The antiproliferative and antioxidant activities of the essential oils of<i> Juniperus</i> species from Turkey

Yağlıoğlu, Ayşe Şahin; Eser, Ferda; Yağlıoğlu, Muhammet Şamil; Demirtaş, İbrahim

doi:10.1002/ffj.3586

Cited by 19 publications

(19 citation statements)

References 47 publications

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“…J. communis is one of the most studied Juniperus species, and our data confirmed the relatively high content of α-pinene in the leaf oil of J. communis [51,52,54,55]. In addition, J. communis cone oil contained a high amount of myrcene (53.2%), which is consistent with previous reports on essential oils from J. communis collected in Poland [52] (Table 2).…”

Section: Essential Oil Compositionsupporting

confidence: 92%

Innate Immunomodulatory Activity of Cedrol, a Component of Essential Oils Isolated from Juniperus Species

et al. 2021

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Little is known about the immunomodulatory activity of essential oils isolated from Juniperus species. Thus, we isolated essential oils from the cones and leaves of eight juniper species found in Montana and in Kazakhstan, including J. horizontalis, J. scopolorum, J. communis, J. seravschanica, J. sabina, J. pseudosabina, J. pseudosabina subsp. turkestanica, and J. sibirica. We report here the chemical composition and innate immunomodulatory activity of these essential oils. Compositional analysis of the 16 samples of Juniper essential oils revealed similarities and differences between our analyses and those previously reported for essential oils from this species. Our studies represent the first analysis of essential oils isolated from the cones of four of these Juniper species. Several essential oil samples contained high levels of cedrol, which was fairly unique to three Juniper species from Kazakhstan. We found that these essential oils and pure (+)-cedrol induced intracellular Ca2+ mobilization in human neutrophils. Furthermore, pretreatment of human neutrophils and N-formyl peptide receptor 1 and 2 (FPR1 and FPR2) transfected HL60 cells with these essential oils or (+)-cedrol inhibited agonist-induced Ca2+ mobilization, suggesting these responses were desensitized by this pretreatment. In support of this conclusion, pretreatment with essential oils from J. seravschanica cones (containing 16.8% cedrol) or pure (+)-cedrol inhibited human neutrophil chemotaxis to N-formyl peptide. Finally, reverse pharmacophore mapping predicted several potential kinase targets for cedrol. Thus, our studies have identified cedrol as a novel neutrophil agonist that can desensitize cells to subsequent stimulation by N-formyl peptide.

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Section: Essential Oil Compositionsupporting

confidence: 92%

Innate Immunomodulatory Activity of Cedrol, a Component of Essential Oils Isolated from Juniperus Species

et al. 2021

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“…A review of the previous reports on the chemical composition of J. excelsa EO showed significant differences in its EO composition (Table 1). For example, α-pinene was predominant in samples from Tbilisi, Georgia (40%) [33], Iran (68% [34,48,49] and 66.4%) [35], Pakistan (64%) [44], Lebanon (86.8%) [55], Turkey (29.7-34.0%, 46.1%) [45,47]; limonene (23%) and α-terpinene (24%) in samples from Oman [36,50]; cedrol (37%) in samples collected between Greece and Albania [37]; and β-terpinyl acetate (38.0%) in samples from Turkey [56] (Table 1). In a study on two populations in the Republic of North Macedonia, Sela et al [32] reported that there were two chemotypes of J. excelsa EO: the pinene-and sabinene-chemotype.…”

Section: Juniperus Excelsamentioning

confidence: 99%

Essential Oil Composition and Bioactivity of Two Juniper Species from Bulgaria and Slovakia

et al. 2021

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Juniperus excelsa M. Bieb and J. sabina L. contain essential oil (EO), while J. sabina also contains podophyllotoxin, which is used as a precursor for anti-cancer drugs. Two studies were conducted. The first assessed the variability in the EO profile and podophyllotoxin concentration of the two junipers, depending on the location and tree gender. The main EO constituents of J. excelsa were α-cedrol, α-limonene and α-pinene, while the constituents in J. sabina were sabinene, terpinen-4-ol, myrtenyl acetate and α-cadinol. The podophyllotoxin yield of 18 J. sabina accessions was 0.07–0.32% (w/w), but this was not found in any of the J. excelsa accessions. The second study assessed the effect of hydrodistillation (Clevenger apparatus) and steam distillation (in a semi-commercial apparatus) on the EO profile and bioactivity. The extraction type did not significantly alter the EO composition. The EO profiles of the two junipers and their accessions were different and may be of interest to the industry utilizing juniper leaf EO. Breeding and selection programs could be developed with the two junipers (protected species) in order to identify chemotypes with (1) a high EO content and desirable composition, and (2) a high concentration of podophyllotoxin in J. sabina. Such chemotypes could be established as agricultural crops for the commercial production of podophyllotoxin and EO.

