The antioxidant properties of salicylate derivatives: A possible new mechanism of anti-inflammatory activity

Borges, Rosivaldo S.; Castle, Steven L.

doi:10.1016/j.bmcl.2015.07.001

Cited by 40 publications

(26 citation statements)

References 54 publications

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“…The mixture was stirred at 450 rpm for 30 min and kept in an environment without light at room temperature. The analysis was performed using a spectrophotometer (UV-VIS Shimadzu) with each sample containing 1.0 mL of the extract at the concentration to be tested and 1.0 mL of ethanol (Borges and Castle, 2015;Malki et al, 2017). The experiment was carried out in triplicate.…”

Section: Antioxidant Activitymentioning

confidence: 99%

Larvicidal effect of hydroethanolic extract from the leaves of Acmella oleracea L. R. K. Jansen in Aedes aegypti and Culex quinquefasciatus

Araújo

Ferreira

et al. 2018

South African Journal of Botany

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Edited by J Van Staden Mosquitoes, such as Aedes aegypti and Culex quinquefasciatus, are important vectors of diseases, such as dengue fever, chikungunya fever, Zika virus, and filariasis, and these diseases are public health problems. The present study was carried out to evaluate the larvicidal activity of the hydroethanolic extract from leaves of Acmella oleracea leaves against 3rd instar larvae of the Ae. aegypti dengue vector and the Cx. quinquefasciatus filariasis vector. The hydroethanolic extract caused significant mortality in Ae. aegypti and Cx. quinquefasciatus. After 24 h of exposure to the extract, it was possible to establish the LC 50 values for the extract: 11.41 ppm for Ae. aegypti and LC 50 32.40 ppm for Cx. quinquefasciatus. The hydroethanolic extract from leaves of A. oleracea showed very low ecotoxicity suggesting that it can be used without causing environmental damage. This is the first study that shows the use of hydroethanolic extract from leaves of A. oleracea as an alternative to synthetic larvicides to eliminate larvae of Ae. aegypti and Cx. quinquefasciatus in an easy, cheap and safe way.

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Section: Antioxidant Activitymentioning

confidence: 99%

Larvicidal effect of hydroethanolic extract from the leaves of Acmella oleracea L. R. K. Jansen in Aedes aegypti and Culex quinquefasciatus

Araújo

Ferreira

et al. 2018

South African Journal of Botany

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“…The stable biomimetic AmNAH is accepted as a coenzyme in the 3HB6H-catalyzed reaction to achieve a 10 mM/h conversion to gentisate (Figure 2A), which has interesting antiinflammatory and anti-bacterial activity. [5] Using this system, we also produce 5-aminosalicylate (mesalazine, used to treat inflammatory pathologies [42] ) from 3-aminobenzoate. Nevertheless, further optimization is needed to use AmNAH efficiently with a recycling system.…”

Section: Replacing Nad(p)h With Ncbs: Challenges and Prospectsmentioning

confidence: 99%

“…These monooxygenases activate molecular oxygen through transient formation of a flavin C4a‐hydroperoxide and subsequent insertion of one oxygen atom into the substrate . From a chemical synthesis perspective, flavin‐containing hydroxylases are attractive catalysts, generating aromatic products that display anti‐cancer, anti‐inflammatory or anti‐microbial properties …”

Section: Introductionmentioning

confidence: 99%

“…[4] From a chemical synthesis perspective, flavin-containing hydroxylases are attractive catalysts, generating aromatic products that display anti-cancer, anti-inflammatory or anti-microbial properties. [5] Hydroxylases that harbor a tightly bound flavin adenine dinucleotide (FAD) are classified as group A flavoprotein monooxygenases. [3c,6] These enzymes share a similar fold and use nicotinamide adenine dinucleotide (phosphate) in its reduced form (NAD(P)H, Figure 1) as an electron donor to reduce the flavin prosthetic group (Figure 2).…”

