The antistress effect of majonoside-R2, a major saponin component
of Vietnamese ginseng: Neuronal mechanisms of action

Hương, Nguyêñ Thị Thu; Matsumoto, Kinzo; Watanabe, Hiroshi

doi:10.1358/mf.1998.20.1.485634

Cited by 34 publications

(15 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Recent reports indicated that ginseng components could modulate normal sleep through GABAergic systems [40]. It could also reverse social isolation stress-induced decrease in pentobarbital sleep through GABA A receptor complex and neurosteroid function [41][42][43]. So it is possible that RGE ameliorated restraint stress-induced sleep disorder by its anti-stress effects in our study, but it might have several possible mechanisms, such as GABA and its transporter in brain, neurosteroid and its binding site on the GABA A receptor complex etc.…”

Section: Discussionmentioning

confidence: 99%

Ginseng Extract Regulates the Alterations of Sleep Architecture and EEG Power Spectra in Restraint Stressed Rats

An¹,

Eun²,

Shu³

et al. 2010

Journal of Ginseng Research

View full text Add to dashboard Cite

:The present investigation was conducted to evaluate the regulation of sleep architecture by the red ginseng water extract (RGE) in acutely and chronically restraint stressed rats. Adult rats were fitted with sleep-wake recording electrodes. Following post-surgical recovery, rats were extensively habituated for freely moving polygraphic recording conditions. Polygraphic signs of sleep-wake activities were recorded for 24 h after RGE administration and induction of stress and were analyzed to understand the regulation of sleep architecture. Acute stress decreased wakefulness and increased total sleep, non-rapid eye movement (NREM) sleep, and rapid eye movement (REM) sleep in both the daytime and nighttime recording. RGE shortened the daytime NREM and REM sleep, without changing the wakefulness and total sleep. RGE increased nighttime wakefulness, and decreased total, NREM and REM sleep. Chronic stress increased wakefulness and decreased total sleep in the daytime recording, and increased REM and decreased NREM sleep in both the day and night time recording. RGE ameliorated chronic stress and induced alterations of REM and NREM sleep in the day and night time sleep architecture. Acute and chronic stress could also induce alternations in cortex electroencephalogram (EEG) recording during NREM, REM sleep and wakefulness. These findings suggest that RGE may modulate the sleep behavior in acutely and chronically stressed rats and the ameliorating effect of RGE on the sleep architecture may involve in modulation of α-, θ-and δ-wave activities of the cortical EEG.

show abstract

Section: Discussionmentioning

confidence: 99%

Ginseng Extract Regulates the Alterations of Sleep Architecture and EEG Power Spectra in Restraint Stressed Rats

An¹,

Eun²,

Shu³

et al. 2010

Journal of Ginseng Research

View full text Add to dashboard Cite

show abstract

“…Mêmes indications pour les plantes dites « adaptogènes » comme le ginseng Panax ginseng et le ginseng de Sibérie Eleutherococus senticosus, agissant de surcroît sur le stress d'origine psychologique, mais aussi sur les dépendances aux drogues dures grâce à leurs saponosides (ginsénosides, majonosides, eleuthérosides) actifs sur les récepteurs céré-braux nicotiniques et GABA [28,46,52]. Retenons que les facteurs limitants d'utilisation du ginseng dans un sevrage au tabac sont sa propension à élever la tension artérielle et la stimulation de l'appétit.…”

Section: Mé Thodes De Sevrage éValué Es Et Validé Es Quelle Efficaciunclassified

The value of medicinal plants in smoking cessation

Gigon

2008

Phytothérapie

View full text Add to dashboard Cite

“…21) The other chemicals used in this study were obtained from the following commercial sources: albumin, Griess reagent, and glutathione reductase (Sigma Chem., St. Louis, MO, U.S.A.); 2-thiobarbituric acid, malondialdehyde, b-NADPH, EDTA, glutathione (GSH), 5,5Ј-dithiobis-(2-nitrobenzoic acid) (Wako Pure Chem., Osaka, Japan); Biuret solution (Nacalai Tesque., Kyoto, Japan).…”

Section: Animalsmentioning

confidence: 99%

Social Isolation Stress-Induced Oxidative Damage in Mouse Brain and Its Modulation by Majonoside-R2, a Vietnamese Ginseng Saponin

Hương

Murakami

Tohda

et al. 2005

Biological & Pharmaceutical Bulletin

View full text Add to dashboard Cite

Lipid peroxidation induced by oxidative stress is a consequence of the production of excess free radicals, such as reactive oxygen species, and provides marked damage to the structure and function of cell membranes in various tissues.1,2) Particularly, the brain is susceptible to free radical insults because it contains a high concentration of easily peroxidizable polyunsaturated fatty acids, and is not particularly enriched in protective antioxidant enzymes or other antioxidant compounds.

show abstract

The antistress effect of majonoside-R2, a major saponin component of Vietnamese ginseng: Neuronal mechanisms of action

Cited by 34 publications

References 0 publications

Ginseng Extract Regulates the Alterations of Sleep Architecture and EEG Power Spectra in Restraint Stressed Rats

Ginseng Extract Regulates the Alterations of Sleep Architecture and EEG Power Spectra in Restraint Stressed Rats

The value of medicinal plants in smoking cessation

Social Isolation Stress-Induced Oxidative Damage in Mouse Brain and Its Modulation by Majonoside-R2, a Vietnamese Ginseng Saponin

Contact Info

Product

Resources

About