The antioxidant study proprieties of<i>Thymus munbyanus</i>aqueous extract and its beneficial effect on 2, 4-Dichlorophenoxyacetic acid -induced hepatic oxidative stress in albino Wistar rats

Tichati, Lazhari; Trea, Fouzia; Ouali, Kheireddine

doi:10.1080/15376516.2020.1870183

Cited by 9 publications

(14 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our experiment, the results showed a decreased total protein and albumin levels in a dose-dependent manner following CuQ exposure, suggesting that CuQ alters protein synthesis and/or metabolism in the liver. Similar changes in albumin and total protein have been reported in animals after pesticide exposure (Elzoghby et al, 2014; Tichati et al, 2021).…”

Section: Discussionsupporting

confidence: 84%

Lipid peroxidation and changes in major antioxidant markers in copper quinolate fungicide-exposed rats

Baali,

Kirane-Amrani,

Tichati

et al. 2023

Toxicol Ind Health

Self Cite

View full text Add to dashboard Cite

The present study investigated the toxic effects of sub-chronic exposure to copper quinolate (CuQ) fungicide on liver and kidney function. Twenty-four adult male Wistar rats were equally divided into a control group, and three treated groups received, respectively, by oral gavage, three increasing doses of CuQ: 47; 67.1; and 94 mg/kg b.w corresponding, respectively, LD50/100, LD50/70, and LD50/50 daily for 8 weeks. CuQ resulted in a significant increase in the serum enzymatic activity of aspartate aminotransferase (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), and the serum levels of urea, creatinine, uric acid, and malondialdehyde, along with a marked decrease in alanine aminotransferase (ALT) activity, and the contents of total protein and albumin compared to those of the control group. Furthermore, glutathione content and the enzymatic activity of superoxide dismutase (SOD), catalase (CAT), glutathione S-transferase (GST), and glutathione peroxidase (GPx) decreased significantly in a dose-dependent manner with respect to CuQ. The adverse effects of CuO were supported by the histopathological evaluations of liver and kidney tissues. Conclusively, sub-chronic CuQ exposure was shown to induce kidney and liver oxidative damage and dysfunction.

show abstract

Section: Discussionsupporting

confidence: 84%

Lipid peroxidation and changes in major antioxidant markers in copper quinolate fungicide-exposed rats

Baali,

Kirane-Amrani,

Tichati

et al. 2023

Toxicol Ind Health

Self Cite

View full text Add to dashboard Cite

show abstract

“…The beneficial antioxidant properties of the R. Alaternus aqueous extract can be attributed to the phenolic compounds present, as previously reported for various plant extracts [25]. The R. alaternus extract we used in this study had strong DPPH freeradical scavenging activity, owing to its ability to provide hydrogen atoms [23] and is considered a primary antioxidant that is able to delay or inhibit β-carotene bleaching [45]. Additionally, its reducing power is a significant indicator of its potential antioxidant activity [46].…”

Section: Discussionsupporting

confidence: 66%

Rhamnus alaternus aqueous extract enhances the capacity of system redox defence and protects hepatocytes against aluminum chloride toxicity in rats

et al. 2021

Self Cite

View full text Add to dashboard Cite

Background This study was designed to evaluate the protective effects of a Rhamnus alaternus aqueous extract (RAAE) on aluminum chloride-induced hepatotoxicity in rats. A preliminary phytochemical study and antioxidant activity tests of the extract were performed. Methods A preliminary phytochemical study and antioxidant activity tests of the extract were performed. For the in vivo study, twenty-four male rats were divided into four groups. The control group (C); the RAAE group treated with 250 mg/kg b.w RAAE; the AlCl3 group, which received 50 mg/kg b.w AlCl3; and the AlCl3/RAAE group that was treated with AlCl3 plus RAAE. Results The RAAE contains several phenolic compounds. This plant extract showed a high radical scavenging effect and high antioxidant activity. Administration of AlCl3 resulted in a significant increase in the activities of aspartate aminotransferase and alanine aminotransferase (AST, ALT), alkaline phosphatase (ALP), and lactate dehydrogenase (LDH) and significant decreases in the plasma concentrations of total proteins and albumin. Moreover, AlCl3 induced a hepatic pro-oxidant effect leading to an increase in malonaldehyde (MDA) and carbonyl protein contents, the depletion of the content of reduced glutathione (GSH) and a decrease in the antioxidant enzymatic activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx). However, RAAE supplementation with AlCl3 treatment significantly decreased the levels of MDA and carbonyl proteins and markedly restored the activities of the antioxidant enzymes. These results are supported by the improvement in liver tissue restoration. Conclusions The Rhamnus alaternus aqueous extract was shown to have effective antioxidant activity owing to its phenolic compounds protecting against AlCl3-induced liver oxidative damage.

