The Antiviral Activity of a Triazinoindole (SK&amp;F 30097)

Matsumoto, Shigehiro; Stanfield, F. J.; Goore, Moshe Y.; Haff, R. F.

doi:10.3181/00379727-139-36163

Cited by 14 publications

(7 citation statements)

References 3 publications

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“…The search for effective antirhinovirus agents has yielded a wealth of compounds belonging to widely varying chemical classes: thiosemicarbazones (20), isoquinolines (35,43), triazinoindoles (27), guanidines (5), benzoates (30), furanyls (2), benzimidazoles (12), thiourea (18), diketones (14,16,17), flavans (3,32), flavones (25), chalcones (24), nitrobenzenes (34,41), and isoxazoles (15,31). The most recently developed antirhinovirus compounds (3,15,24,31) reach their MICs within the range of 0.001 to 0.01 ,ug/ml.…”

mentioning

confidence: 99%

Antirhinovirus activity of purine nucleoside analogs

Clercq¹,

Bernaerts²,

Bergstrom³

et al. 1986

Antimicrob Agents Chemother

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A wide variety of purine nucleoside (mainly tubercidin and adenosine) analogs, which had previously been shown to inhibit the replication of a broad spectrum of RNA viruses, were evaluated for their antirhinovirus activity in human diploid (WI-38) fibroblasts. Tubercidin, 5-(l-hydroxyethyl)tubercidin, 5-(2-buten-lyl)tubercidin, toyocamycin, and sangivamycin emerged as the most potent inhibitors. These compounds inhibited the replication of rhinovirus types 1A, 1B, and 9 at an MIC well below 1 ,ug/ml. However, these compounds proved cytotoxic for the uninfected host cells at concentrations which were only slightly higher (3-to 10-fold, on the average) than those required for inhibition of rhinovirus replication. The most selective inhibitor of rhinovirus replication was 3-deazaguanine, with a selectivity index of 50. None of the carbocyclic and acyclic analogs of adenosine tested exhibited a potent or selective antirhinovirus activity.The search for effective antirhinovirus agents has yielded a wealth of compounds belonging to widely varying chemical classes: thiosemicarbazones

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confidence: 99%

Antirhinovirus activity of purine nucleoside analogs

Clercq¹,

Bernaerts²,

Bergstrom³

et al. 1986

Antimicrob Agents Chemother

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“…No virucidal effect was observed at a high compound concentration against a sensitive rhinovirus, and despite its broad antiviral spectrum, interferon induction was not demonstrated by a sensitive method of assay. SK&F 30097, a close analogue of SK&F 40491, was shown to selectively inhibit RNA synthesis of a picornavirus (8). It is likely that SK&F 40491 has a similar action.…”

mentioning

confidence: 99%

The in Vitro Antiviral Activity of a Triazinoindole (SK&F 40491)

Haff¹,

Flagg²,

Gallo³

et al. 1972

Experimental Biology and Medicine

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“…Some derivatives of thiosemicarbazones, the 3-substituted triazinoindoles (SKF 21687, SKF 30097, SKF 36800, SKF 40491) (Fig. 24), are broad-spectrum antipicornavirus agents that block several rhinovirus strains (Matsumoto et al, 1972;Pfau, 1982). SKF 40491 has antirhinovirus activity when administered intranasally to gibbons, but not when used orally (Pinto et aL, 1972).…”

Section: Thiosemicarbazonesmentioning

confidence: 99%

Picornavirus inhibitors

Carrasco

1994

Pharmacology & Therapeutics

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Picornaviruses are among the best understood animal viruses in molecular terms. A number of important human and animal pathogens are members of the Picornaviridae family. The genome organization, the different steps of picornavirus growth and numerous compounds that have been reported as inhibitors of picornavirus functions are reviewed. The picornavirus particles and several agents that interact with them have been solved at atomic resolution, leading to computer-assisted drug design. Picornavirus inhibitors are useful in aiding a better understanding of picornavirus biology. In addition, some of them are promising therapeutic agents. Clinical efficacy of agents that bind to picornavirus particles has already been demonstrated.

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The Antiviral Activity of a Triazinoindole (SK&F 30097)

Cited by 14 publications

References 3 publications

Antirhinovirus activity of purine nucleoside analogs

Antirhinovirus activity of purine nucleoside analogs

The in Vitro Antiviral Activity of a Triazinoindole (SK&F 40491)

Picornavirus inhibitors

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