The Antinociceptive Effects of Tualang Honey in Male Sprague-Dawley Rats: A Preliminary Study

Aziz, Che Badariah Abd; Ismail, Che Aishah Nazariah; Hussin, Che Maraina Che; Mohamed, Mahaneem

doi:10.4103/2225-4110.139115

Cited by 20 publications

(20 citation statements)

References 28 publications

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“…Glucocortocoid such as prednisolone suppressed IL-6 and IL-8 productions by inhibiting gene transcription of both cytokines [56]. The direct binding of glucocorticoid or GCR to glucocorticoid responsive elements in the promoter region of the gene may eventually modulate several genes expression involving in inflammatory responses [57][58][59].…”

Section: Discussionmentioning

confidence: 99%

Preemptive Effects of Administration of Tualang Honey on Inflammatory Responses in Adult Male Rats

Ismail

Hussin

Mohamed

et al. 2017

J. Pharm. Nutr. Sci.

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Background: Honey was reported to reduce pain and inflammation from burn wound. To date, no study has compared between the effects of Tualang honey and prednisolone on inflammatory responses in rats. This study has examined the effects of Tualang honey and prednisolone on inflammatory pain and its associated inflammatory responses secondary to formalin injection. Methods: Twenty-one Sprague-Dawley male rats were randomised into control, Tualang honey (1.2 g/kg) or prednisolone (10 mg/kg) groups. Formalin test was conducted and the rats were sacrificed at four-hours post-formalin injection. Serum was collected for measurement of leukocyte counts and interleukins level. All data were analysed using one-way ANOVA with post-hoc Scheffe's or Dunnet's C test. Significance level was taken as less than 0.05. Results: Tualang honey and prednisolone groups had significantly reduced pain behaviour and paw edema compared to control group. Tualang honey group demonstrated a significant increase in blood neutrophil count while prednisolone group had significant reduction in blood lymphocyte and monocyte counts compared to control group. Only interleukin-6 level was significantly reduced in honey group. Both interleukin-6 and-8 levels were significantly reduced in prednisolone group. Conclusions: Tualang honey is comparable to prednisolone in modulating the inflammatory pain responses in rats; however, with regards to local and systemic inflammatory responses, it has differential effects compared to prednisolone.

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Section: Discussionmentioning

confidence: 99%

Preemptive Effects of Administration of Tualang Honey on Inflammatory Responses in Adult Male Rats

Ismail

Hussin

Mohamed

et al. 2017

J. Pharm. Nutr. Sci.

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“…It increases caspase 3 activation and poly (ADP-ribose) polymerase (PARP) cleavage, modulates the expression of pro-and anti-apoptotic proteins, induces the expression of p53, caspase 3, and proapoptotic protein Bax and downregulates the expression of anti-apoptotic protein Bcl2 [46] . As for the anti-inflammatory activity of honey, it has been proven that honey reduces the release of nitrous oxide, cytokines (TNF-α, IL-1β, IL-2, IL-6, and PGE2) and histamines which reduces inflammation and as well as pain [58,81]. Antinociceptive property of honey is due to its ability to reduce plasma prostaglandins such as thromboxane B2, PGE2 and PGF2a [58,82] .…”

Section: G a L L E Y P R O O F Discussionmentioning

confidence: 99%

“…As for the anti-inflammatory activity of honey, it has been proven that honey reduces the release of nitrous oxide, cytokines (TNF-α, IL-1β, IL-2, IL-6, and PGE2) and histamines which reduces inflammation and as well as pain [58,81]. Antinociceptive property of honey is due to its ability to reduce plasma prostaglandins such as thromboxane B2, PGE2 and PGF2a [58,82] . The low water content and low pH (acidic) of honey due to the formation of gluconic acid results to an environment that is not favourable for bacteria to grow thus contributing to its antibacterial property [59] apart from having high viscosity that limits the solubility of oxygen and substances.…”

