The antiproliferative effect of C2-ceramide on lung cancer cells through apoptosis by inhibiting Akt and NFκB

Lin, I‐Ling; Chou, Han-Lin; Lee, Jin‐Ching; Chen, Feng-Wei; Fong, Y.; Chang, Wei‐Chiao; Huang, Hurng Wern; Wu, Chang‐Yi; Wang, Hui‐Min David; Chiu, Chien‐Chih

doi:10.1186/1475-2867-14-1

Cited by 72 publications

(53 citation statements)

References 34 publications

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“…Recently, it has been shown that up-regulation of Ku70 expression in renal carcinoma cell line (786-O) could inhibit cell apoptosis and reduce susceptibility to radiation. Conversely, deletion of Ku70 induces cell apoptosis and significantly enhanced the sensitivity to radiation [ 283 ]. These observations suggest that Ku70/Ku80 may be a potential target for inhibition in cancer therapy in the future, although to date, specific inhibitors against Ku70/Ku80 have not been identified.…”

Section: The Non-homologous End-joining (Nhej) Proteinsmentioning

confidence: 99%

DNA Damage Signalling and Repair Inhibitors: The Long-Sought-After Achilles’ Heel of Cancer

et al. 2015

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For decades, radiotherapy and chemotherapy were the two only approaches exploiting DNA repair processes to fight against cancer. Nowadays, cancer therapeutics can be a major challenge when it comes to seeking personalized targeted medicine that is both effective and selective to the malignancy. Over the last decade, the discovery of new targeted therapies against DNA damage signalling and repair has offered the possibility of therapeutic improvements in oncology. In this review, we summarize the current knowledge of DNA damage signalling and repair inhibitors, their molecular and cellular effects, and future therapeutic use.

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Section: The Non-homologous End-joining (Nhej) Proteinsmentioning

confidence: 99%

DNA Damage Signalling and Repair Inhibitors: The Long-Sought-After Achilles’ Heel of Cancer

et al. 2015

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“…Hsa-miR-433 is down-regulated and is a target of tumor associated proteins GRB2 and RAB-94 in gastric cancer [54]. Hsa-miR-574 is involved in the suppression of colorectal cancer liver metastasis by negatively regulating the metastasis associated in colon cancer [55]. The lone member of the top-10 miRNA not previously associated with cancer types or diseases is hsa-miR-587.…”

Section: Resultsmentioning

confidence: 99%

Estimating survival time of patients with glioblastoma multiforme and characterization of the identified microRNA signatures

Sathipati

Huang

2016

BMC Genomics

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BackgroundThough glioblastoma multiforme (GBM) is the most frequently occurring brain malignancy in adults, clinical treatment still faces challenges due to poor prognoses and tumor relapses. Recently, microRNAs (miRNAs) have been extensively used with the aim of developing accurate molecular therapies, because of their emerging role in the regulation of cancer-related genes. This work aims to identify the miRNA signatures related to survival of GBM patients for developing molecular therapies.ResultsThis work proposes a support vector regression (SVR)-based estimator, called SVR-GBM, to estimate the survival time in patients with GBM using their miRNA expression profiles. SVR-GBM identified 24 out of 470 miRNAs that were significantly associated with survival of GBM patients. SVR-GBM had a mean absolute error of 0.63 years and a correlation coefficient of 0.76 between the real and predicted survival time. The 10 top-ranked miRNAs according to prediction contribution are as follows: hsa-miR-222, hsa-miR-345, hsa-miR-587, hsa-miR-526a, hsa-miR-335, hsa-miR-122, hsa-miR-24, hsa-miR-433, hsa-miR-574 and hsa-miR-320. Biological analysis using the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway on the identified miRNAs revealed their influence in GBM cancer.ConclusionThe proposed SVR-GBM using an optimal feature selection algorithm and an optimized SVR to identify the 24 miRNA signatures associated with survival of GBM patients. These miRNA signatures are helpful to uncover the individual role of miRNAs in GBM prognosis and develop miRNA-based therapies.Electronic supplementary materialThe online version of this article (doi:10.1186/s12864-016-3321-y) contains supplementary material, which is available to authorized users.

