The Antioxidative, Antiaging, and Hepatoprotective Effects of Alkali‐Extractable Polysaccharides by <i>Agaricus bisporus</i>

Li, Shangshang; Li, Juan; Zhang, Jianjun; Wang, Wenshuai; Wang, Xiuxiu; Jing, Huijuan; Ren, Zhenzhen; Gao, Zheng; Song, Xinling; Gong, Zaiwu

doi:10.1155/2017/7298683

Cited by 18 publications

(10 citation statements)

References 46 publications

(50 reference statements)

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“…Specifically, AcAPS-2 showed scavenging activity on hydroxyl (82.98 ± 4.67%) and DPPH (64.47 ± 4.05%) radicals at the concentration of 1.0 mg/mL in vitro [68]. Both AlAPS and AcAPS demonstrated hepatic and nephric protection activities by improving serum enzyme activity, biochemical levels, lipid contents, and antioxidant status [66,68]. ABP and fractions Abnp1002 and Abap1002 also demonstrated hepato-protective activity against CCl 4 -induced hepatic injury in mice [7,69].…”

Section: Mushroom Species Containing Bioactive Polysaccharidesmentioning

confidence: 94%

“…Table 2 lists some important macrofungi and the bioactivities of polysaccharides from experimental studies. Agaricus bisporus polysaccharides have antiaging activity, and can protect hepatic and renal functions by improving serum enzyme activities, biochemical levels, lipid contents, and antioxidant status [66,115,116]. ABP-1 and ABP-2 fractions of polysaccharides demon-strated antitumor activity by inhibiting the growth of human breast cancer MCF-7 cells and reducing the growth of murine sarcoma 180 cells implanted subcutaneously into mice [117].…”

Section: Mushroom Species Containing Bioactive Polysaccharidesmentioning

confidence: 99%

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Macrofungi as a Nutraceutical Source: Promising Bioactive Compounds and Market Value

Niego

Rapior

Thongklang

et al. 2021

JoF

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Macrofungi production and economic value have been increasing globally. The demand for macrofungi has expanded rapidly owing to their popularity among consumers, pleasant taste, and unique flavors. The presence of high quality proteins, polysaccharides, unsaturated fatty acids, minerals, triterpene sterols, and secondary metabolites makes macrofungi an important commodity. Macrofungi are well known for their ability to protect from or cure various health problems, such as immunodeficiency, cancer, inflammation, hypertension, hyperlipidemia, hypercholesterolemia, and obesity. Many studies have demonstrated their medicinal properties, supported by both in vivo and in vitro experimental studies, as well as clinical trials. Numerous bioactive compounds isolated from mushrooms, such as polysaccharides, proteins, fats, phenolic compounds, and vitamins, possess strong bioactivities. Consequently, they can be considered as an important source of nutraceuticals. Numerous edible mushrooms have been studied for their bioactivities, but only a few species have made it to the market. Many species remain to be explored. The converging trends and popularity of eastern herbal medicines, natural/organic food product preference, gut-healthy products, and positive outlook towards sports nutrition are supporting the growth in the medicinal mushroom market. The consumption of medicinal mushrooms as functional food or dietary supplement is expected to markedly increase in the future. The global medicinal mushroom market size is projected to increase by USD 13.88 billion from 2018 to 2022. The global market values of promising bioactive compounds, such as lentinan and lovastatin, are also expected to rise. With such a market growth, mushroom nutraceuticals hold to be very promising in the years to come.

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Section: Mushroom Species Containing Bioactive Polysaccharidesmentioning

confidence: 94%

Section: Mushroom Species Containing Bioactive Polysaccharidesmentioning

confidence: 99%

Macrofungi as a Nutraceutical Source: Promising Bioactive Compounds and Market Value

Niego

Rapior

Thongklang

et al. 2021

JoF

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“…The fruiting-bodies were naturally dried and pulverized into powder using a disintegrator (Shanghai, China). The FPS or SFPS was prepared referencing to the method of Li et al and Jia et al with slight modifications [47,48]. The F. velutipes powder was extracted in distilled water (1:20, w/v) at 90 °C for 4 h. After centrifugation (4000 r/min, 15 min), the supernatant was precipitated with three volumes of ethanol (95%, v/v) overnight (4 °C).…”