Section: G a L L E Y P R O O F Discussionmentioning

confidence: 99%

Honey as Versatile Remedy: A Focus on Selected Honeys

Hassan

Internationals

2019

IJFNS

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Introduction: Honey is one of the oldest traditional medicines. It has been well known that honey contains various components that could be use as treatment option. Most commonly studied honeys include gelam, kelulut, acacia, tualang and pineapple honeys. This review listed the five most commonly studied honeys, its properties and the study model involved.Results: Honey has been reported to have multiple properties. Honeys were used to study their antimicrobial properties which includes antibacterial and antifungal, anti-inflammatory, antioxidant, anti-ulcer and wound healing, anticancer properties. Interestingly, tualang honey was used to study cognitive function and also used to study its ability to function as an adjuvant. Gelam honey and tualang honey both have been studied to determine their effects on fertility. From these five honeys reviewed, the most studied honey is tualang honey that showed significant impact not only on general health being and wound healoing, but also on cancer, inflammation, infection, oxidative stress, cognitive function as well as potential adjuvant. The studies were carried out on different study model from cell lines (in vitro) animal such as Sprague-dawley rats and Wistar albino rats and also human. Conclusion:Honey is a natural compound with significant impact on health and general well-being. These effects might be due to its phenolics and flavonoid content as well as its involvement as signalling molecule that initiates the possible mechanism that needs to be further clarified in the future in treating and preventing diseases.

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“…Manuka honey also shows antioxidant property as it attenuates H 2 O 2 -induced oxidative stress in human whole blood cell (Zivkovic et al 2018). Tualang honey, apart from having anticancer, antiinflammatory, antioxidant and wound healing properties, it also possess antinociceptive property in human and rats (Abdullah et al 2015;Aziz et al 2014). It was reported to improve cognitive function and memory performance (Al-Rahbi et al 2014;Othman et al 2011).…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Properties of Stingless Bee Honey and Its Effect on the Viability of Lymphoblastoid Cell Line

Hazirah¹,

My²,

Karim³

2019

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Penyelidikan madu lebah (kelulut madu) merupakan bidang baru dalam penyelidikan perubatan. Walaupun ia telah digunakan sebagai makanan tradisional dan tambahan selama berabad-abad, pengetahuan mengenai potensi kesihatannya secara saintifik dan terutama pada sifat antioksidannya masih sedikit. Sifat-sifat antioksidan madu diukur dengan menggunakan asai potensi pengurangan ferio, dan mengukur jumlah kandungan fenol dan flavonoid menggunakan spektrofotometri UV. Kandungan jumlah fenolik, jumlah kandungan flavonoid dan potensi antioksidan penurunan ferum madu kelulut Malaysia yang dihasilkan oleh Trigona spp. didapati 844.45 mg RE/kg madu, 78.29 mg RE/kg madu dan 1132.66 mM FE/ kg madu masing-masing. Penemuan kami menunjukkan korelasi yang kuat antara jumlah fenolik dan kandungan flavanoid dengan potensi antioksidannya pada R 2 = 0.920 dan R 2 = 0.951. Kesan madu pada daya hidup sel selanjar limfoblastoid (LCL) juga diselidiki. Sel-sel dikulturkan dalam medium RPMI-1640 ditambah dengan 0-500 μg/mL madu kelulut selama 24 jam. Daya hidup sel yang diukur menggunakan ujian MTS menunjukkan bahawa suplemen madu meningkatkan daya hidup LCL sehingga 164.64% (p<0.01). Peningkatan ketara dalam daya hidup sel mungkin disebabkan oleh sifat antioksidan madu kelulut.

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The Antinociceptive Effects of Tualang Honey in Male Sprague-Dawley Rats: A Preliminary Study

Cited by 20 publications

References 28 publications

Preemptive Effects of Administration of Tualang Honey on Inflammatory Responses in Adult Male Rats

Preemptive Effects of Administration of Tualang Honey on Inflammatory Responses in Adult Male Rats

Honey as Versatile Remedy: A Focus on Selected Honeys

Antioxidant Properties of Stingless Bee Honey and Its Effect on the Viability of Lymphoblastoid Cell Line

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