The antioxidant activity, preliminary phytochemical screening of <i>Zingiber zerumbet</i> and antimicrobial efficacy against selective endodontic bacteria

Assiry, Ali A; Ahmed, Naveed; Almuaddi, Abdulmajeed; Saif, Ahmed; Alshahrani, Mohammed Abdulrahman; Mohamed, Roshan Noor; Karobari, Mohmed Isaqali

doi:10.1002/fsn3.3462

Cited by 2 publications

(1 citation statement)

References 38 publications

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“…In the past decade, there has been a rise in interest in dentistry and medicine related to Enterococcus faecalis (Assiry et al, 2023;Karobari et al, 2022) and several herbal fruit extracts (Al-Musawi et al, 2022;Khudier et al, 2023). It is challenging to eradicate a pathogen from a root canal utilizing chemomechanical preparation, disinfecting irrigants, and antibacterial dressings in post-treatment endodontic infection (Ahmed et al, 2022;Kandaswamy & Venkateshbabu, 2010).…”

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confidence: 99%

Evaluation and comparison of antibacterial efficacy of different concentrations of Chhattisgarh herbal product—Terminalia chebula fruit extract in opposition to Enterococcus faecalis: An in vitro study

Doye,

Malur,

Sahu

et al. 2023

Food Science & Nutrition

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Due to the low cost, natural origin, higher safety margins, and little to negligible adverse effects of herbal medications, the use of plants and plant derivatives in medicine is becoming increasingly widespread. Terminalia chebula is among the most significant medicinal plants in ayurvedic, siddha, unani, and homeopathic remedies. It is ranked first in Ayurvedic material medicine. T. chebula has been shown to have established effects against various bacterial and fungal infections, including dental caries pathogens. In recent years, there has been a rise in interest in dentistry and medicine related to Enterococcus faecalis. The research aimed to assess the antibacterial effectiveness of different concentrations of T. chebula ethanolic fruit extract (10%, 40%, and 100%) in opposition to E. faecalis and compare it with 2% chlorhexidine. For the study, T. chebula ethanolic fruit extracts were obtained and prepared with Group I: −10% concentration, Group II: −40% concentration, Group III: −100% concentration, and Group IV: −2% chlorhexidine. Colonies of E. faecalis were cultivated in brain heart infusion (BHI) broth at 37°C and were inoculated in 16 BHI agar plates. Then, on the petri dishes, four wells were created (8 mm diameter) using a metal borer. The Agar well diffusion method was used to examine the antibacterial activity, and the zones of inhibition around the wells were noted. The obtained data were statistically analyzed using one‐way ANOVA and post‐hoc tests. The result shows that as the concentration increases, there is an increase in the efficacy of the antibacterial property of the extract before it reaches the saturation point. The decreasing order of antibacterial was chlorhexidine >100% T. chebula >40% T. chebula >10% T. chebula. The production of contemporary pharmaceuticals from T. chebula was addressed, as the global scenario is currently evolving toward using nontoxic plant products with traditional medicinal benefits.

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Section: Introductionmentioning

confidence: 99%

Evaluation and comparison of antibacterial efficacy of different concentrations of Chhattisgarh herbal product—Terminalia chebula fruit extract in opposition to Enterococcus faecalis: An in vitro study

Doye,

Malur,

Sahu

et al. 2023

Food Science & Nutrition

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Phytochemical Composition and Antimicrobial Efficacy of Salvadora persica Root Extracts Against Carbapenem-Resistant Acinetobacter baumannii

Wan Alias,

Ismail,

Hasan

et al. 2024

Cureus

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Background Carbapenem-resistant Acinetobacter baumannii (CRAB) are difficult to eradicate from the environment and are virtually immune to all antibiotics. Consequently, CRAB may culminate in severe outbreaks and fatal infections among people attending hospitals and nursing homes. Salvadora persica has been used as an herbal remedy and chewing sticks for dental cleansing. Evaluating S . persica 's efficacy against CRAB may provide an alternative approach to treating CRAB infections in healthcare environments, considering its traditional application in dental hygiene. Employing S. persica as an herbal remedy could be a part of a more sustainable approach to control CRAB infections. Aim To investigate the phytochemical composition of S. persica and evaluate its antimicrobial properties. Materials and methods The roots were extracted by Soxhlet apparatus using n-hexane, chloroform, and methanol. Each extract was analyzed using gas chromatography-mass spectrometry (GCMS) and characterized using WN908.L and National Institute of Standards and Technology (NIST) libraries. The antimicrobial activity of each extract against CRAB was evaluated using a broth microdilution assay to determine the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). Results The GCMS analysis of different solvent extracts of S. persica roots showed the presence of various phytochemical compounds such as steroids, phenolic compounds, fatty acids, alcohols, terpenoids, and vitamin E. Both chloroform and hexane extracts showed the most effective antimicrobial activity with a MIC value of 3.13 mg/mL and an MBC value of 12.50 mg/mL, respectively. Benzoic acid was the major phytochemical compound identified from S. persica extract. N-hexane, chloroform, and methanol extracts exhibited maximum antimicrobial activity due to the presence of active compounds in them. Conclusion Chloroform and hexane extracts showed the most potent antibacterial activities against CRAB.

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The antioxidant activity, preliminary phytochemical screening of Zingiber zerumbet and antimicrobial efficacy against selective endodontic bacteria

Cited by 2 publications

References 38 publications

Evaluation and comparison of antibacterial efficacy of different concentrations of Chhattisgarh herbal product—Terminalia chebula fruit extract in opposition to Enterococcus faecalis: An in vitro study

Evaluation and comparison of antibacterial efficacy of different concentrations of Chhattisgarh herbal product—Terminalia chebula fruit extract in opposition to Enterococcus faecalis: An in vitro study

Phytochemical Composition and Antimicrobial Efficacy of Salvadora persica Root Extracts Against Carbapenem-Resistant Acinetobacter baumannii

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