The antiviral activity of antibodies in vitro and in vivo

Parren, Paul W.H.I.; Burton, Dennis R.

doi:10.1016/s0065-2776(01)77018-6

Cited by 233 publications

(200 citation statements)

References 235 publications

(318 reference statements)

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“…In support for the second it is generally accepted that higher neutralization titers are required to block direct cell-to-cell spread than to neutralize infection by free virus (for review see ref. 19). An effect of neutralizing Abs on virus replication has been described for measles viruses, sindbis virus, rabies virus, and Friend leukemia virus infection.…”

Section: Viral Infection and Tumor Development In The Absence Of Neutmentioning

confidence: 99%

The role of neutralizing antibodies for mouse mammary tumor virus transmission and mammary cancer development

Finke

Luther²,

Acha‐Orbea³

2002

Proc. Natl. Acad. Sci. U.S.A.

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Mouse mammary tumor virus (MMTV) infection establishes chronic germinal centers and a lifelong neutralizing Ab response. We show that removal of the draining lymph node after establishment of the germinal center reaction led to complete loss of neutralizing Abs despite comparable infection levels in peripheral lymphocytes. Importantly, in the absence of neutralization, only the exocrine organs mammary gland, salivary gland, pancreas, and skin showed strikingly increased infection, resulting in accelerated mammary tumor development. Induction of stronger neutralization did not influence chronic infection levels of peripheral lymphoid organs but strongly inhibited mammary gland infection and virus transmission to the next generation. Taken together, we provide evidence that a tight equilibrium in virus neutralization allows limited infection of exocrine organs and controls cancer development in susceptible mouse strains. These experiments show that a strong neutralizing Ab response induced after infection is not able to control lymphoid MMTV infection. Strong neutralization, however, is capable of blocking amplification of mammary gland infection, tumor development, and virus transmission to the next generation. The results also indicate a role of neutralization in natural resistance to MMTV infection.

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Section: Viral Infection and Tumor Development In The Absence Of Neutmentioning

confidence: 99%

The role of neutralizing antibodies for mouse mammary tumor virus transmission and mammary cancer development

Finke

Luther²,

Acha‐Orbea³

2002

Proc. Natl. Acad. Sci. U.S.A.

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“…However, the relative importance of mobilizing each arm of the immune system and the means to induce each type of immunity are unclear. Although several successful passive immunization studies using neutralizing monoclonal antibodies in macaques strongly suggest that inducing broadly reactive neutralizing antibodies as part of any vaccine regimen would be beneficial [1][2][3][4][5], the levels and breadth of neutralizing antibodies induced by active vaccination have thus far proved insufficient to protect against infection [6][7][8]. It appears necessary that a vaccine must activate both cellular and humoral immune mechanisms.…”

Section: Introductionmentioning

confidence: 99%

Live attenuated Listeria monocytogenes expressing HIV Gag: Immunogenicity in rhesus monkeys

Jiang

Rasmussen

Nolan

et al. 2007

Vaccine

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Induction of strong cellular immunity will be important for AIDS vaccine candidates. Natural infection with wild-type Listeria monocytogenes (Lm), an orally transmitted organism, is known to generate strong cellular immunity, thus raising the possibility that live attenuated Lm could serve as a vaccine vector. We sought to examine the potential of live attenuated Lm to induce cellular immune responses to HIV Gag. Rhesus macaques were immunized with Lmdd-gag that expresses HIV gag and lacks two genes in the D-alanine (D-ala) synthesis pathway. Without this key component of the bacterial cell wall, vaccine vector replication critically depends on exogenous D-ala. Lmdd-gag was given to animals either solely orally or by oral priming followed by intramuscular (i.m.) boosting; D-ala was co-administered with all vaccinations. Lmdd-gag and D-ala were well tolerated. Oral priming/oral boosting induced Gag-specific cellular immune responses, whereas oral priming/i.m. boosting induced systemic as well as mucosal anti-Gag antibodies. These results suggest that the route of vaccination may bias anti-Gag immune responses either towards T-helper type 1 (Th1) or Th2 responses; overall, our data show that live attenuated, recombinant Lmdd-gag was safe and immunogenic in primates.

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“…N eutralizing antibody responses after natural infection or vaccination comprise a major component of protection from virus infection (1). The majority of antibodies directed against the viral envelope glycoprotein (Env) recognizes nonneutralizing epitopes of glycoprotein monomers and is ineffectual (2,3).…”

mentioning

confidence: 99%

Rapid evolution of the neutralizing antibody response to HIV type 1 infection

Richman¹,

Wrin²,

Little³

et al. 2003

Proc. Natl. Acad. Sci. U.S.A.

1,073

1,085

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A recombinant virus assay was used to characterize in detail neutralizing antibody responses directed at circulating autologous HIV in plasma. Examining serial plasma specimens in a matrix format, most patients with primary HIV infection rapidly generated significant neutralizing antibody responses to early (0 -39 months) autologous viruses, whereas responses to laboratory and heterologous primary strains were often lower and delayed. Plasma virus continually and rapidly evolved to escape neutralization, indicating that neutralizing antibody exerts a level of selective pressure that has been underappreciated based on earlier, less comprehensive characterizations. These data argue that neutralizing antibody responses account for the extensive variation in the envelope gene that is observed in the early months after primary HIV infection.

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The antiviral activity of antibodies in vitro and in vivo

Cited by 233 publications

References 235 publications

The role of neutralizing antibodies for mouse mammary tumor virus transmission and mammary cancer development

The role of neutralizing antibodies for mouse mammary tumor virus transmission and mammary cancer development

Live attenuated Listeria monocytogenes expressing HIV Gag: Immunogenicity in rhesus monkeys

Rapid evolution of the neutralizing antibody response to HIV type 1 infection

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