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“…In another study on JFFEO, Adam collected fruit samples from Greece and reported sabinene, α-thujone, and terpinen-4-ol to be the main components [46], whereas samples collected at three locations in Turkey had significantly different components. In samples collected from Amasya, a city in northern Turkey, it was reported that the main components of JFLEO were α-pinene and cedrol and the main component of JFLEO was α-pinene [34]. Samples from Eskisehir Province (central Anatolia, Turkey) studied showed that cedrol and β-thujone were the main components in JFLEO, and that sabinene and limonene were the main components in JFFEO [33].…”

Section: Gc-ms Analysismentioning

confidence: 98%

“…Although J. foetidissima EOs have been investigated in different countries and regions of the same country, they continue to be of interest for both industrial and research purposes. Table 3 summarizes data from literature reports on the main components identified in J. foetidissima EOs obtained from the leaves, fruit, branches, and wood [33,34,36,37,[46][47][48][49][50]. The chemical composition of JFFEO from the Arasbaran forest in Iran showed significant quantitative and qualitative differences [36,41,47] Although J. foetidissima EOs have been investigated in different countries and regions of the same country, they continue to be of interest for both industrial and research pur-poses.…”

Section: Gc-ms Analysismentioning

confidence: 99%

“…The chemical composition of JFFEO from the Arasbaran forest in Iran showed significant quantitative and qualitative differences [36,41,47] Although J. foetidissima EOs have been investigated in different countries and regions of the same country, they continue to be of interest for both industrial and research pur-poses. Table 3 summarizes data from literature reports on the main components identified in J. foetidissima EOs obtained from the leaves, fruit, branches, and wood [33,34,36,37,[46][47][48][49][50]. The chemical composition of JFFEO from the Arasbaran forest in Iran showed significant quantitative and qualitative differences [36,41,47]; sabinene, α-pinene, and limonene were the main components, but all three were present in different percentages.…”

Section: Gc-ms Analysismentioning

confidence: 99%

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Chemical Composition of Essential Oils from Leaves and Fruits of Juniperus foetidissima and Their Attractancy and Toxicity to Two Economically Important Tephritid Fruit Fly Species, Ceratitis capitata and Anastrepha suspensa

et al. 2021

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The present study analyzed the chemical composition of Juniperus foetidissima Willd. essential oils (EOs) and evaluated their attractancy and toxicity to two agriculturally important tephritid fruit flies. The composition of hydrodistilled EOs obtained from leaves (JFLEO) and fruits (JFFEO) of J. foetidissima was analyzed by GC–FID and GC–MS. The main compounds were α-pinene (45%) and cedrol (18%) in the JFLEO and α-pinene (42%), α-thujone (12%), and β-thujone (25%) in the JFFEO. In behavioral bioassays of the male Mediterranean fruit fly, Ceratitis capitata (Wiedemann), both JFLEO and JFFEO showed strong attraction comparable to that observed with two positive controls, Melaleuca alternifolia and Tetradenia riparia EOs. In topical bioassays of the female Caribbean fruit fly, Anastrepha suspensa (Loew), the toxicity of JFFEO was two-fold higher than that of JFLEO, with the LD50 values being 10.46 and 22.07 µg/µL, respectively. This could be due to differences in chemical components between JFLEO and JFFEO. The JFFEO was dominated by 48% monoterpene hydrocarbons (MH) and 46% oxygenated monoterpenes (OM), while JFLEO consisted of 57% MH, 18% OM, and 20% oxygenated sesquiterpenes (OS). This is the first study to evaluate the attractancy and toxicity of J. foetidissima EOs to tephritid fruit flies. Our results indicate that JFFEO has the potential for application to the management of pest tephritid species, and further investigation is warranted.

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The antiproliferative and antioxidant activities of the essential oils of Juniperus species from Turkey

Cited by 19 publications

References 47 publications

Innate Immunomodulatory Activity of Cedrol, a Component of Essential Oils Isolated from Juniperus Species

Innate Immunomodulatory Activity of Cedrol, a Component of Essential Oils Isolated from Juniperus Species

Essential Oil Composition and Bioactivity of Two Juniper Species from Bulgaria and Slovakia

Chemical Composition of Essential Oils from Leaves and Fruits of Juniperus foetidissima and Their Attractancy and Toxicity to Two Economically Important Tephritid Fruit Fly Species, Ceratitis capitata and Anastrepha suspensa

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