The Antioxidant, Anti-Platelet and Anti-Coagulant Properties of Phenolic Compounds, Associated with Modulation of Hemostasis and Cardiovascular Disease, and Their Possible Effect on COVID-19

Abstract

Patients affected by coronavirus disease 2019 (COVID-19) demonstrate a range of hemostasis dysfunctions, such as coagulation dysfunction and changes in blood platelet function, this being a major cause of death. These complications may also be associated with oxidative stress. Recently, various papers, including some reviews, have suggested that the use of dietary bioactive compounds, including phenolic compounds, may play a significant role in the treatment of COVID-19. However, while some phenolic compounds, such as curcumin, resveratrol, myricetin and scutellarian, have been found to have antiviral effects against COVID-19, recommendations regarding the use of such compounds to prevent or reduce the risk of CVDs during COVID-19 infection remain tentative. The present mini-review examines the antioxidant, anti-platelet and anticoagulant and antiviral activities of selected phenolic compounds and the possible implications for their use in treating CVDs associated with COVID-19. This review also examines whether these phenolic compounds can be promising agents in the modulation of hemostasis and CVDs during COVID-19. While their properties have been well documented in various in vitro and in vivo studies, particularly their positive role in the prophylaxis and treatment of CVDs, less is known regarding their prophylactic potential against CVDs during COVID-19, and no credible evidence exists for their efficiency in humans or animals. In such cases, no in vitro or in vivo studies are available. Therefore, it cannot be unequivocally stated whether treatment with these phenolic compounds offers benefits against CVDs in patients with COVID-19.

Screening and evaluation of cytotoxicity and antiviral effects of secondary metabolites from water extracts of Bersama abyssinica against SARS-CoV-2 Delta

“…Recent study in Egypt revealed that medicinal plants have possessed high active metabolites for inhibition of Coronavirus [ 53 ]. The results from this study are supported by previous works that revealed the antiviral activity of herbal medicines though ant oxidation, anticoagulation and anti-inhibitory activity of natural phenolic compounds [ 54 – 56 ]. Several efforts toward discovery of SARS Cov-2 have been investigated though preclinical and clinical trials [ 57 ].…”

Consideration for Flavonoid-Containing Dietary Supplements to Tackle Deficiency and Optimize Health

“…The flavonol quercetin is a well-known antiplatelet compound which can inhibit platelet aggregation through various signaling pathways and, thus, may play a crucial role in the prevention of thrombosis and cardiovascular disease [64,65]. Furthermore, the anticoagulant and anti-platelet effects of quercetin can be beneficial for treating viral diseases such as COVID-19, since the infection may initiate thrombotic events through changes in platelet aggregation [66]. Thus, quercetin received attention during the COVID-19 pandemic because of its versatile anti-SARS-CoV-2 effects [67][68][69].…”

Curcuminoids: Composition, extraction, health benefits, delivery systems, and relation to COVID‐19 treatment

“…K E Y W O R D S bioactive compounds, Covid-19, curcuminoids, extraction techniques, health benefits 1 | INTRODUCTION Curcuminoids are bioactive components extracted from rhizomes of Curcuma longa, an annually growing herb belongs to the family ofZingiberaceae. In Asian middle-east countries, turmeric is used as spice, preservative, food additive, coloring agent, as medicine, and consumed daily for many culinary applications (Khan et al, 2022;Olas, 2022;Zhang & Kitts, 2021). Curcuminoids are a family of bioactive components present in turmeric that constitutes upto 1%-6% by weight and distributed as curcumin (Cur), demethoxycurcumin (DMC), and bisdemethoxycurcumin (BDMC).…”

“…These compounds are linear, diarylheptanoid molecules, arguably one of the highly investigated phytochemical that vary in chemical structures and functional properties (Amalraj et al, 2017).Curcuminoids are lipophilic natural chemical compounds that contain wide variety of therapeutic properties. Generally, they act as natural ligands with peroxisome proliferator-activated receptor-γ, which has the ability to reduce production of cytokine, and thus they function as anti-inflammatory, antioxidant, antiviral, and anticancer agent (Olas., 2022;Yang et al, 2023;Yang et al, 2023;Zahedipour et al, 2020). Many studies have demonstrated that curcumin, the primary pigment in turmeric, exhibits a wide range of in vivo pharmacological activities, such as cardio-protective, hepato-protective…”

“…Zingiberaceae. In Asian middle-east countries, turmeric is used as spice, preservative, food additive, coloring agent, as medicine, and consumed daily for many culinary applications (Khan et al, 2022;Olas, 2022;Zhang & Kitts, 2021). Curcuminoids are a family of bioactive components present in turmeric that constitutes upto 1%-6% by weight and distributed as curcumin (Cur), demethoxycurcumin (DMC), and bisdemethoxycurcumin (BDMC).…”