The Antioxidant Activities of Natural Polysaccharides

Huang, Gangliang; Mei, Xiaoguang; Hu, Jinchuan

doi:10.2174/1389450118666170123145357

Cited by 147 publications

(62 citation statements)

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“…Along with green tea catechins and avonols, polysaccharides are also gaining attention due to their health bene ts, especially immune response [40,79]. Air pollution has increased concern about its inhalation toxicity.…”

Section: Discussionmentioning

confidence: 99%

“…Plant avonols exhibit anticancer, proapoptotic, antioxidant, antibacterial, and anti brotic effects [31,32,33,34,35]. Additionally, polysaccharides exert several health-promoting effects, such as antibacterial, antitumor, antioxidant, and anti-in ammatory effects [36,37,38,39,40,41,42]. Despite exerting these positive effects, green tea avonols and polysaccharides, unlike catechins, have received little attention with respect to their use and functionality.…”

Section: Introductionmentioning

confidence: 99%

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Combination of green tea catechins, polysaccharides, and flavonols against urban fine dust particle-induced bronchial damage mediated by modulation of inflammation factors and airway cilia

Kim

Choi

et al. 2020

Preprint

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Background Many studies have reported that environmental pollution has become a serious public health issue. Airborne fine dust particles (FDPs) have been identified as major toxins in air pollution that threaten human respiratory health. Developing strategies for defense against FDPs is one of the primary goals of air pollution research. Results While searching for an anti-FDP reagent, we found that green tea extract (GTE) and green tea fractions rich in flavonol glycosides (FLGs) and crude green tea polysaccharides (CTPs) had protective effects against FDP-stimulated cellular damage in the BEAS-2B airway epithelial cell line. The results demonstrated that GTE, FLGs, and CTPs significantly increased viability and lowered oxidative stress levels in FDP-treated cells. Major catechin and flavonol compounds increased cell survival, and (-)-epigallocatechin gallate (EGCG) and myricetin exerted synergistic effects on cell survival under FDP stimulation. Combined treatment with GTE, FLGs, and CTPs also exerted synergistic protective effects on cells, and the green tea components attenuated FDP-induced elevations in inflammatory gene expression. Moreover, the green tea components increased the proportion of ciliated cells and upregulated ciliogenesis in the airway in FDP-stimulated BEAS-2B cells. Conclusions Our findings provide insights into how natural phytochemicals protect the airway and suggest that green tea could be used to reduce FDP-induced airway damage as an individual therapeutic agent or as an ingredient in pharmaceutical and cosmeceutical products.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Combination of green tea catechins, polysaccharides, and flavonols against urban fine dust particle-induced bronchial damage mediated by modulation of inflammation factors and airway cilia

Kim

Choi

et al. 2020

Preprint

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show abstract

“…These effects of antitumor and immune regulation are related to their antioxidant properties (Huang, Mei, & Hu, 2017). The DPPH radical scavenging capacity of polysaccharides was recognized because of the hydrogen donating capacity of polysaccharides (Khemakhem, Abdelhedi, Trigui, Ayadi, & Bouaziz, 2018).…”

Section: Scavenging Capacity On Dpphmentioning

confidence: 99%

Polysaccharides production from soybean curd residue via Morchella esculenta

Tang

Wei

et al. 2019

J Food Biochem

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To minimize the serious environmental pollution caused by food byproducts, soybean curd residue was used as the substrate to ferment polysaccharides by Morchella esculenta. Water‐soluble crude polysaccharides (CMP) were purified by different gradient concentrations (30%, 60%, and 90%) of ethanol into three precipitation fractions. The experimental results indicated that the precipitated polysaccharides by the ethanol concentration of 60% (PMP) had the highest purity, containing rhamnose, arabinose, xylose, mannose, glucose, and galactose, with the molar ratio of 0.08:0.25:0.16:0.07:0.28:1.00. The physicochemical properties were revealed by SEM, AFM, FTIR, NMR, and Congo red test. Furthermore, the measurement of antioxidant activities in vitro demonstrated that PMP exhibited higher antioxidant capacities with the dose‐dependent manner than CMP and polysaccharides from unfermented soybean curd (USP). Overall, the results suggested that PMP had attractive functional activity which could be potentially utilized in functional food industries. Practical applications The polysaccharides from fungi sources are increasingly being used in functional food and pharmaceutical industry. In allusion to the problem of polysaccharides fermented by edible fungi, such as low yield, high cost, and hard to controllable. Soybean curd residue (SCR), a food waste, has been successfully used for the production of polysaccharides and graded ethanol was used to enhance polysaccharides production, lower the difficulty and homologous costs of purity. The results indicated that the purified polysaccharides displayed excellent antioxidant activities on scavenging DPPH and hydroxyl radicals. The outcomes of this work can provide technical support for comprehensive utilization of SCR and references for promotion and application of polysaccharides fermented from SCR via Morchella esculenta in food and medicine fields.

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“…Because of the fact that most of the modern therapies to treat lifestyle diseases involve serious side effects, there is a growing interest in the use of natural therapeutics for prevention and treatment of many human diseases caused by oxidative stress that include immune disorders and cancer. In this context, Australian sweet lupin seeds possess huge potential as they are nutritionally rich and contain non-starch polysaccharides that display a range of important biological activities [9,[25][26][27][28][29] with least side effects.…”

Section: Cell Viabilitymentioning

confidence: 99%

Biological activities and characterization of polysaccharides from the three Australian Sweet Lupins

Thambiraj

Reddy

Phillips

et al. 2019

International Journal of Food Properties

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Lupin is a major rotational crop produced abundantly in Australia. Three varieties of sweet lupins are grown in Australia depending on soil types and climatic conditions; these are white lupin (Lupinus albus), blue lupin (Lupinus angustifolius), and yellow lupin (Lupinus luteus). In this study, polysaccharides from the three lupin species have been extracted with hot water and a range of their biological activities investigated. The antioxidant activities of lupin polysaccharides have been measured in terms of ABTS •+ radical and hydroxyl radical scavenging activities, and their affinity to chelate with iron. Immuneenhancing power of the lupin polysaccharides was examined by measuring their capacity to stimulate the macrophages (RAW 264.7) to release TNF-α and nitric oxide. The prebiotic activities were determined against the beneficial probiotics such as Lactobacillus rhamnosus DR20, Lactobacillus acidophilus LAFTI L10, Bifidobacterium lactis DR10, and Bifidobacterium animalis BB-12. Polysaccharides from the three lupin species have exhibited significant antioxidant, immunostimulatory, and prebiotic activities. The results demonstrated that blue lupins displayed the best activities, and therefore are expected to possess high potential to be used as nutraceutical and functional ingredients with significant therapeutic value. FT-IR spectroscopic technique was employed for a preliminary structural characterization. Studies involving surface morphology and thermal behavior have indicated that the lupin polysaccharides are suitable for end product development.

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The Antioxidant Activities of Natural Polysaccharides

Abstract: It is important to study the antioxidant activities of polysaccharides and their derivatives for the development of natural antioxidants.

Cited by 147 publications

References 0 publications

Combination of green tea catechins, polysaccharides, and flavonols against urban fine dust particle-induced bronchial damage mediated by modulation of inflammation factors and airway cilia

Combination of green tea catechins, polysaccharides, and flavonols against urban fine dust particle-induced bronchial damage mediated by modulation of inflammation factors and airway cilia

Polysaccharides production from soybean curd residue via Morchella esculenta

Biological activities and characterization of polysaccharides from the three Australian Sweet Lupins

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