The Antiriboflavin Effect of Galactoflavin

Emerson, Gladys A.; Wurtz, Elizabeth; Johnson, Oscar H.

doi:10.1016/s0021-9258(18)43108-0

Cited by 25 publications

(3 citation statements)

References 3 publications

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“…(5) A quite different picture emerges on oxidation of L-cysteinyl.ocysteine or D-cysteinyl-L-cysteine at these two pH values. 4 The corre spending peptides of cystine, except for their optical enantiomorphism, appeared to be identical, and independent of the ¿H at which they were formed. They crystallized from water with no evidence of water of crystallization, yielded a single ninhydrin spot on the paper chromatogram with Rt * 0.16 (phenol) for each, and on HC1 hydrolysis gave good yields of DL-cystine.…”

Section: Resultsmentioning

confidence: 95%

“…Preparation of Peptides.-The peptides of L-cystine were prepared substantially as described in part I of this series. 4 Both benzyl groups of S-benzyl-L-cysteinyl-L-cysteine were removed by reduction using sodium in liquid ammonia, and the resulting L-cysteinyl-L-cysteine purified as the insoluble mercury mercaptide. Decomposition of the mercury derivative was effected with hydrogen sulfide, and, after filtration from mercury sulfide, the solution was freed from excess hydrogen sulfide by evaporation in vacuo.…”

Section: Methodsmentioning

confidence: 99%

“…Four preparations of L-cystinyl-L-cystine obtained by oxidation of L-cysteinyl-L-cysteine at pH 8.5 possessed [<t]2sd values, respectively, of -58.7°, -56.2°, -52.7°, and -46.0°( all at c 1, 1 N HC1). 4 Each of the four preparations showed two ninhydrin spots on the paper chromatogram (phenol), one a major spot with R¡ = 0.18, the other a relatively minor spot with R¡ = 0.49. The intensity of the latter spot varied inversely with the magnitude of the [ ] values of the preparations.…”

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confidence: 96%

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Studies on Polycysteine Peptides and Proteins. III. Configurations of the Peptides of L-Cystine Obtained by Oxidation of L-Cysteinyl-L-cysteine

Wade¹,

Winitz²,

Greenstein³

1956

J. Am. Chem. Soc.

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Section: Resultsmentioning

confidence: 95%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 96%

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Studies on Polycysteine Peptides and Proteins. III. Configurations of the Peptides of L-Cystine Obtained by Oxidation of L-Cysteinyl-L-cysteine

Wade¹,

Winitz²,

Greenstein³

1956

J. Am. Chem. Soc.

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Iso‐alloxazinderivate als Antagonisten des Riboflavins

Euler¹,

Karrer²

1946

Helvetica Chimica Acta

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6,7-Dichlor-9-(d,l'-ribityl)-iso-alloxazin ist von R. Kuhn, P. Weygand und E. P. MolIe+) als Antagonist des Riboflavins (Lactoflavins) angesprochen worden, indem es die Wirkung des genannten Vitamins herabsetzt oder aufhebt. I n Veroffentlichungen aus den letzten zwei Jahren, die uns erst heute bekannt werden, machten amerikanische Forscher 2) weitere Iso-alloxazinverbindungen namhaft, welche die Wirkung von suboptimalen Dosen von Riboflavin herabsetzen konnen; solche Stoffe sind 5,6-Dimethyl-9-(d, 1'-ribity1)-iso-alloxazin, 6,7-Dimethyl-10-(d, 1'-ribity1)-iso-alloxazin, das Phenazin-Analoge des Riboflavins und 6, T-Dimethyl-g-(d, 1 '-dulcity1)-iso-alloxazin.

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Studies of the development of congenital anomalies in embryos of riboflavin‐deficient, galactoflavin fed rats. I. Growth and embryologic pathology

et al. 1968

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Embryos from maternal rats maintained on a riboflavin‐deficient, galactoflavin‐augmented diet were compared by gross and histologic examinations with normal controls. On day 11 of gestation no differences were noted between control and treated embryos; on days 12 and 13 the treated embryos were smaller in overall size; and on day 14 the rate of differentiation of tissues of the treated embryos was delayed. The embryonic mortality occurred between day 11 and day 15. Serial sections of day‐14 treated embryos consistently contained extensive areas of necrosis in the mesoblast of the extremities and first branchial arch. A less frequent but similar lesion was found in the central nervous systems in two of four treated embryos examined on day 14. The pathologic lesion resembles the normal cell death which is part of the sculpturing process of developing extremities, but was of much greater magnitude. In addition, studies of sections of the extremities of the treated day‐14 embryos demonstrated a reduction in the number of cellular mitoses. By day 15 the necrosis had disappeared, the mode of clearing presumably being due to macrophage action as evidenced by photographs and by the presence of acid phosphatase‐containing cells in the areas of phagocytosis. In the early stages of mesenchymal condensation the treated specimens evidenced digital fusion but measurements of the relative total volume of mesenchyme were similar in treated and control specimens. Histochemical studies of the treated embryos but not the placentas or maternal tissues demonstrated an overall decrease in the reactions for succinic dehydrogenase from day 12 to day 17. Levels of malic and lactic dehydrogenases and alkaline and acid phosphatases were not decreased in the treated embryos when measured histochemically.

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The Antiriboflavin Effect of Galactoflavin

Cited by 25 publications

References 3 publications

Studies on Polycysteine Peptides and Proteins. III. Configurations of the Peptides of L-Cystine Obtained by Oxidation of L-Cysteinyl-L-cysteine

Studies on Polycysteine Peptides and Proteins. III. Configurations of the Peptides of L-Cystine Obtained by Oxidation of L-Cysteinyl-L-cysteine

Iso‐alloxazinderivate als Antagonisten des Riboflavins

Studies of the development of congenital anomalies in embryos of riboflavin‐deficient, galactoflavin fed rats. I. Growth and embryologic pathology

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