The antioxidant alpha‐lipoic acid improves endothelial dysfunction induced by acute hyperglycaemia during OGTT in impaired glucose tolerance

Abstract

In subjects with IGT, FMD was impaired both in the fasting state and after a glucose challenge, probably through increased production of oxygen-derived free radicals. The ED observed after a glucose challenge is related to the extent of hyperglycaemia and TBARS, and an antioxidant agent can improve the impairment of endothelial function induced by acute hyperglycaemia.

Alpha‐lipoic acid improves vascular endothelial function in patients with type 2 diabetes: a placebo‐controlled randomized trial

“…Consistent with these experimental data, there is evidence that oral supplementation of ALA decreases oxidative stress in diabetic patients as assessed by measurement of plasma lipid hydroperoxides [9]. A recent study in patients with impaired glucose tolerance showed beneficial effects of short-term ALA (300 mg) on endothelial function [22].…”

The role of oxidative stress in postprandial endothelial dysfunction

“…For instance, Kawano et al (54) observed significant postprandial elevations in TBARS and attenuated flow-mediated dilatation of the brachial artery following an OGTT in subjects with IGT and T2DM while healthy controls were not significantly affected by such challenge. Xiang et al (53) observed similar findings in subjects with IGT and, like Kawano et al (54) , observed a positive correlation between postprandial oxidative stress and endothelial dysfunction.…”

Impact of cardiac magnetic resonance on endothelial function in type 2 diabetic patients

“…Previous studies have established that oxygen-derived free radicals interfere with or destroy FMD by inactivating NO in normal vessels [21,22]. Recently, some studies have documented that plasma TBARS, a marker of oxygen-derived free radicals, is negatively related to the FMD of the brachial conduit artery [18,23]. In the present study, we found that the TBARS levels increase markedly at Day 1 after CMR, which is inversely associated with FMD during the follow-up days.…”