Section: Introductionmentioning

confidence: 99%

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Flavoenzyme‐mediated Regioselective Aromatic Hydroxylation with Coenzyme Biomimetics

et al. 2020

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Regioselective aromatic hydroxylation is desirable for the production of valuable compounds. External flavin‐containing monooxygenases activate and selectively incorporate an oxygen atom in phenolic compounds through flavin reduction by the nicotinamide adenine dinucleotide coenzyme, and subsequent reaction with molecular oxygen. This study provides the proof of principle of flavoenzyme‐catalyzed selective aromatic hydroxylation with coenzyme biomimetics. The carbamoylmethyl‐substituted biomimetic in particular affords full conversion in less than two hours for the selective hydroxylation of 5 mM 3‐ and 4‐hydroxybenzoates, displaying similar rates as with NADH, achieving a 10 mM/h enzymatic conversion of the medicinal product gentisate. This biomimetic appears to generate less uncoupling of hydroxylation that typically leads to undesired hydrogen peroxide. Therefore, we show these flavoenzymes have the potential to be applied in combination with biomimetics.

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“…Living organisms have developed their own antioxidant defenses against excessive amounts of ROS. However, when their limited efficiencies cannot prevent all the oxidative damages related to environmental conditions (i.e., UV light, non-equilibrated food, and pollution), the excessive amounts of ROS cause oxidative stress, which results in many non-communicable chronic diseases, such as diabetes, atherosclerosis, arthritis, and cancer [27][28][29]. Natural antioxidants have been found to possess the ability to effectively prevent the damage caused by ROS [30].…”

Section: Antioxidant Activity Of Poll Gland Secretionmentioning

confidence: 99%

Chemical Composition and Antioxidant Activity of the Poll Gland Secretions of the Bactrian Camel (Camelus bactrianus)

Batdorj,

Purev,

Bayandorj

et al. 2017

Cent. Asian j. Med. Sci.

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Objectives:To determine chemical composition and antioxidant activity of poll gland secretions. Methods: Physical and chemical constituents, such as moisture and ash content, were determined using standard methods, crude fat was determined using the Soxhlet method, and organic composition was analyzed using GC-MS. Macro-and micro-element contents were determined using ICP-OES. Protein concentration was determined using the Bradford assay, and protein profiles were determined using SDS-PAGE. Antioxidant activity was determined using the DPPH free-radical scavenging technique. Results: Camel poll gland secretions contained 23 minerals. Potassium (89030 mg/kg) was most predominant, followed by calcium (12955 mg/kg), iron (8546 g/kg), aluminum (6105 mg/kg), magnesium (4563 mg/kg), sodium (2452 mg/kg), and zinc (14198 mg/kg). Total protein content was 11.7%. SDS-PAGE analysis of poll gland secretions revealed the presence of three different protein bands with the molecular weights of 35kDa, 68kDa and 130.5kDa. 12 organic compounds were determined by GC-MS in the poll gland secretions. Antioxidant activity of poll gland secretions was IC 50-176.2 µg/ ml. Conclusion: Proteins with the molecular weights of 35kDa, 68kDa, and 130.5kDa were determined in poll gland secretions, and they displayed potent antioxidant activity.

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The antioxidant properties of salicylate derivatives: A possible new mechanism of anti-inflammatory activity

Cited by 40 publications

References 54 publications

Larvicidal effect of hydroethanolic extract from the leaves of Acmella oleracea L. R. K. Jansen in Aedes aegypti and Culex quinquefasciatus

Larvicidal effect of hydroethanolic extract from the leaves of Acmella oleracea L. R. K. Jansen in Aedes aegypti and Culex quinquefasciatus

Flavoenzyme‐mediated Regioselective Aromatic Hydroxylation with Coenzyme Biomimetics

Chemical Composition and Antioxidant Activity of the Poll Gland Secretions of the Bactrian Camel (Camelus bactrianus)

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