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“…Fomepizole is indicated for treating methanol poisoning or used when the ingestion of ethylene glycol is suspected [33]. This drug acts as an inhibitor of alcohol dehydrogenase 1B, present in human metabolism [34]. In this target, fomepizole inhibits the oxidation of ethanol to acetaldehyde (DrugBank data).…”

Section: Discussionmentioning

confidence: 99%

In silico Repositioning of Approved Drugs Against Schistosoma mansoni Energy Metabolism Targets

Silva

Bezerra

Santos

et al. 2018

Preprint

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16Schistosomiasis is a neglected parasitosis caused by Schistosoma spp. Praziquantel is used for 17 the chemoprophylaxis and treatment of this disease. Although this monotherapy is effective, the risk 18 of resistance and its low efficiency against immature worms compromises its effectiveness. 19 Therefore, it is necessary to develop new schistosomicide drugs. However, the development of new 20 drugs is a long and expensive process. The repositioning of approved drugs has been proposed as a 21 quick, cheap, and effective alternative to solve this problem. This study employs chemogenomic 22 analysis with use of bioinformatics tools to search, identify, and analyze data on approved drugs with 23 the potential to inhibit Schistosoma mansoni energy metabolism enzymes. The TDR Targets 24 Database, Gene DB, Protein, DrugBank, Therapeutic Targets Database (TTD), Promiscuous, and 2 25PubMed databases were used. Fifty-nine target proteins were identified, of which 18 had one or more 26 approved drugs. The results identified 20 potential drugs for schistosomiasis treatment, all approved 27 for use in humans. 28 29 30 31 65 In this study, the following open access databases were used: TDR Targets Database, Gene 66 DB, Protein, Therapeutic Targets Database (TTD), DrugBank, Promiscuous, and PubMed. These 67 databases complement each other to provide information on the profiles of hundreds of molecular 68 targets and approved drugs, including data about pharmacology, toxicity, pharmacogenomics, and 69 clinical screenings. Using this information, the identification of S. mansoni energy metabolism-70 inhibiting enzymes was possible, to enable the in silico repositioning of approved drugs for use in 71 anti-schistosomiasis therapy.72 73 74 75 4 76 Materials and methods 77 78 The methodology utilized is an adaptation of the methodology used by Bispo et al. [23] and 79 Silva et al. [24]. 80 81 Identification of Schistosoma mansoni energy metabolism targets 82 83 The initial target screening was performed using the TDR Targets Database version 5.0 (Fig 84 1a) (http://tdrtargets.org/) [25]. On the initial page, the "Targets" option was selected. Next, in the 85 "Select pathogen species of interest" field, the Schistosoma mansoni option was selected as the 86 species of interest. The filters field contained the following information: Name/Annotation, Features, 87 Structures, Expression, Antigenicity, Phylogenetic distribution, Essentiality, Validation data, 88Druggability, Assayability, and Bibliographic references. The number of filters was limited to 89 increase the chances of getting results. For this reason, the only expanded filter was 90 "Name/Annotation," and the "Energy metabolism" option was selected in the "KEGG high-level 91 pathway" field. Finally, the "Search" option was selected. The database returned a table containing 92 the identity (ID) of each gene of interest. 93After the genes of interest list was produced, the ID of each gene was used to obtain the 94 targets' peptide sequences form the Gene DB version 2.5 dat...

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The antiproliferative effect of C2-ceramide on lung cancer cells through apoptosis by inhibiting Akt and NFκB

Cited by 72 publications

References 34 publications

DNA Damage Signalling and Repair Inhibitors: The Long-Sought-After Achilles’ Heel of Cancer

DNA Damage Signalling and Repair Inhibitors: The Long-Sought-After Achilles’ Heel of Cancer

Estimating survival time of patients with glioblastoma multiforme and characterization of the identified microRNA signatures

In silico Repositioning of Approved Drugs Against Schistosoma mansoni Energy Metabolism Targets

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