EGCG), a green tea polyphenol possesses antioxidant, antibacterial, anticancer and antiviral properties. EGCG-Stearate (EGCG-S) is of interest for this study because of its stability and lipophilic properties. The chemical modification of EGCG-S increased its lipid solubility. Herpes simplex virus-1 (HSV-1), a member of the family Herpesviridae, and Alphaherpesvirinae subfamily is a leading cause of human viral diseases in the United States. In this study, 25 μM, 50 μM, 75 μM, and 100 µM of EGCG and EGCG-S were used to carry out cytotoxicity, cell viability and cell proliferation assays to determine the maximum non-cytotoxic concentrations on cultured A549 cells. The results suggested that 75 µM of EGCG and EGCG-S is the appropriate concentration to further study the effect on the infection of HSV-1 in A549 cells. Infectivity, antiviral, and inverted microscopy assays were performed to study the effects of EGCG and EGCG-S on HSV-1 infection. An antiviral assay was performed using luminescence and it indicated that EGCG-S treated HSV-1 showed up to 90% inhibition. Confocal microscopy images further supported the inhibitory effects of 75 μM EGCG-S on HSV-1 infection in A549 cells. The long-term goal of this research is to use EGCG-S as a possible novel topical therapeutic treatment to limit the spread of HSV-1 infections.

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Section: Discussionmentioning

confidence: 99%

Inhibition of Herpes Simplex Virus-1 by the Modified Green Tea Polyphenol EGCG-Stearate

Patel¹,

Adams²,

Lee³

2018

ABB

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“…In addition, the most important condition that must be possessed as an antiviral drug is to inhibit the virus in the cell and have no effect on the normal metabolism of cell. At present, a large number of antiviral drugs have serious side effects, which makes it difficult to develop effective antiviral agents with little side effects [28]. Therefore, there remain important medical needs to improve upon the current therapy as well as those there exists no treatment [27].…”

Section: Lead Antiviral Molecules Obtained Via Same Mentioned Approachmentioning

confidence: 99%

Sharing via Low-Cost Discovery in Global Effort for Combat Diseases: Simple Chemical Routes for Lead Compounds Using Biomass Driven Building Blocks.

2018

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A MONG various participations in the global efforts for drugs, preservatives and pesticides discovery, there are cost-effective simple synthetic routes via productive methods to synthesize potent biologically active compounds, utilizing biomass driven starting compounds. This eco-friendly approach appropriates also researchers where shortage in research fund and facilities. Versatile precursors such as 3-oxoalkane carboxylates, activated nitriles and a,β unsaturated ketones, were utilized for the facile synthesis of various biologically interesting small molecules. In this review, we highlight representative synthetic findings for bioactive leads arising from our continuous attempts with this approach. Further development by industry and academia through lead optimization will produce new active ingredients to face contiguous hazard biological challenges and resistance of microbes and insects. Many other researchers have made many great achievements in each of these subjects, but these are beyond the scope of this review.

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“…Polysaccharides are among the major classes of bioactive substances which exist widely in plants, animals and microorganisms. Recently, polysaccharides have become one of the research hotspots of natural medicine and food processing due to their numerous health benefits, biological functions (Huang et al , ; Huang & Huang, ; Chen & Huang, ; Chen & Huang, ) and antioxidant potential (Li et al , ). Moreover, polysaccharides from natural sources are usually nontoxic, biodegradable with no adverse effects and have been widely used in the food industry to improve rheological properties, extend shelf life and encapsulate flavour compounds (Shao et al , ; Shi et al , ).…”

Section: Introductionmentioning

confidence: 99%

Optimising deproteinisation methods and effect of deproteinisation on structural and functional characteristics of flaxseed gum

Safdar

Pang

Liu

et al. 2020

Int J of Food Sci Tech

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In the current study, deproteinisation rate (DPR) and carbohydrate loss ratio (CLR) in flaxseed gum (FSG) were compared as indexes by using four different deproteinised methods, that is sodium chloride (NaCl), trichloroacetic acid (TCA), hydrochloric acid (HCl) and calcium chloride (CaCl 2 ). In addition, the effect of deproteinisation on physicochemical, functional and structural characteristics (FTIR, 1 H NMR and SEM analysis) of deproteinised flaxseed gum (DFSG) was further examined. The results revealed that HCl and TCA methods had better ability of deproteinisation (97.83% and 96.21%) but resulted in higher CLR (27.66% and 24.19%), while CaCl 2 method excelled over the NaCl method in DPR (94.7% and 88.6%) and CLR (4.90% and 4.21%), respectively. Flaxseed gum showed significant functional properties even after deproteinisation and exhibited resolved resonances for both ring and anomeric protons in 1 H NMR spectra. The characteristic groups in FTIR spectra were retained after deproteinisation.

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The antiviral activity of polysaccharides and their derivatives

Cited by 205 publications

References 26 publications

Inhibition of Herpes Simplex Virus-1 by the Modified Green Tea Polyphenol EGCG-Stearate

Inhibition of Herpes Simplex Virus-1 by the Modified Green Tea Polyphenol EGCG-Stearate

Sharing via Low-Cost Discovery in Global Effort for Combat Diseases: Simple Chemical Routes for Lead Compounds Using Biomass Driven Building Blocks.

Optimising deproteinisation methods and effect of deproteinisation on structural and functional characteristics of flaxseed gum

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