The antioxidant activity and genotoxicity of isogarcinol

Liu, Zijin; Li, Gang; Cheng, Long; Xu, Jing; Cen, Juren; Yang, Xiaobo

doi:10.1016/j.foodchem.2018.01.074

Cited by 37 publications

(30 citation statements)

References 36 publications

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“…Growing amount of studies on natural antioxidants have been conducted in recent years due to high content of bioactive components [ 1 ], and people’s concern about the use of synthetic antioxidants. Nowadays, synthetic antioxidants are widely used in pharmaceuticals, cosmetics and food products, but their long-term use is accompanied by toxic and other side effects [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Comparative Phytochemical Profiles and Antioxidant Enzyme Activity Analyses of the Southern Highbush Blueberry (Vaccinium corymbosum) at Different Developmental Stages

Sun

Mitra

et al. 2018

Molecules

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In this study, the fruit quality, anthocyanin content and antioxidant enzyme activities of skin and pulp of southern blueberries (Vaccinium corymbosum) from China y at five developmental stages (green, pink, red, purple and blue) were investigated and anthocyanins were characterized and quantified by HPLC during the considered developmental stages. The results indicatated that the contents of phenolic, flavonoids and anthocyanin as well as antioxidant enzyme activities varied depending on the developmental stages. The correlation values between total phenolic content (TPC), total flavonoids content (TFC) and total anthocyanin content (TAC) were significant. The highest activity of peroxidase (POD) and catalase (CAT) was found in red fruit, and the variety of monomeric anthocyanin increased gradually, skin from blue fruit possessed higher TAC. However, the highest activity of polyphenol oxidase (PPO) and superoxide dismutase (SOD) were detected in green and blue fruit, respectively. In the present work, the differences regarding phytochemical profiles and antioxidant enzyme activities were mainly correlated with developmental stages of fruit.

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Section: Introductionmentioning

confidence: 99%

Comparative Phytochemical Profiles and Antioxidant Enzyme Activity Analyses of the Southern Highbush Blueberry (Vaccinium corymbosum) at Different Developmental Stages

Sun

Mitra

et al. 2018

Molecules

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“…[10] Only recently, isogarcinol was reported to have significant antioxidant effects rescuing human cells from oxidative stress while the genotoxicity of isogarcinol was negligible. [64] Topically applied garcinol efficiently blocked skin inflammation and tumorigenesis induced by 12-O-tetradecanoylphorbol 13-acetate in mice by suppression of NF-κB, ERK, JNK, p38 MAPK, PI3 K and Akt. [65] Intimal hyperplasia is based on vascular inflammation and NFk B activation and the HAT PCAF promoted NF-κB-regulated inflammation.…”

Section: New Effects On Inflammation Processes and Neurodegenerative mentioning

confidence: 98%

“…The antioxidant and anti‐inflammatory properties of garcinol and isogarcinol are well described ( Table ) . Only recently, isogarcinol was reported to have significant antioxidant effects rescuing human cells from oxidative stress while the genotoxicity of isogarcinol was negligible . Topically applied garcinol efficiently blocked skin inflammation and tumorigenesis induced by 12‐ O ‐tetradecanoylphorbol 13‐acetate in mice by suppression of NF‐ κ B, ERK, JNK, p38 MAPK, PI3 K and Akt .…”

Section: New Effects On Inflammation Processes and Neurodegenerative mentioning

confidence: 99%

Chemical and Biological Aspects of Garcinol and Isogarcinol: Recent Developments

Schobert

Biersack

2019

Chemistry & Biodiversity

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The natural polyisoprenylated benzophenone derivatives garcinol and isogarcinol are secondary plant metabolites isolated from various Garcinia species including Garcinia indica. This review takes stock of the recent chemical and biological research into these interesting natural compounds over the last five years. New biological sources and chemical syntheses are discussed followed by new insights into the activity of garcinol and isogarcinol against cancer, pathogenic bacteria, parasite infections and various inflammatory diseases.

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“…For instance, α-mangostin prevented the increase of pro-inflammatory cytokines such as IL-6, Interleukin-1β (IL-1 β) and TNF-α after treatment with APAP and inhibited the increase of nitric oxide synthase (iNOS) expression, which further protects the liver tissue (Fu et al 2018). Furthermore, isogarcinol has been shown to possess anti-oxidant activity, without cytotoxic and genotoxic effects on HepG2 liver cells (Liu et al 2018). The compound also protects those cells from oxidative damage by H 2 O 2 , perhaps by increasing anti-oxidant enzymes such as superoxide dismutase (SOD) and glutathione as well as reducing the level of active Caspase-3 important for apoptosis (Liu et al 2018).…”

Section: Various Organ Protectionmentioning

confidence: 99%

“…Furthermore, isogarcinol has been shown to possess anti-oxidant activity, without cytotoxic and genotoxic effects on HepG2 liver cells (Liu et al 2018). The compound also protects those cells from oxidative damage by H 2 O 2 , perhaps by increasing anti-oxidant enzymes such as superoxide dismutase (SOD) and glutathione as well as reducing the level of active Caspase-3 important for apoptosis (Liu et al 2018). Wang et al (2018a) further showed that another major compound from mangosteen, γmangostin also exhibited hepatoprotective ability.…”

Section: Various Organ Protectionmentioning

confidence: 99%

Peer Review #2 of "Recent updates on metabolite composition and medicinal benefits of mangosteen plant (v0.2)"

2019

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Background. Mangosteen (Garcinia mangostana L.) fruit has unique sweet-sour taste and rich in beneficial compounds such as xanthones. Mangosteen has been originally used in various folk medicines to treat diarrhea, wound and fever. More recently, it has been used as a major component in health supplement products for weight loss and promoting general health. This is perhaps due to its known medicinal benefits including as anti-oxidant and anti-inflammation. Interestingly, the publications related to mangosteen has surged in recent years suggesting its popularity and usefulness in research laboratories. However, there is still no updated reviews (up to 2018) in this booming research area, particularly on its metabolite composition and medicinal benefits. Method. In this review, we have covered recent articles within the year of 2016 to 2018, which focuses on several aspects including the latest findings on compound composition from mangosteen fruit as well as its medicinal usages. Result. Mangosteen has been vastly used in medicinal area including as anti-cancer, anti-microbial and anti-diabetes treatments. Furthermore, we have also described the benefits of mangosteen extract in protecting various human organs such as liver, skin, joint, eye, neuron, bowel and cardiovascular tissues against disorders and diseases. Conclusion. All in all, this review describes the numerous manipulations of mangosteen extracted compounds in medicinal areas and highlights the current trend of its research. This will be important for future directed research and may allow researchers to tackle the next big challenge in mangosteen study; drug development and human applications.

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The antioxidant activity and genotoxicity of isogarcinol

Cited by 37 publications

References 36 publications

Comparative Phytochemical Profiles and Antioxidant Enzyme Activity Analyses of the Southern Highbush Blueberry (Vaccinium corymbosum) at Different Developmental Stages

Comparative Phytochemical Profiles and Antioxidant Enzyme Activity Analyses of the Southern Highbush Blueberry (Vaccinium corymbosum) at Different Developmental Stages

Chemical and Biological Aspects of Garcinol and Isogarcinol: Recent Developments

Peer Review #2 of "Recent updates on metabolite composition and medicinal benefits of mangosteen plant (v0.2)"

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