show abstract

“…Exposure to 2,4-D also leads to the depletion of GSH levels in the liver, contributing to a decrease in antioxidant capacity [ 71 , 119 ]. This effect was observed in rats receiving doses of 5 mg/kg of Désormone Lourd (600 g/L 2,4-D) for 4 weeks, resulting in a decrease in hepatic GSH levels and the activity of SOD, CAT, GPx, and GST [ 33 ]. Toxicity studies conducted with the active ingredient in rats identified similar results, further supporting that this effect is attributed to the active ingredient [ 71 , 74 ].…”

Section: Resultsmentioning

confidence: 99%

“…Two days of treatment with 2.5 mg/L of 2,4-D also caused this effect in zebrafish larvae at 120 hpf [ 4 ]. Furthermore, different analyzed articles reported that the increase in LDH activity is accompanied by a reduction in antioxidant enzyme activity and hepatic tissue damage [ 4 , 32 , 33 , 34 ]. This reinforces the argument that oxidative stress plays a crucial role in the progression of 2,4-D-induced hepatotoxicity.…”

Section: Resultsmentioning

confidence: 99%

“…In terms of these effects, there is a growing number of studies in the literature that highlight its hepatotoxicity in different biological models (e.g., rodents and fish). The effects include liver cellular and tissue damage, the inhibition of hepatic antioxidant enzymes, lipid peroxidation (LPO), and increased seric levels of transaminases [ 32 , 33 , 34 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

2,4-D Herbicide-Induced Hepatotoxicity: Unveiling Disrupted Liver Functions and Associated Biomarkers

Martins,

Carvalho,

Maia

et al. 2024

Toxics

View full text Add to dashboard Cite

2,4-dichlorophenoxyacetic acid (2,4-D) is a widely used herbicide worldwide and is frequently found in water samples. This knowledge has prompted studies on its effects on non-target organisms, revealing significant alterations to liver structure and function. In this review, we evaluated the literature on the hepatotoxicity of 2,4-D, focusing on morphological damages, toxicity biomarkers and affected liver functions. Searches were conducted on PubMed, Web of Science and Scopus and 83 articles were selected after curation. Among these studies, 72% used in vivo models and 30% used in vitro models. Additionally, 48% used the active ingredient, and 35% used commercial formulations in exposure experiments. The most affected biomarkers were related to a decrease in antioxidant capacity through alterations in the activities of catalase, superoxide dismutase and the levels of malondialdehyde. Changes in energy metabolism, lipids, liver function, and xenobiotic metabolism were also identified. Furthermore, studies about the effects of 2,4-D in mixtures with other pesticides were found, as well as hepatoprotection trials. The reviewed data indicate the essential role of reduction in antioxidant capacity and oxidative stress in 2,4-D-induced hepatotoxicity. However, the mechanism of action of the herbicide is still not fully understood and further research in this area is necessary.

show abstract

The antioxidant study proprieties ofThymus munbyanusaqueous extract and its beneficial effect on 2, 4-Dichlorophenoxyacetic acid -induced hepatic oxidative stress in albino Wistar rats

Cited by 9 publications

References 55 publications

Lipid peroxidation and changes in major antioxidant markers in copper quinolate fungicide-exposed rats

Lipid peroxidation and changes in major antioxidant markers in copper quinolate fungicide-exposed rats

Rhamnus alaternus aqueous extract enhances the capacity of system redox defence and protects hepatocytes against aluminum chloride toxicity in rats

2,4-D Herbicide-Induced Hepatotoxicity: Unveiling Disrupted Liver Functions and Associated Biomarkers

Contact Info

Product

Resources

About