The Antioxidant Capacities of Natural Products 2019

Cardoso, Susana M.; Fazio, Alessia

doi:10.3390/molecules25235676

Cited by 9 publications

(6 citation statements)

References 33 publications

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“…Oxidative stress plays a crucial role in ESC development, making targeted therapy against oxidative stress of significant importance. Currently, NPs have been extensively studied and shown to have the potential in regulating oxidative stress processes[ 82 , 83 ]. These NPs can directly act on tumor cells, exerting anti-ESC effects by modulating multiple oxidative stress pathways.…”

Section: Discussionmentioning

confidence: 99%

Targeting oxidative stress with natural products: A novel strategy for esophageal cancer therapy

Cao,

Zhang,

Guo

et al. 2024

World J Gastrointest Oncol

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Esophageal cancer (ESC) is a malignant tumor that originates from the mucosal epithelium of the esophagus and is part of the digestive tract. Although the exact pathogenesis of ESC has not been fully elucidated, excessive oxidative stress is an important characteristic that leads to the development of many cancers. Abnormal expression of several proteins and transcription factors contributes to oxidative stress in ESCs, which alters the growth and proliferation of ESCs and promotes their metastasis. Natural compounds, including alkaloids, terpenes, polyphenols, and xanthine compounds, can inhibit reactive oxygen species production in ESCs. These compounds reduce oxidative stress levels and subsequently inhibit the occurrence and progression of ESC through the regulation of targets and pathways such as the cytokine interleukins 6 and 10, superoxide dismutase, the NF-+ACY-kappa+ADs-B/MAPK pathway, and the mammalian Nrf2/ARE target pathway. Thus, targeting tumor oxidative stress has become a key focus in anti-ESC therapy. This review discusses the potential of Natural products (NPs) for treating ESCs and summarizes the application prospects of oxidative stress as a new target for ESC treatment. The findings of this review provide a reference for drug development targeting ESCs. Nonetheless, further high-quality studies will be necessary to determine the clinical efficacy of these various NPs.

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Section: Discussionmentioning

confidence: 99%

Targeting oxidative stress with natural products: A novel strategy for esophageal cancer therapy

Cao,

Zhang,

Guo

et al. 2024

World J Gastrointest Oncol

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“…Despite limitations, the study highlights the antioxidant, antibacterial, and anti-biofilm properties of the extracts, suggesting their potential in oral care. However, sustainability concerns regarding habitat destruction and biodiversity loss due to extraction processes warrant further exploration of eco-friendly alternatives, including synthetic or bioengineered compounds [101,102].…”

Section: General Aspectsmentioning

confidence: 99%

Comprehensive Bio-Screening of Phytochemistry and Biological Capacity of Oregano (Origanum vulgare) and Salvia triloba Extracts against Oral Cariogenic and Food-Origin Pathogenic Bacteria

Antoniadou,

Rozos,

Vaou

et al. 2024

Preprint

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This study utilized phytochemical screening to conduct qualitative analysis of plant extracts, aiming to identify various classes of secondary metabolites. Moreover, the antibacterial activity of different types of O. vulgare and S. triloba extracts was determined. To achieve the aim of the study, aqueous, ethanolic, and enzymatic extracts were prepared and screened for phytochemical capacity and antioxidant activities. Determination of the antibacterial activity included phenotypic screening of antibiotic susceptibility pattern of oral and food pathogenic bacterial strains, determination of Minimum inhibitory concentration and minimum bactericidal concentration - Microdilution broth test and in vitro valuation of antibacterial efficacies - anti-biofilm properties of the studied herbal extractions. Results: Our study evaluated the phytochemical composition and the antioxidant, antibacterial, and anti-biofilm properties of O. vulgare and S. triloba extracts. The analyzed samples contained bioactive compounds, such as phenolics and flavonoids, contributing to the observed strong antioxidant effect. Furthermore, they exhibited notable activity against oral biofilm formation and demonstrated significant antibacterial efficacy against dental caries microorganisms as well as food pathogens. Despite methodological variations, all extracts showed significant antioxidant capacity and promising antibacterial activity against various pathogens, including resistant strains, while also inhibiting biofilm formation. Although limited to two plant species and facing methodological constraints, the study lays a groundwork for future research, indicating the therapeutic potential of O. vulgare and S. triloba extracts. Further exploration is needed to report on underlying mechanisms and validate efficacy through clinical trials.

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“…23 On the other hand, the most studied biological activities include anticarcinogenic, antimicrobial, analgesic, healing, and antioxidant properties. 24 For carrying out studies on these properties, in vitro or in vivo systems could be employed. In the former, immortalized cell lines or primary cultures are used, while whole animal studies are done in the latter, such as rats, mice, rabbits, fish, and nematodes.…”

Section: •−mentioning

confidence: 99%

“…The secondary metabolites most extensively studied for health-promoting effects are flavonoids, terpenoids, alkaloids, saponins, and phenols . On the other hand, the most studied biological activities include anticarcinogenic, antimicrobial, analgesic, healing, and antioxidant properties . For carrying out studies on these properties, in vitro or in vivo systems could be employed.…”

Section: Introductionmentioning

confidence: 99%

Effects of Vegetal Extracts and Metabolites against Oxidative Stress and Associated Diseases: Studies in Caenorhabditis elegans

et al. 2023

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Oxidative stress is a natural physiological process where the levels of oxidants, such as reactive oxygen species (ROS) and nitrogen (RNS), exceed the strategy of antioxidant defenses, culminating in the interruption of redox signaling and control. Oxidative stress is associated with multiple pathologies, including premature aging, neurodegenerative diseases, obesity, diabetes, atherosclerosis, and arthritis. It is not yet clear whether oxidative stress is the cause or consequence of these diseases; however, it has been shown that using compounds with antioxidant properties, particularly compounds of natural origin, could prevent or slow down the progress of different pathologies. Within this context, the Caenorhabditis elegans (C. elegans) model has served to study the effect of different metabolites and natural compounds, which has helped to decipher molecular targets and the effect of these compounds on premature aging and some diseases such as neurodegenerative diseases and dyslipidemia. This article lists the studies carried out on C. elegans in which metabolites and natural extracts have been tested against oxidative stress and the pathologies associated with providing an overview of the discoveries in the redox area made with this nematode.

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The Antioxidant Capacities of Natural Products 2019

Abstract: The search for new natural antioxidants is a growing area of research due to the broad spectrum of their biological properties, which are associated with the prevention of chronic diseases that originate in oxidative stress [...]

Cited by 9 publications

References 33 publications

Targeting oxidative stress with natural products: A novel strategy for esophageal cancer therapy

Targeting oxidative stress with natural products: A novel strategy for esophageal cancer therapy

Comprehensive Bio-Screening of Phytochemistry and Biological Capacity of <em>Oregano </em>(<em>Origanum vulgare</em>) and <em>Salvia triloba</em> Extracts against Oral Cariogenic and Food-Origin Pathogenic Bacteria

Effects of Vegetal Extracts and Metabolites against Oxidative Stress and Associated Diseases: Studies in Caenorhabditis elegans

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