The antiparasitic activity of avenacosides against intestinal nematodes

Doligalska, Maria; Jóźwicka, Kinga; Donskow‐Łysoniewska, Katarzyna; Kalinowska, Małgorzata

doi:10.1016/j.vetpar.2017.05.003

Cited by 12 publications

(7 citation statements)

References 52 publications

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“…A more sustainable plant source than those referred to above is oats ( Avena sativa ); the saponins avenacosides A and B (Fig. 7) were extracted from seedlings using methanol [96]. The authors also sought to emulate the plant response to fungal infection by treating the saponins with avenacosidase, a β-glucosidase that produces the 26-desglucosyl form of the compounds.…”

Section: Chemical Classes Of Natural Compounds Described As Anthelminmentioning

confidence: 99%

“…Given the use of oats as a traditional remedy for humans and cattle, avenacoside B and its 26-desglucosyl form were each tested against fungi, as well as against eggs and larvae of the parasitic nematode Heligmosomoides bakeri . Although growth of the fungus Trichoderma harzianum was inhibited in vitro , anthelmintic activity was apparently confounded by the presence of 2% ethanol in the preparations, which claimed much of the effect observed relative to medium-only controls in most tests, perhaps with the exception of Rho-123 dye accumulation, which would indicate an interference with a P-glycoprotein-type efflux pump [96].…”

Section: Chemical Classes Of Natural Compounds Described As Anthelminmentioning

confidence: 99%

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An appraisal of natural products active against parasitic nematodes of animals

Garcia-Bustos

Sleebs

2019

Parasites Vectors

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Here, the scientific and patent literature on the activities of purified natural compounds has been reviewed, with the aim of assessing their suitability as anthelmintic drug discovery starting points. Only compounds described as active against parasitic nematodes of animals or against the model nematode Caenorhabditis elegans have been analysed. Scientific articles published since 2010 and patents granted from 2000, both inclusive, have been included in this analysis. The results show a scarcity of novel chemical structures, a limited follow-up of compounds disclosed before 2010 and a bias towards the screening of plant products, almost to the exclusion of other sources, when microbial extracts have, historically, provided most starting points for anti-infective drugs. All plant products published in this period were previously known, alerting to the high re-discovery rates of a limited number of chemical classes from this source. The most promising compounds described in the literature reviewed here, namely the linear nemadectin-derivatives, are novel and of bacterial origin. Patented but otherwise unpublished spiroketal structures also appear as interesting scaffolds for future development. The patent literature confirmed that it is possible to patent derivatives of previously known products, making them valid starting points for translational research.

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Section: Chemical Classes Of Natural Compounds Described As Anthelminmentioning

confidence: 99%

Section: Chemical Classes Of Natural Compounds Described As Anthelminmentioning

confidence: 99%

An appraisal of natural products active against parasitic nematodes of animals

Garcia-Bustos

Sleebs

2019

Parasites Vectors

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“…Avenacoside B, an oat saponin purified from Avena sativa green leaves, reduced the infectivity of Heligmosomoides bakeri larvae in a mouse model. Avenacoside B induced morphological changes in larvae, enhanced IL-4 production and blocked glycoprotein pump (Pgp) activity [79].…”

Section: Natural Products Active Against Intestinal Parasitic Nematodesmentioning

confidence: 99%

Plant-Based Natural Products for the Discovery and Development of Novel Anthelmintics against Nematodes

2020

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Intestinal parasitic nematodes infect approximately two billion people worldwide. In the absence of vaccines for human intestinal nematodes, control of infections currently relies mainly on chemotherapy, but resistance is an increasing problem. Thus, there is an urgent need for the discovery and development of new anthelmintic drugs, especially ones with novel mechanisms of action. Medicinal plants hold great promise as a source of effective treatments, including anthelmintic therapy. They have been used traditionally for centuries and are mostly safe (if not, their toxicity is well-known). However, in most medicinal plants the compounds active against nematodes have not been identified thus far. The free-living nematode C. elegans was demonstrated to be an excellent model system for the discovery of new anthelmintics and for characterizing their mechanism of action or resistance. The compounds discussed in this review are of botanical origin and were published since 2002. Most of them need further studies of their toxicity, mechanisms and structure-activity relationship to assess more fully their potential as drugs.

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“…plant cysteine proteinases, flavonoids and condensed tannins, have been confirmed in vitro and in vivo in small ruminants and cattle and more than 850 papers were published on the use of natural compounds the last 20 years. Klongsiriwet et al (2015) showed the first evidence of synergistic effects between condensed tannins and two common flavonoids, quercetin and luteolin, in terms of inhibiting the in vitro ex-sheathment of H. contortus L3s and recently Doligalskaa et al (2017) indicated that Avena sative -originated saponins may represent an inexpensive source of anti-parasite natural products. These findings suggest that opportunities should be investigated for increasing anthelmintic activity by mixing plant materials that contain condensed tannins and quercetin or luteolin flavonoids, or to select plants with enhanced tannin and quercetin or luteolin contents.…”

Section: Anthelminticsmentioning

confidence: 99%

Control of helminth ruminant infections by 2030

Charlier²,

et al. 2018

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Helminth infections have large negative impacts on production efficiency in ruminant farming systems worldwide, and their effective management is essential if livestock production is to increase to meet future human needs for dietary protein. The control of helminths relies heavily on routine use of chemotherapeutics, but this approach is unsustainable as resistance to anthelmintic drugs is widespread and increasing. At the same time, infection patterns are being altered by changes in climate, land-use and farming practices. Future farms will need to adopt more efficient, robust and sustainable control methods, integrating ongoing scientific advances. Here, we present a vision of helminth control in farmed ruminants by 2030, bringing to bear progress in: (1) diagnostic tools, (2) innovative control approaches based on vaccines and selective breeding, (3) anthelmintics, by sustainable use of existing products and potentially new compounds, and (4) rational integration of future control practices. In this review, we identify the technical advances that we believe will place new tools in the hands of animal health decision makers in 2030, to enhance their options for control and allow them to achieve a more integrated and sustainable approach to helminth control in support of animal welfare and production.

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The antiparasitic activity of avenacosides against intestinal nematodes

Cited by 12 publications

References 52 publications

An appraisal of natural products active against parasitic nematodes of animals

An appraisal of natural products active against parasitic nematodes of animals

Plant-Based Natural Products for the Discovery and Development of Novel Anthelmintics against Nematodes

Control of helminth ruminant infections by 2030

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