Section: Methodsmentioning

confidence: 99%

Characterization, Antioxidant, Anti-Aging and Organ Protective Effects of Sulfated Polysaccharides from Flammulina velutipes

Yuan

Gao

Liu³

et al. 2019

Molecules

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As an irreversible and complex degenerative physiological process, the treatment for aging seems strategically necessary, and polysaccharides play important roles against aging owing to their abundant bioactivities. In this paper, the antioxidant and anti-aging activities of Flammulina velutipes polysaccharides (FPS) and its sulfated FPS (SFPS) on d-galactose-induced aging mice were investigated. The in vitro antioxidant activities demonstrated that SFPS had strong reducing power and superior scavenging effects on 2, 2-diphenylpicrylhydrazyl (DPPH), hydroxyl radicals and the chelating activities of Fe2+. The in vivo animal experiments manifested that the SFPS showed superior antioxidant and protective abilities against the d-galactose-induced aging by increasing the antioxidant enzyme activities, decreasing lipid peroxidation, improving the inflammatory response and ameliorating the anile condition of mice. Furthermore, the structural analysis of SFPS was investigated through FT-IR, NMR, and HPLC analysis, and the results indicated that SFPS was a homogeneous heteropolysaccharide with a weight-average molecular weight of 2.81 × 103 Da. Furthermore, SFPS has also changed in characteristic functional groups and monosaccharide composition compared to FPS. These results suggested that sulfated modification could enhance the anti-oxidation, anti-aging and protective activities of F. velutipes polysaccharides, which may provide references for the development of functional foods and natural medicines.

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“…CAT can catalyze the metabolism of hydrogen peroxide, decreasing activities of gaseous oxygen and water molecules. In addition, both MDA and LPO are considered to be the end products of lipid peroxidation and are markers of oxidative stress, leading to aging [32]. In this experiment, SOD, GSH-Px, and CAT activities were markedly elevated, while the contents of MDA and LPO were markedly depressed by administration of polysaccharides, indicating AMPS, especially at the dose of 400 mg/kg/d, has potential ability against d -gal-induced aging symptoms.…”

Section: Discussionmentioning

confidence: 99%

The Antioxidant and Anti-Aging Effects of Acetylated Mycelia Polysaccharides from Pleurotus djamor

Zhao

Gao

et al. 2019

Molecules

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The present work mainly describes the preparation of acetylated mycelia polysaccharides (AMPS) from Pleurotus djamor and investigates the antioxidant and anti-aging effects in d-galactose-induced aging mice. The optimized procedure indicates the acetyl substitution degree of AMPS is 0.54 ± 0.04 under the conditions of a reaction time of 56 h, a reaction temperature of 37 °C, and 4 mL of added acetic anhydride. The in vitro analysis and in vivo animal experiments indicate that the AMPS could alleviate the aging properties by scavenging the radicals, elevating the enzyme activities, and reducing the lipid contents. As for serum levels, the AMPS can improve the serum biochemical indices and enhance immunological activity. The histopathological observations indicate that the injuries to the liver, kidney, and brain can be remitted by AMPS intervention. The characterization showed that AMPS was one kind of β-pyranose with the weight-average molecular weights of 3.61 × 105 Da and the major monosaccharides of mannose and glucose. The results suggest that AMPS can be used as a dietary supplement and functional food for the prevention of aging and age-related diseases.

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The Antioxidative, Antiaging, and Hepatoprotective Effects of Alkali‐Extractable Polysaccharides by Agaricus bisporus

Cited by 18 publications

References 46 publications

Macrofungi as a Nutraceutical Source: Promising Bioactive Compounds and Market Value

Macrofungi as a Nutraceutical Source: Promising Bioactive Compounds and Market Value

Characterization, Antioxidant, Anti-Aging and Organ Protective Effects of Sulfated Polysaccharides from Flammulina velutipes

The Antioxidant and Anti-Aging Effects of Acetylated Mycelia Polysaccharides from Pleurotus djamor

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