The Antioxidant Effect of Exercise: A Systematic Review and Meta-Analysis

Sousa, Caio Victor; Sales, Marcelo Magalhães; Rosa, Thiago Santos; Lewis, John E.; Andrade, Rosângela Vieira de; Simões, Herbert Gustavo

doi:10.1007/s40279-016-0566-1

Cited by 221 publications

(151 citation statements)

References 105 publications

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“…Increased exercise capacity due to improved muscle function restores glucose metabolism via means of insulin-dependent and -independent mechanisms (Holloszy, 2005). Regular physical activity has been demonstrated to exert protective effects against oxidative stress via induction of antioxidant pathways (de Sousa et al, 2017). When combined with proper dietary regime, exercise training is also effective in combating obesity, achieving better weight-control, as well as restoring endothelial function which greatly reduces individual's risk of cardiovascular comorbidities (Johansson, Neovius, & Hemmingsson, 2014;Moien-Afshari et al, 2008).…”

Section: Physical Inactivity: a Cause Or A Consequence?mentioning

confidence: 99%

Pathobiological mechanisms underlying metabolic syndrome (MetS) in chronic obstructive pulmonary disease (COPD): clinical significance and therapeutic strategies

Chan

Selemidis

Bozinovski

et al. 2019

Pharmacology & Therapeutics

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a b s t r a c t a r t i c l e i n f oChronic obstructive pulmonary disease (COPD) is a major incurable global health burden and is currently the 4th largest cause of death in the world. Importantly, much of the disease burden and health care utilisation in COPD is associated with the management of its comorbidities (e.g. skeletal muscle wasting, ischemic heart disease, cognitive dysfunction) and infective viral and bacterial acute exacerbations (AECOPD). Current pharmacological treatments for COPD are relatively ineffective and the development of effective therapies has been severely hampered by the lack of understanding of the mechanisms and mediators underlying COPD. Since comorbidities have a tremendous impact on the prognosis and severity of COPD, the 2015 American Thoracic Society/European Respiratory Society (ATS/ERS) Research Statement on COPD urgently called for studies to elucidate the pathobiological mechanisms linking COPD to its comorbidities. It is now emerging that up to 50% of COPD patients have metabolic syndrome (MetS) as a comorbidity. It is currently not clear whether metabolic syndrome is an independent co-existing condition or a direct consequence of the progressive lung pathology in COPD patients. As MetS has important clinical implications on COPD outcomes, identification of disease mechanisms linking COPD to MetS is the key to effective therapy. In this comprehensive review, we discuss the potential mechanisms linking MetS to COPD and hence plausible therapeutic strategies to treat this debilitating comorbidity of COPD.

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Section: Physical Inactivity: a Cause Or A Consequence?mentioning

confidence: 99%

Pathobiological mechanisms underlying metabolic syndrome (MetS) in chronic obstructive pulmonary disease (COPD): clinical significance and therapeutic strategies

Chan

Selemidis

Bozinovski

et al. 2019

Pharmacology & Therapeutics

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“…Furthermore, Karabulut et al [82] reported that following a 12-week aerobic exercise program, the lipid peroxidation marker malondiadehyde (MDA) significantly decreased whereas the antioxidant parameters SOD and GSH significantly increased. More recently, a systematic review and meta-analysis conducted by de Sousa et al [83] reported that physical activity induced antioxidant effects and decreased pro-oxidant effects regardless of the type of exercise, volume, intensity, and population studied. Consequently, it can be concluded that exercise is antioxidant in nature and can balance the redox state to elicit positive health outcomes.…”

Section: Antioxidants and Fshdmentioning

confidence: 99%

Are Antioxidants a Potential Therapy for FSHD? A Review of the Literature

Denny

Heather

2017

Oxidative Medicine and Cellular Longevity

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Facioscapulohumeral muscular dystrophy (FSHD) is an inherited myopathy affecting approximately 1 in 7500 individuals worldwide. It is a progressive disease characterised by skeletal muscle weakness and wasting. A genetic mutation on the 4q35 chromosome results in the expression of the double homeobox 4 gene (DUX4) which drives oxidative stress, inflammation, toxicity, and atrophy within the skeletal muscle. FSHD is characterised by oxidative stress, and there is currently no cure and a lack of therapies for the disease. Antioxidants have been researched for many years, with investigators aiming to use antioxidants therapeutically for oxidative stress-associated diseases. This has included both natural and synthetic antioxidants. The use of antioxidants in preclinical or clinical models has been largely successful with a plethora of research reporting positive results. However, when translated to clinical trials, the use of antioxidants as a therapeutic intervention for a variety of disease has been largely unsuccessful. Moreover, specifically focusing on FSHD, limited research has been conducted on the use of antioxidants as a therapy in either preclinical or clinical models. This review summarises the current state of antioxidant use in the treatment of FSHD and discusses their potential avenue for therapeutic use for FSHD patients.

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“…Regular exercise has beneficial systemic effects including the upregulation of the enzymatic antioxidant system and modulation of oxidative damage [19–21]. As such, regular exercise could play an important therapeutic role in the prevention of cognitive decline in the prodromal stages of neurodegenerative diseases [22].…”

Section: Introductionmentioning

confidence: 99%

Lipid Peroxidation Markers in Coronary Artery Disease Patients with Possible Vascular Mild Cognitive Impairment

Suridjan

Herrmann

Adibfar

et al. 2017

JAD

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This study examined associations between lipid peroxidation markers and cognition, and associations between these markers and cognitive response to an exercise intervention program, in adults with coronary artery disease at risk of dementia. Lipid peroxidation products were measured in serum in 118 patients (29 possible vascular mild cognitive impairment and 89 controls). Ratios of early- (lipid hydroperoxides, LPH) to late-stage (8-isoprostane, 8-ISO; 4-hydroxy-2-nonenal, 4-HNE) lipid peroxidation products were calculated. Cognitive performance was assessed before and at completion of a 24-week exercise intervention program. A global effect of group on lipid peroxidation markers was observed, adjusting for sex, years of education, and cardiopulmonary fitness (main effect of group F (3,102) = 2.957, p = 0.036). Lower lipid peroxidation at baseline, as determined by lower 8-ISO concentration, was associated with greater improvement in verbal memory (F (1, 64) = 4.738, p = 0.03) and executive function (F (1, 64) = 5.219, p = 0.026) performance. Similarly, higher ratios of 8-ISO/LPH (F (1, 65) = 6.592, p = 0.013) and (8-ISO+4-HNE) to LPH (F (1, 65) = 3.857, p = 0.054), were associated with less improvement in executive function performance over a 24-week exercise intervention. Lipid peroxidation may be a biomarker of early vascular cognitive impairment, and elevated lipid peroxidation might limit the cognitive benefits of exercise in this high-risk population.

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The Antioxidant Effect of Exercise: A Systematic Review and Meta-Analysis

Cited by 221 publications

References 105 publications

Pathobiological mechanisms underlying metabolic syndrome (MetS) in chronic obstructive pulmonary disease (COPD): clinical significance and therapeutic strategies

Pathobiological mechanisms underlying metabolic syndrome (MetS) in chronic obstructive pulmonary disease (COPD): clinical significance and therapeutic strategies

Are Antioxidants a Potential Therapy for FSHD? A Review of the Literature

Lipid Peroxidation Markers in Coronary Artery Disease Patients with Possible Vascular Mild Cognitive Impairment

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