The Antitumor Effect of Singlet Oxygen

Bauer, Georg

doi:10.21873/anticanres.11148

Cited by 43 publications

(39 citation statements)

References 61 publications

(107 reference statements)

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“…Analogous findings have been reported for direct inactivation of catalase by exogenous singlet oxygen (24) and by cellderived singlet oxygen after modulation of the endogenous NO concentration through the NOD inhibitor cyanidin (7,17,20). The effect of DADS requires an initial, autoamplificatory step of singlet oxygen generation and catalase inactivation, followed by intercellular ROS/RNS-dependent apoptosisinducing signaling.…”

Section: Tetrakis(4-sulfonatophenyl)porphyrinato Iron(iii) Chloride (supporting

confidence: 71%

“…Membrane-associated catalase and SOD in combination with active NOX1 have been defined as promising specific targets for novel therapeutic approaches (17)(18)(19). To understand the various modes of catalase inhibition/ inactivation and the resultant reactivation of intercellular ROS/RNS-dependent apoptosis-inducing signaling seems to be essential for the optimization of novel antitumor strategies based on reactive oxygen species/reactive nitrogen species (ROS/RNS) signaling.…”

Section: Show Sustained Expression Of Membrane-associated Nadph Oxidamentioning

confidence: 99%

“…oxygen inactivates catalase and thus reactivates intercellular apoptosis-inducing signaling (7,17,20,24). Cell-derived singlet oxygen can be generated after enhancement of the intracellular NO concentration, followed by inhibition of membrane-associated catalase.…”

Section: Small Interfering Ribonucleic Acid (Sirna)-based Analysis Ofmentioning

confidence: 99%

“…This allows for subsequent interaction between peroxynitrous acid and H 2 O 2 , leading to the formation of singlet oxygen. This process is further amplified through the FASR and caspase 8 (7,17,19,20). An ongoing study has shown that the garlic-derived compound DADS acts in an analogous mode to that of cyanidin, i.e.…”

Section: Small Interfering Ribonucleic Acid (Sirna)-based Analysis Ofmentioning

confidence: 99%

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siRNA-based Analysis of the Abrogation of the Protective Function of Membrane-associated Catalase of Tumor Cells

Bauer

2017

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Section: Tetrakis(4-sulfonatophenyl)porphyrinato Iron(iii) Chloride (supporting

confidence: 71%

Section: Show Sustained Expression Of Membrane-associated Nadph Oxidamentioning

confidence: 99%

Section: Small Interfering Ribonucleic Acid (Sirna)-based Analysis Ofmentioning

confidence: 99%

Section: Small Interfering Ribonucleic Acid (Sirna)-based Analysis Ofmentioning

confidence: 99%

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siRNA-based Analysis of the Abrogation of the Protective Function of Membrane-associated Catalase of Tumor Cells

Bauer

2017

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“…The functional complex of membrane-associated NOX1 and protective catalase and SOD represents a regular characteristic of tumor cells and therefore is a focus for the establishment of novel therapeutic approaches (18)(19)(20). The complex signaling chemistry of transformed cells, or tumor cells after inhibition of their membrane-associated catalase, has, so far, been mainly elucidated through inhibitor studies and reconstitution experiments.…”

Section: Abstract Intercellular Reactive Oxygen/reactive Nitrogen Spmentioning

confidence: 99%

Central Signaling Elements of Intercellular Reactive Oxygen/Nitrogen Species-dependent Induction of Apoptosis in Malignant Cells

Bauer

2017

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Abstract. Intercellular reactive oxygen/reactive nitrogen species-(ROS/RNS)-dependent induction of apoptosis in malignant cells is discussed as a potential control step during oncogenesis. In previous studies, the mechanism of intercellular apoptosis-inducing signaling was mainly established throughSelective induction of apoptosis in transformed cells is established either through their interaction with neighboring non-transformed cells or through autocrine apoptotic selfdestruction (1-3). Thereby, the HOCl (2, 5) and the nitric oxide/peroxynitrite (NO/PON) signaling pathways (2, 5, 6) are the dominant intercellular apoptosis-inducing signaling pathways [reviewed in (5)]. Both pathways are driven by superoxide anions which are generated by membraneassociated NADPH oxidase-1 (NOX1) of malignant cells (4, 7) and result in the generation of hydroxyl radicals that induce apoptosis through lipid peroxidation in the cell membrane (8).Mechanisms and the multiple modes of interaction of these pathways have been elucidated through inhibitor and reconstitution experiments [reviewed in (4, 5, 9)].Elimination of transformed cells through selective apoptosis induction mediated by intercellular reactive oxygen species (ROS)-dependent signaling has been discussed as a potential natural tumor-preventive mechanism (4, 10, 11). This concept is in agreement with the pioneering work of Deichman et al. , who have shown that tumor progression requires establishment of resistance to H 2 O 2 (12, 13). Resistance is achieved through the expression of membraneassociated catalase (8,14,15). Catalase interferes with the HOCl signaling pathway through decomposition of H 2 O 2 and with NO/PON signaling through oxidation of NO and decomposition of PON (5,8,16,17). Recent quantitative characterization of membrane-associated catalase has shown that localization of catalase on the outside of cells is already associated with the transformed state of the cells, however, at a concentration that is not sufficient to prevent intercellular ROS-dependent signaling (15). Catalase seems to be released by tumor cells and is covalently attached to the cells through the action of transglutaminase-2 (15).In addition to membrane-associated catalase, tumor cells also carry superoxide dismutase (SOD) on their membrane. SOD has a co-modulatory role through preventing superoxide anion-dependent inhibition of catalase (9, 18).The functional complex of membrane-associated NOX1 and protective catalase and SOD represents a regular characteristic of tumor cells and therefore is a focus for the establishment of novel therapeutic approaches (18)(19)(20). The complex signaling chemistry of transformed cells, or tumor cells after inhibition of their membrane-associated catalase, has, so far, been mainly elucidated through inhibitor studies and reconstitution experiments. Small interfering ribonucleic acid (siRNA)-based knockdown of defined 499

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Photochemically Produced Singlet Oxygen: Applications and Perspectives

2018

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This Review aims to provide early stage researchers with an updated guide to applications of photochemically produced singlet oxygen and, at the same time, widen the experienced researcher's perspectives in a holistic approach to singlet oxygen chemistry. Without being exhaustive, literature between 2010 and early 2018 has been surveyed by focusing on a critical evaluation of new knowledge and applications. After an introductory section concerning singlet oxygen production, detection, and interactions with biological systems, subsequent sections describe current applications of singlet‐oxygen‐enabled technology. Besides strictly chemical synthesis applications, attention has been given to the usage of singlet oxygen in photochemically assisted therapies as well as in environmental remediation. Additionally, the potential of expanding singlet oxygen chemistry to unexplored fields has been discussed.

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The Antitumor Effect of Singlet Oxygen

Cited by 43 publications

References 61 publications

siRNA-based Analysis of the Abrogation of the Protective Function of Membrane-associated Catalase of Tumor Cells

siRNA-based Analysis of the Abrogation of the Protective Function of Membrane-associated Catalase of Tumor Cells

Central Signaling Elements of Intercellular Reactive Oxygen/Nitrogen Species-dependent Induction of Apoptosis in Malignant Cells

Photochemically Produced Singlet Oxygen: Applications and Perspectives

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