The antioxidant screening of potential materials for drugs based on 6-nitro-1,2,4-triazoloazines containing natural polyphenol fragments

Ivanova, Alla V.; Газизуллина, Е. Р.; Borisova, Marya; Дрокин, Роман А.; Gorbunov, Evgeny B.; Ulomskiy, E. N.; Русинов, В. Л.

doi:10.1007/s00216-020-02466-2

Cited by 11 publications

(24 citation statements)

References 21 publications

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“…Earlier [44][45][46], we developed approaches and potentiometric sensor systems based on non-radical and radical oxidants, which make it possible to implement ET, HAT, and the chelating metals mechanism. High degrees of correlation with independent conventional methods, the Folin assay, the DPPH assay (inhibition of the stable radical of 2,2-diphenyl-1picrylhydrazyl), the TAS (total antioxidant status) Randox, and others [44][45][46][47][48] have been shown. The measurement results were calculated by the shift or regular change in the system potential and expressed as the integral parameter of the antioxidant capacity or the antiradical capacity, respectively.…”

Section: Genista Tinctorialmentioning

confidence: 99%

“…The antioxidant capacity is the effective concentration of K 3 [Fe(CN) 6 ] reacted with an antioxidant. The AOC expressed in universal units (mol-eq/L) and was calculated by Formulas (1) and (2) [44][45][46][47][48]. The number of equivalents in the AO molecule as a rule corresponds to the number of functional antioxidant groups involved in the electron-transfer process.…”

Section: Sensor System For Determining Antioxidant Capacity (Aoc)mentioning

confidence: 99%

“…The basis for the definition of total antiradical capacity (ARC) is a regular change in the redox potential of the reaction of antioxidants with peroxyl radicals generated during the thermal decomposition of 2,2 -azobis (2-amidinopropane) dihydrochloride [46,47].…”

Section: Sensor System For Determining Antiradical Capacity (Arc)mentioning

confidence: 99%

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Antioxidant and Antiradical Properties of Some Examples of Flavonoids and Coumarins—Potentiometric Studies

et al. 2021

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A comprehensive study of a range of flavonoids and coumarins is presented in this article. The work uses an approach that evaluates the activity of these compounds by various mechanisms: the electron transfer (ET), the hydrogen atom transfer (HAT), and the mechanism of metal chelation. The studies were carried out using the methods of the cyclic voltammetry and the potentiometry. The electrochemical behavior of these compounds was studied by the method of cyclic voltammetry; the main types of voltammograms, depending on the oxidation mechanisms, were identified. Various versions of potentiometric sensor systems have been used to detect analytical signal in approaches implemented in ET, HAT and metal chelation mechanisms. The antioxidant capacity was studied by the electron-transfer mechanism. Compounds with antioxidant properties were selected; half-reaction periods for these compounds have been determined. It has been shown that electron-donating and complexing properties directly depend on the mutual arrangement of hydroxyl groups in the molecule. The antiradical ability of the compounds has been studied. It was shown that all studied compounds inhibit peroxyl radicals. Series on the change in antioxidant and antiradical properties of compounds have been compiled. There is no correlation between the results of the study of antioxidant properties obtained using sensory systems that reveal various antioxidant mechanisms. The need to use an integrated approach in the study of antioxidant properties is shown.

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Section: Genista Tinctorialmentioning

confidence: 99%

Section: Sensor System For Determining Antioxidant Capacity (Aoc)mentioning

confidence: 99%

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Antioxidant and Antiradical Properties of Some Examples of Flavonoids and Coumarins—Potentiometric Studies

et al. 2021

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“…Analytical signal in this method is the potential shift of the platinum electrode in the K 3 [Fe(CN) 6 ]/K 4 [Fe(CN) 6 ] system which is observed upon the introduction of the analyzed sample [ 83 , 84 , 85 , 86 , 87 ].…”

Section: Methods To Evaluate Integrated Antioxidant Propertiesmentioning

confidence: 99%

Study of Antioxidant Properties of Agents from the Perspective of Their Action Mechanisms

Ivanova

Газизуллина

2020

Molecules

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The creation and analysis of a large variety of existing methods for the evaluation of integrated antioxidant properties are quite relevant in connection with a range of biological mechanisms of the antioxidants (AO) action. In this work, the existing methods are correlated with mechanisms of antioxidant action. It is shown that the results obtained by various methods are mainly incomparable. This can be connected with the implementation of various mechanisms of antioxidant action in methods. The analysis of the literature data presented in this review indicates the difficulty of creating a universal method and the feasibility of using integrated approaches based on the use of several methods that implement and combine various mechanisms of the chemical conversion of antioxidants. This review describes methods for studying the chelating ability of antioxidants, except for methods based on electron and hydrogen atom transfer reactions, which are currently not widely covered in modern literature. With the description of each mechanism, special attention is paid to electrochemical methods, as the interaction of active oxygen metabolites of radical and non-radical nature with antioxidants has an electron/proton/donor-acceptor nature, which corresponds to the nature of electrochemical methods and suggests that they can be used to study the interaction.

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“…From the point of view of biological activity, these compounds exhibit antiviral [ 31 , 32 ], antiseptic [ 33 , 34 ], antioxidant [ 35 , 36 ], antitumor [ 37 ], and antiglycation activity [ 38 ]. From a synthetic point of view, the nitro groups are not only a quasi-form of the amino groups for creating azoloannelated purines [ 39 , 40 , 41 ], but they also, for example, open pathways for the modification of molecules by various nucleophiles [ 42 , 43 ].…”

Section: Introductionmentioning

confidence: 99%

Oxidative Aromatization of 4,7-Dihydro-6-nitroazolo[1,5-a]pyrimidines: Synthetic Possibilities and Limitations, Mechanism of Destruction, and the Theoretical and Experimental Substantiation

et al. 2021

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The reaction tolerance of the multicomponent process between 3-aminoazoles, 1-morpholino-2-nitroalkenes, and aldehydes was studied. The main patterns of this reaction have been established. Conditions for the oxidation of 4,7-dihydro-6-nitroazolo[1,5-a]pyrimidines were selected. Previous claims that the 4,7-dihydro-6-nitroazolo[1,5-a]pyrimidines could not be aromatised have now been refuted. Compounds with an electron-donor substituent at position seven undergo decomposition during oxidation. The phenomenon was explained based on experimental data, electro-chemical experiment, and quantum-chemical calculation. The mechanism of oxidative degradation has been proposed.

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The antioxidant screening of potential materials for drugs based on 6-nitro-1,2,4-triazoloazines containing natural polyphenol fragments

Cited by 11 publications

References 21 publications

Antioxidant and Antiradical Properties of Some Examples of Flavonoids and Coumarins—Potentiometric Studies

Antioxidant and Antiradical Properties of Some Examples of Flavonoids and Coumarins—Potentiometric Studies

Study of Antioxidant Properties of Agents from the Perspective of Their Action Mechanisms

Oxidative Aromatization of 4,7-Dihydro-6-nitroazolo[1,5-a]pyrimidines: Synthetic Possibilities and Limitations, Mechanism of Destruction, and the Theoretical and Experimental Substantiation

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