The antioxidant activity of <i>Clitoria ternatea</i> flower petal extracts and eye gel

Kamkaen, Narisa; Wilkinson, Jenny M.

doi:10.1002/ptr.2832

Cited by 67 publications

(46 citation statements)

References 11 publications

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“…Hinava Sada Tongii is a fish salad also from Kadazandusun community evidence indicates petals to be an excellent source of anthocyanins, as well as contain ample amounts of triterpenoids, flavonols, and ternatins glycosides. In addition, flower extract is reported to possess antioxidant, antidiabetic, anti-inflammatory, and antimicrobial activities [28,47,66].…”

Section: Popular Cooked Foods a Nasi Kerabumentioning

confidence: 99%

Healthy food traditions of Asia: exploratory case studies from Indonesia, Thailand, Malaysia, and Nepal

et al. 2019

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Asia represents rich traditional dietary diversity. The rapid diet transition in the region is leading to a high prevalence of non-communicable diseases. The aim of this exploratory study was to document traditional foods and beverages and associated traditional knowledge that have potential positive health impacts, from selected countries in the region. The study also focused on identifying their importance in the prevention and management of lifestyle-related diseases and nutritional deficiencies as well as for the improvement of the overall health and wellbeing. This was conducted in selected locations in Indonesia, Thailand, Malaysia and Nepal through a qualitative method with a pre-tested documentation format. Through a detailed documentation of their health benefits, the study tries to highlight the significance of traditional foods in public health as well as their relevance to local market economies towards sustainable production and consumption and sustainable community livelihoods.

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Section: Popular Cooked Foods a Nasi Kerabumentioning

confidence: 99%

Healthy food traditions of Asia: exploratory case studies from Indonesia, Thailand, Malaysia, and Nepal

et al. 2019

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“…VEGF quantification provides additional support by proving dose dependent action of MECT in reducing VEGF secretion in-vivo and the effect was compared with untreated EAC bearing mice where increased VEGF level was observed over the growth period. Further, VEGF is been considered as a key inducer of angiogenesis in tumour condition [21]. As part of the study that involves phytochemical identification from C. ternatea flower was performed by LC-MS analysis.…”

Section: Discussionmentioning

confidence: 99%

“…The plant is reputed for its folkloric uses in various diseases [20]. The various parts of the plant has been scientifically evaluatedd for various pharmacological activities including antioxidant [21], anthelmintic [22], analgesic, anxiolytic [23], antidepressant, anticonvulsant [24], hypoglycemic [25], larvicidal [26] and cytotoxic [27] activities. This particular study is an evaluation of angio-suppressive activity of methanol extract of C. ternatea flowers (MECT) in Ehrlich ascites carcinoma (EAC) model in-vivo.…”

Section: Introductionmentioning

confidence: 99%

Angio Suppressive Effect of Clitoria ternatea Flower Extract is Mediated by HIF-1α and Down Regulation of VEGF in Murine Carcinoma Model

Balaji¹,

Shivaprakash²,

Preethi³

et al. 2016

Med chem (Los Angeles)

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Angiogenesis is a vital process in the progression of cancer as it also play a key role in tumor transition from its dormant state to a malignant stage. VEGF is key growth factor plays an important role in angiogenesis and is regulated by transcription factor HIF-1α. Natural compounds derived from plants have been a prime source for numerous clinically useful anti-cancer agents specially for targeting neo-angiogenesis. Medicinal plants continue to play a central role in the healthcare system of large proportions of the world's population, particularly true in developing countries like India. In the current report, we studied the angio suppressive effect of aqueous extract of Clitoria ternatea in EAC cells induced angiogenesis. In vivo anti-angiogenic effect of C. ternatea was demonstrated by the down regulation of VEGF secretion from Ehrlich ascites carcinoma (EAC) cells and inhibition of blood vessels formation indicating the potential angio suppressive effect of plant. HIF-1α protein, a transcription factor known to be key a regulator in hypoxia-induced angiogenesis was also down regulated by C. ternatea. Our invetigation indicated that, HIF-1α nuclear sequestration is repressed by C. ternatea through inhibition of nuclear translocation. We hypothesize that decreased levels of HIF-1α in the nucleus of EAC cells upon MECT treatment could be responsible for decreased expression of VEGF which is also attributed to the angio-suppressive effects of MECB. C. ternatea promises to be a potential anti-angiogenic plant which can be exploited to treat cancer.

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“…Solvents (acetone, ethanol, ethyl acetate, petroleum ether and water) were retained based on previous studies on antioxidant compounds that underlined their extraction effectiveness (Kamkaen and Wilkinson 2009;Stanković et al 2010;Stanković and Topuzović 2012).…”

Section: Antioxidant Compoundsmentioning

confidence: 99%

DNA damage protection, antioxidant and free-radical scavenging activities ofMyriophyllum alterniflorumDC (Haloragaceae) vegetative parts

Delmail¹,

Abasq²,

Courtel³

et al. 2013

Acta Botanica Gallica

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DNA damage induced by free radicals is associated with mutation-based health impairment and cancers. The protective effect of five different extracts from an aquatic macrophyte, the alternate water-milfoil Myriophyllum alterniflorum DC (Haloragaceae), is investigated on the DNA disruption mediated by hydroxyl (HO • ) and hydroperoxyl (HOO • ) radicals, and their antioxidant activity on 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals and O 2 •À . Indeed, M. alterniflorum is supposed to be a good candidate for DNA protection as this species was recently used in ecological surveys as a bioindicator of water quality because of its ability to cope with and to reflect the heavy-metal pollution through variations of antioxidant contents. Moreover, preliminary results indicated higher levels of scavengers specialized in reactive oxygen species reduction, than common medicinal plants. Acetone and ethanol extracts from vegetative parts limit significantly the oxidative damage of plasmid DNA induced by Fenton-reaction reactive oxygen species. The radical antioxidant activities of acetone and aqueous extracts are higher than those of other solvents:[DPPH] IC 50 = 2.4 ± 0.2 mg.ml -1 and [O 2•À ] AI 50 = 220.0 ± 14.1 μg.ml -1 , respectively. Protection towards free radicals is correlated with high contents of antioxidant compounds in acetone extracts [phenol compounds: 21.00 ± 0.69 mg gallic acid.g -1 DW (dry weight)] and aqueous extracts (flavonoids: 125.48 ± 1.26 mg rutin.g -1 DW). Myriophyllum alterniflorum can be regarded as a promising natural-product source of antigenotoxics and antioxidants and could be envisaged for therapeutic purposes.

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The antioxidant activity of Clitoria ternatea flower petal extracts and eye gel

Cited by 67 publications

References 11 publications

Healthy food traditions of Asia: exploratory case studies from Indonesia, Thailand, Malaysia, and Nepal

Healthy food traditions of Asia: exploratory case studies from Indonesia, Thailand, Malaysia, and Nepal

Angio Suppressive Effect of Clitoria ternatea Flower Extract is Mediated by HIF-1α and Down Regulation of VEGF in Murine Carcinoma Model

DNA damage protection, antioxidant and free-radical scavenging activities ofMyriophyllum alterniflorumDC (Haloragaceae) vegetative parts

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